The Effect of Rabeprazole on LES Tone in Experimental Rat Model

Duman, Mustafa; Polat, Erdal; Ozer, Mahmut; Demırcı, Yeliz; Yaşar, Necdet Fatih; Akyüz, Cebrail; Uzun, Orhan; Peker, Kıvanç Derya; Genç, Ece; Yol, Sinan

doi:10.3109/08941939.2012.733487

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…Relexant or inhibitory effects of PPIs at high doses were demonstrated on vascular precontracted smooth muscle, gallbladder, prostate, corpus cavernosum, myometrium, and lower esophageal sphincter. [1][2][3][4][5][6][7] Therefore, in our study, we conducted the experiment from concentration of 10 −6 M, which is actually about the Cmax of rabeprazole after single oral dosage of 20 mg, to 10 −3 M. 23 The pathophysiological mechanism of these effects has yet to be identified but the most popular proposed model is the inhibition of voltage operated Ca 2＋ channels. In this study, we planned to observe the dose dependent effects of rabeprazole on the pylorus tone in the isolated human pylorus preparations, independent from any stimulation by acidity, paracrine hormones, and vagus nerve.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Two other studies, conducted after these previous studies, have shown that PPIs may also induce smooth muscle relaxation in lower esophageal sphincter in rat models. 6,7 The effects of PPIs, which are commonly used in treatment of gastritis, gastric ulcer, and gastroesophageal reflux disease on pylorus, have yet to be investigated. Pylorus is the most important control mechanism of the flow between the stomach and the intestines.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Effects of Rabeprazole on Human Pylorus Tone

Yaşar

Polat

Duman

et al. 2015

J Neurogastroenterol Motil

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Background/Aims It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle. Methods Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and response to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled water was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10 −6 , 10 −5 , 10 −4 , and 10 −3 M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured. Results The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth intervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval. Even though muscles tones were not different in both groups during all intervals, it was remarkable that the muscle tone was significantly decreased in the rabeprazole group during the fourth interval compared to the first and second intervals. Conclusions In the present study, high doses of rabeprazole reduced contraction frequencies, maximum contraction values, and muscle tone of human pylorus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro Effects of Rabeprazole on Human Pylorus Tone

Yaşar

Polat

Duman

et al. 2015

J Neurogastroenterol Motil

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“…GERD conventional therapy involves the use of anti-secretory drugs such as proton pump inhibitors (PPI) and H2 receptor antagonists (HsRA) [16,17]. Despite of PPI efficacy to treat GERD, there is still a substantial group of cases (≈40% in some studies) who do not experience symptom relief with a standard PPI dose, due to transient lower esophageal sphincter relaxations, sensitivity to weakly acidic and/ or alkaline reflux, large volume of reflux and/or esophageal hypersensitivity [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Combined Therapy Effect of D-002 and Omeprazole on Chronic Esophagitis Induced by Duodenal Reflux in Rats

Zamora¹,

Mena²,

Molina³

et al. 2018

Journal of Gastroenterology and Metabolism

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Gastroesophageal reflux disease is a common gastrointestinal disorder. D-002 (beeswax alcohols) and omeprazole (OMP) present protective effects on esophagitis by reflux. In this study, the effect of combined therapy D002 + OMP on duodenum-esophageal reflux (DER) induced-esophagitis in rats was evaluated. Rats were randomized into five groups: one negative control and fourth groups with DER, including a positive control, two with D-002 and OMP (200 and 20 mg/kg, respectively), and other with combination therapy D-002 + OMP (200 + 20 mg/kg, respectively). All treatments were orally administered for 14 days after DER. Esophageal lesions' index (ELI), Histological score (HS) and malondialdehyde (MDA) content in esophagus were determined. Positive controls exhibited increase ELI, HS and MDA in esophagus compared to negative controls. The combination therapy lowered significantly both ELI (48.05%) and MDA (67.8%) compared to positive controls, but without significant differences compared to their respective monotherapies. However, the combination therapy significantly reduced the HS respect to the positive control, reaching 96% inhibition, an effect that was higher than each of the monotherapies. In conclusion, the administration of the combination therapy (D-002 + OMP) represents an additional benefit in the protection of esophageal tissue with respect to treatment with monotherapies.

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The Effect of Rabeprazole on LES Tone in Experimental Rat Model

Abstract: In the present study, rabeprazole caused no direct significant change in LES tone in the therapeutic dose range applied to the organ bath. However, rabeprazole at the high dose caused a significant decrease in the LES tone.

Cited by 2 publications

References 39 publications

In Vitro Effects of Rabeprazole on Human Pylorus Tone

In Vitro Effects of Rabeprazole on Human Pylorus Tone

Combined Therapy Effect of D-002 and Omeprazole on Chronic Esophagitis Induced by Duodenal Reflux in Rats

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