The Effect of Puguntano (Curanga Fel-Terrae [Lour.]) Extract on Adiponectin Receptor (Adipor) in Rats With Type 2 Diabetes Mellitus

Lindarto, Dharma; Machrina, Yetty; Syafril, Santi; Saragih, Awaluddin

doi:10.22159/ajpcr.2019.v12i2.30456

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…The effect of poguntano extract on diabetes mellitus has been studied previously. Lindarto et al ( 7 ) studied the effect of Poguntano on adiponectin receptors in diabetic rats. The result of the study shows that rats treated with Poguntano extract expressed higher Adiponectin receptors compared to control.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis

Widjaja¹,

Rusdiana²,

Wiyono³

2022

Med Arch

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Background: Poguntano (Picria fel-terrae Merr) is a traditional herb commonly used as a blood glucose lowering agent in Indonesia. However, the effectiveness of the herb has not yet been established. Objective: This systematic review and meta-analysis aim to review the hypoglycemic effect of Poguntano extract in lowering plasma glucose levels. Methods: We conducted a literature search using peer-reviewed databases for relevant articles on Poguntano extract in animal models of diabetes. The effect size was pooled using a random effect model. Results: Two animal studies were included in the systematic review and meta-analysis. There was a significant difference in plasma glucose levels between diabetic control and rats treated with Puguntano extract (MD: 28.77; 95%CI: 6.20–51.34; p=0.01). There was no significant difference between non-diabetic control and Poguntano extract. Conclusion: Poguntano extract lowers the blood glucose levels in diabetic rats compared to control.

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Section: Discussionmentioning

confidence: 99%

Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis

Widjaja¹,

Rusdiana²,

Wiyono³

2022

Med Arch

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“…Its secondary metabolites are thought to mediate its beneficial effects because tannins increase muscle glucose uptake by enhancing PI3K, activating p38 MAPK, and increasing GLUT-4 translocation [12]; flavonoids increase GLUT-4 translocation by activating the PI3K/Akt pathways [13]; triterpenoids increase the activation of IRS-1 [14]; and saponins increase GLUT-4 expression via the PI3K/Akt pathway [15]. A previous study has shown that puguntano improves glucose metabolism and ameliorates insulin resistance, alongside an increase in expression of adiponectin receptor (AdiporR) in diabetic rats [16]. Furthermore, another previous study has demonstrated that quercetin which contains a flavonoid compound, activates both the PI3K/Akt and MAPK pathways in skeletal muscle [17].…”

Section: Introductionmentioning

confidence: 99%

Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (Curanga Fel-Terrae [Merr.]) Leaf Extract

Syafril¹,

Lindarto²,

Lelo³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Defects in post-receptor insulin signalling are the major cause of insulin resistance in type 2 diabetes mellitus (T2DM). AIM: This study aimed to investigate the correlations between insulin receptor substrate (IRS)-1 with phosphoinositide 3-kinase (PI3K) and p38 mitogen-activated protein kinase (MAPK) levels after puguntano (Curanga fel-terrae [Merr.]) leaf extract treatment in a rat model of T2DM. METHODS: A combination of high-fat diet-feeding (HFD) and multiple low dose intraperitoneal injections of streptozotocin was used to induced T2DM in 48 Wistar rats, which were then randomly divided into control and treatment groups (n = 24 per group). Puguntano leaf extract was administered to the treatment group once daily (200 mg/kg.bw) for 10 days. IRS-1, PI3K and p38 MAPK levels were measured in skeletal muscle using sandwich ELISAs in control group after becoming T2DM and in the treatment group after 10 days of puguntano treatment. Data were analysed using the Wilcoxon test and Spearman’s correlation. RESULTS: IRS-1, PI3K and p38 MAPK levels were significantly higher in the treatment group than in the control group. There were also significant positive correlations between IRS-1 with PI3K and p38 MAPK levels (r = 0.375, p = 0.035; r = 0.552, p = 0.003; respectively) after the treatment. CONCLUSION: This study demonstrated significant positive correlations between IRS-1 with PI3K and p38 MAPK levels after puguntano leaf extract treatment of T2DM rats.

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Effect of Picriafel-terrae Merr. leaves extract on VEGF, Interleukin-6, Prostate Index, and Histopathology in Obesity Rats with Benign Prostate Hyperplasia

Saidi Nasution,

Lindarto,

Mirsya Warli

et al. 2024

RJPT

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Benign prostate hyperplasia (BPH) is a life-threatening condition that primarily affects geriatric patients, with obesity serving as a major risk factor. Several studies have also reported the role of obesity as a risk factor for other chronic non-communicable diseases, such as cardiovascular disease and type 2 diabetes. Therefore, this study aims to investigate the effect of Picriafel-terrae Merr (PF) leaf extract on rat-induced obesity and BPH. The sample population comprised male Wistar rats, which were randomly divided into 5 different groups. Group 1 (G1) served as the normal, Group 2 (G2) was the negative control consisting of obese rats with BPH and treated with PF extract, while Group 3 (G3) was the positive control administered 1 mg/kg BW finasteride. In addition, Groups 4 (G4) and 5 (G5) were administered PF extract at varying doses of 100 mg/kg BW and 200 mg/kg BW, respectively. During the experiment, the test rats received subcutaneous injections of 10 mg/kg BW testosterone for 4 weeks, followed by a high-fat diet for 12 weeks and oral administration of PF extract for 10 days. The prostate index was then calculated and examined histopathologically, followed by ELISA for the detection of interleukin-6 and Vascular Endothelial Growth Factor (VEGF). The results showed a statistically significant increase in interleukin-6 levels (p=0.024), prostate index scores (p<0.001), and histopathological examination of the prostate epithelial and stromal cells (p<0.001). However, VEGF levels were not affected by the administration of PF extract (p=0.274). Based on these results, PF extract could reduce the prostate index markers and prostate histopathology in obese Wistar rats with BPH.

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The Effect of Puguntano (Curanga Fel-Terrae [Lour.]) Extract on Adiponectin Receptor (Adipor) in Rats With Type 2 Diabetes Mellitus

Cited by 3 publications

References 20 publications

Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis

Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis

Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (Curanga Fel-Terrae [Merr.]) Leaf Extract

Effect of Picriafel-terrae Merr. leaves extract on VEGF, Interleukin-6, Prostate Index, and Histopathology in Obesity Rats with Benign Prostate Hyperplasia

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