The effect of pulsed xenon ultraviolet light disinfection on healthcare-associated Clostridioides difficile rates in a tertiary care hospital

Attia, Fibi; Whitener, Cynthia; Mincemoyer, Scott; Houck, Justin; Julian, Kathleen G.

doi:10.1016/j.ajic.2019.12.019

Cited by 17 publications

(19 citation statements)

References 7 publications

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“…Four studies were excluded as, two did not utilise PX-UVL systems [23,24], one reported overlapping data [25] with an included study [26] and the other assessed the combination of screening, hand hygiene education and PX-UVL on HAI rates [27]. A total of 11 studies were included in the systematic review [18,19,26,[28][29][30][31][32][33][34][35].…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

“…PX-UVL was utilised after baseline cleaning in all studies; the majority used 5-min cycles of PX-UVL for disinfection of hospital rooms and the number of cycles varied from 2 to 4. Except for three studies [19, 31, 35], all trials reported a significant reduction in HAI rates after the use of PX-UVL in their establishment.…”

Section: Resultsmentioning

confidence: 99%

“…A total of seven studies reported data on CDI rates [18,19,26,[29][30][31]34]. Pooled analysis indicated a significant reduction of CDI rates with the use of PX-UVL (IRR: 0.73, 95% CI 0.57-0.94, I 2 = 72%, P = 0.01) ( Fig.…”

Section: Discussionmentioning

confidence: 99%

“…The disinfection efficacy of PX-UVL is dramatically reduced as the distance from the device increases [14] and high-touch surfaces need to be brought closer to the apparatus for optimal disinfection. There is also a potential negative impact of shadows, room size and configuration on the disinfection efficiency [19].…”

Section: Discussionmentioning

confidence: 99%

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Role of pulsed-xenon ultraviolet light in reducing healthcare-associated infections: a systematic review and meta-analysis

et al. 2020

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Pulsed-xenon-ultraviolet light (PX-UVL) is increasingly used as a supplemental disinfection method in healthcare settings. We undertook a systematic search of the literature through several databases and conducted a meta-analysis to evaluate the efficacy of PX-UVL in reducing healthcare-associated infections. Eleven studies were included in the systematic review and nine in the meta-analysis. Pooled analysis of seven studies with before-after data indicated a statistically significant reduction of Clostridium difficile infection (CDI) rates with the use of the PX-UVL (incidence rate ratio (IRR): 0.73, 95% CI 0.57–0.94, I2 = 72%, P = 0.01), and four studies reported a reduction of risk of methicillin-resistant Staphylococcus aureus (MRSA) infections (IRR: 0.79, 95% CI 0.64–0.98, I2 = 35%, P = 0.03). However, a further four trials found no significant reduction in vancomycin-resistant enterococci (VRE) infection rates (IRR: 0.80, 95% CI 0.63–1.01, I2 = 60%, P = 0.06). The results for CDI and MRSA proved unstable on sensitivity analysis. Meta-regression analysis did not demonstrate any influence of study duration or intervention duration on CDI rates. We conclude that the use of PX-UVL, in addition to standard disinfection protocols, may help to reduce the incidence of CDI and MRSA but not VRE infection rates. However, the quality of evidence is not high, with unstable results and wide confidence intervals, and further high-quality studies are required to supplement the current evidence.

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Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Role of pulsed-xenon ultraviolet light in reducing healthcare-associated infections: a systematic review and meta-analysis

et al. 2020

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“…These studies have been carried out mainly against bacteria, which hints about its potential effectivity against viruses. The efficacy of PL, alone or as a complement of standard cleaning with disinfectants, has been proved on personal protective equipment [ 67 ], respirators [ 67 ], touching surfaces of hospital units (surgical sites, isolation units, hematology and bone marrow transplant units) [ [69] , [70] , [71] , [72] ], hospital rooms [ 69 , [73] , [74] , [75] , [76] , [77] , [78] , [79] ], postdischarge patient isolation rooms [ 80 ] clinical laboratories [ 81 ], human milk feed preparation areas [ 82 ], operating rooms [ 83 ], intensive care units [ 80 ] and burn units [ 84 ]. Table 2 gives an overview of these studies which compiles results of case studies of heterogeneous nature where a PL system was used to disinfect a room.…”

Section: Use In Health Care Facilitiesmentioning

confidence: 99%

Potential of pulsed light technology for control of SARS-CoV-2 in hospital environments

Jean

Rodríguez-López

Jubinville

et al. 2021

Journal of Photochemistry and Photobiology B: Biology

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The emergence of the SARS-CoV-2 infection and its potential transmission through touching surfaces in clinical environments have impelled the use of conventional and novel methods of disinfection to prevent its spreading. Among the latter, pulsed light may be an effective, non-chemical decontamination alternative. Pulsed light technology inactivates microorganisms and viruses by using high intensity polychromatic light pulses, which degrades nucleic acids and proteins. This review describes this technology, compiles and critically analyzes the evidence about the virucidal efficacy of pulsed light technology with view on its potential use against SARS-CoV-2 in touching surfaces in health-care facilities. The efficacy of pulsed light proved against many different kind of viruses allows to conclude that is a suitable candidate to inactivate SARS-CoV-2 as long as the required fluence is applied and the appropriated exposure to contaminated surfaces is guaranteed.

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Impact of no-touch ultraviolet light room disinfection systems on Clostridioides difficile infections

McMullen¹,

Guth

Wood

et al. 2021

American Journal of Infection Control

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The effect of pulsed xenon ultraviolet light disinfection on healthcare-associated Clostridioides difficile rates in a tertiary care hospital

Cited by 17 publications

References 7 publications

Role of pulsed-xenon ultraviolet light in reducing healthcare-associated infections: a systematic review and meta-analysis

Role of pulsed-xenon ultraviolet light in reducing healthcare-associated infections: a systematic review and meta-analysis

Potential of pulsed light technology for control of SARS-CoV-2 in hospital environments

Impact of no-touch ultraviolet light room disinfection systems on Clostridioides difficile infections

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