The effect of quercetin supplementation on the components of metabolic syndrome in adults: A systematic review and dose–response meta-analysis of randomized controlled trials

Quercetin: Exploring Its Unique Flavonol Properties, Bioavailability, Safety Profile, and Therapeutic Potential in High-Impact Medical Conditions

“…Reduces systolic blood pressure significantly but has no effect on other cardiovascular risk factors and inflammatory markers in humans [35] • Protects against atherosclerosis by interfering with multiple pathways [13] • Improves endothelial function and reduces oxidative stress, inflammation, and apoptosis [34] Metabolic Syndrome Quercetin can maintain metabolism and treat metabolic syndrome, including obesity, insulin resistance, hypertension, and dyslipidemia. These conditions are risk factors for type 2 diabetes, CVD, and stroke [14,36]. The specific effects are highlighted as follows:…”

“…• Improves metabolic syndrome by regulating insulin secretion, enhancing glucose uptake by tissues, and improving glucose metabolism through modulating key enzymes and antioxidant and anti-inflammatory properties [36,37] • Protects against oxidative stress and chronic inflammation and enhances adiponectin levels, regulating lipid and glucose metabolism [38] • Ameliorates dyslipidemia by reducing oxidative stress, lowering blood pressure, and improving systolic blood pressure and insulin levels [14] • Improves various metabolic abnormalities related to metabolic syndrome, such as dyslipidemia, adiposity, and glucose intolerance [39] • Improves insulin sensitivity and secretion and reduces blood glucose levels in diabetic animal models [39] Neurodegenerative Disorders Quercetin has therapeutic applications in neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, due to its antioxidant, anti-inflammatory, and neuroprotective effects [12]. The specific effects are highlighted as follows:…”

“…However, excessive supplementation of quercetin may lead to side effects such as headache, tingling, and heart palpitations, particularly when administered intravenously [13]. Nevertheless, such side effects are rare, and generally, quercetin is considered safe when supplemented through food and drinks [14]. Associated with enhanced exercise performance Inflammation, blood pressure, and blood sugar Quercetin has been linked to reduced inflammation, blood pressure, and blood sugar levels in human studies…”