The Effect of Quetiapine and Olanzapine on Thyroid Function in Schizophrenic Patients

Samawi, Ola H; Al-dabbas, Rawan Mahmoud; Bisharat, Toleen I; Aldowaib, Bayan A; AlAdayleh, Farah A

doi:10.36347/sajp.2020.v09i05.003

Cited by 2 publications

(3 citation statements)

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“…There were twenty observational or experimental studies (Table 2) that included a total of 6880 patients who were treated with quetiapine. 2,4,9,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] The number of participants on quetiapine was not reported in one study. 41 Of these patients, the majority were women in the age group 18 to 65 years of age.…”

Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

“…25 Thirteen observational or experimental studies showed a decrease in thyroxine levels. 2,4,[27][28][29][30][31][32][33][34][35]37,41,42 Among these, TSH level was increased, compared to baseline, in 6 studies. 4,31,34,35,39,42 Three studies that only measured TSH showed no difference in TSH levels.…”

Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

“…2,4,[27][28][29][30][31][32][33][34][35]37,41,42 Among these, TSH level was increased, compared to baseline, in 6 studies. 4,31,34,35,39,42 Three studies that only measured TSH showed no difference in TSH levels. 26,32,38 Hypothyroidism was reported in 6.5% of patients on combination therapy (lithium or divalproex) and in 2.4% of patients on monotherapy, respectively.…”

Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

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Quetiapine‐Induced Thyroid Dysfunction: A Systematic Review

Khoodoruth

Abdo

Ouanes

2021

The Journal of Clinical Pharma

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Thyroid abnormalities are documented consequences of quetiapine treatment. This may have clinical implications as changes in thyroid hormones may deteriorate a person's affective state. Yet less is known about the clinical factors and underlying mechanisms associated with thyroid hormones on quetiapine therapy. We therefore systematically reviewed the published literature of evidence of quetiapine-induced thyroid abnormalities. We searched MEDLINE, PsycINFO, Google Scholar, and EMBASE for articles in which individuals developed biochemically confirmed thyroid abnormalities (with or without clinical symptoms) while on quetiapine treatment. We included case reports, case series, observational, and experimental studies. We included 32 studies, 20 of which were observational and experimental studies. There were 10 case reports and 1 case series. All the research designs suggested an association between quetiapine and hypothyroidism. However, these findings were limited by the quality of the included studies and the general lack of either a clear temporal relationship or dose response. Quetiapine has been associated with thyroid abnormalities, mainly with hypothyroidism. Drug imputability in these abnormalities is not always clear, and the underlying pathophysiology may include immunological and nonimmunological mechanisms. Large prospective studies are required to clarify this association and to further inform the management of patients treated with quetiapine where hypothyroidism occurs.

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Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

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Quetiapine‐Induced Thyroid Dysfunction: A Systematic Review

Khoodoruth

Abdo

Ouanes

2021

The Journal of Clinical Pharma

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Thyroid dysfunction in early psychosis: improving quality of care

Ansari,

Kelbrick,

Jaleel

et al. 2024

Prescriber

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People in EIP services are frequently prescribed antipsychotic medication, and often in combination with other psychotropics, all with increased risk of thyroid dysfunction. Undiagnosed and diagnosed thyroid dysfunction can have potential significant implications on both clinical outcomes and treatment for patients with early psychosis. Here, the authors present a clinical practice guideline for the management of thyroid dysfunction in EIP.

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The Effect of Quetiapine and Olanzapine on Thyroid Function in Schizophrenic Patients

Cited by 2 publications

References 0 publications

Quetiapine‐Induced Thyroid Dysfunction: A Systematic Review

Quetiapine‐Induced Thyroid Dysfunction: A Systematic Review

Thyroid dysfunction in early psychosis: improving quality of care

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