The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2

Wang, Jianxin; Yan, Yonggang; Si, Honglin; Li, Jianyu; Zhao, Yanjie; Gao, Tianlin; Pi, Jingbo; Zhang, Rong; Chen, Rui; Chen, Wen; Zheng, Yuxin; Jiang, Menghui

doi:10.1016/j.ecoenv.2023.114702

Cited by 11 publications

(5 citation statements)

References 79 publications

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“…Moreover, PM2.5 can also exert additional negative effects on animal growth performance. These effects included a significant increase in inflammatory microorganisms within the animal's gastrointestinal tract ( Wang et al, 2023 ), heightened energy expenditure due to stress ( Eid et al, 2003 ; Malheiros et al, 2003 ), and impaired cognitive function resulting from neural damage ( Allen et al, 2014 ). Collectively, these impacts not only reduced feed intake but also hindered feed utilization efficiency.…”

Section: Discussionmentioning

confidence: 99%

Serum metabolome responses induced by long-term inoculation of suspended PM2.5 in chicken

Chen,

Bai,

Lou

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Serum metabolome responses induced by long-term inoculation of suspended PM2.5 in chicken

Chen,

Bai,

Lou

et al. 2024

Poultry Science

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“…Animal studies reveal that environmental pollutants notably disrupt the composition of the gut microbiota ( 96 – 98 ). Microbes ingested with PM 2.5 induce inflammatory responses in local immune cells, increase intestinal permeability, and alter the gut environment, promoting the growth of specific microbial strains adapted to an inflammatory milieu ( 99 ).…”

Section: Pm 25 Exposure and Gut Microbiota Dynamic...mentioning

confidence: 99%

Air pollution accelerates the development of obesity and Alzheimer’s disease: the role of leptin and inflammation - a mini-review

Campolim,

Schimenes,

Veras

et al. 2024

Front. Immunol.

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Air pollution is an urgent concern linked to numerous health problems in low- and middle-income countries, where 92% of air pollution-related deaths occur. Particulate matter 2.5 (PM2.5) is the most harmful component of air pollutants, increasing inflammation and changing gut microbiota, favoring obesity, type 2 diabetes, and Alzheimer’s Disease (AD). PM2.5 contains lipopolysaccharides (LPS), which can activate the Toll-like receptor 4 (TLR4) signaling pathway. This pathway can lead to the release of pro-inflammatory markers, including interleukins, and suppressor of cytokine signaling-3 (SOCS3), which inhibits leptin action, a hormone that keeps the energy homeostasis. Leptin plays a role in preventing amyloid plaque deposition and hyperphosphorylation of tau-protein (p-tau), mechanisms involved in the neurodegeneration in AD. Approximately 50 million people worldwide are affected by dementia, with a significant proportion living in low—and middle-income countries. This number is expected to triple by 2050. This mini-review focuses on the potential impact of PM2.5 exposure on the TLR4 signaling pathway, its contribution to leptin resistance, and dysbiosis that exacerbates the link between obesity and AD.

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“…Coal can produce atmospheric pollutants such as smoke, sulfur dioxide, nitrogen oxides, and mercury compounds during combustion [4,5], of which PM 2.5 is an important factor in environmental problems such as low atmospheric visibility and haze weather. More research shows that air pollution caused by high concentrations of PM 2.5 is an important factor in inducing chronic respiratory and circulatory diseases [6][7][8][9]. Therefore, it is necessary to improve the fine particle removal efficiency of dust collectors to achieve the goal of controlling PM 2.5 emissions and reducing pollution.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Humidification and Chemical Agglomeration to Improve Capturing the Fine Particulate Matter by Electrostatic Precipitator

Chen,

Li,

Wang

et al. 2024

Coatings

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The wet electrostatic precipitator (WESP) overcomes the shortcomings of traditional electrostatic precipitators, such as dust re-entrainment and back corona. It can effectively remove high-specific-resistivity dust, with a good removal effect on PM2.5. It is proposed to adopt chemical agglomeration and humidification agglomeration technology in the wet electrostatic precipitators to achieve ultra-low dust emissions from coal-fired power plants. The results show that the addition of chemical agglomerates, surfactants, and water vapor all affect the dust diameter of coal-fired power plants. After adding sesbania gum (SG), the D50 of dust particles increases from 28.29 μm to 48.22 μm. And the D50 of dust particles is 36.46 μm when spraying 3.6 kg/h water vapor only. With the cooperation of chemical agglomeration agents and water vapor, the dust agglomeration effect and removal efficiency can be further improved. When 10 mg/L SG is synergistically combined with 2.9 kg/h water vapor, the D50 is 64.75 μm, and the dust removal efficiency reaches 97.88%. On this basis, by adding 5 mg/L of Hexadecyltrimethylammonium bromide (CTAB), the D50 is 83.06 μm, and the dust removal efficiency increases to 98.62%. The synergistic effect of chemical agglomeration and humidification agglomeration promotes the aggregation of dust from coal-fired power plants. It can improve the removal efficiency of WESP for fine particulate matter but has little impact on the operation of existing equipment. The synergistic effects of multiple agglomeration technologies are also the direction for future research on the removal efficiency of fine particulate matter.

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The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2

Cited by 11 publications

References 79 publications

Serum metabolome responses induced by long-term inoculation of suspended PM2.5 in chicken

Serum metabolome responses induced by long-term inoculation of suspended PM2.5 in chicken

Air pollution accelerates the development of obesity and Alzheimer’s disease: the role of leptin and inflammation - a mini-review

Synergistic Humidification and Chemical Agglomeration to Improve Capturing the Fine Particulate Matter by Electrostatic Precipitator

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