The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women

Lipovac, Markus; Chedraui, Peter; Gruenhut, Christine; Gocan, Anca; Kurz, Christine; Neuber, Benedikt; Imhof, Martin

doi:10.3109/09513590.2011.593671

Cited by 43 publications

(42 citation statements)

References 34 publications

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“…In accordance with the calculation it was necessary for 50 participants to complete the study. Minimal clinically important difference in hot flush frequency was found to be a difference of at least 15% as determined from data published by Lipovac et al (2012)[18]. …”

Section: Methodsmentioning

confidence: 81%

“…Bioactive isoflavones from Red Clover (RC) (particularly Biochanin A and Formononetin) show promise as candidates for treatment of menopause symptoms as recent clinical trials have demonstrated beneficial effects against menopausal VMS and show minimal side effects with treatment [18–20]. Moreover, the safety profile of these compounds is promising and tested in numerous human trials.…”

Section: Introductionmentioning

confidence: 99%

“…Equivalent monitor sensitivity and performance sampling at the sternum and forearm has previously been demonstrated [34]. The use of skin conductance (SC)s in RCTs remains scarce due to the relative infancy of the methodology [18,35]. …”

Section: Introductionmentioning

confidence: 99%

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Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms

et al. 2017

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BackgroundNatural estrogen decline leads to vasomotor symptoms (VMS). Hormone therapy alleviates symptoms but increases cancer risk. Effective treatments against VMS with minimal cancer risks are needed. We investigate the effects of a highly bioavailable aglycone rich Red Clover isoflavone treatment to alleviate existing menopausal VMS, assessed for the first time by 24hour ambulatory skin conductance (SC)Methods and resultsWe conducted a parallel, double blind, randomised control trial of 62 peri-menopausal women aged 40–65, reporting ≥ 5 hot flushes/day and follicle stimulating hormone ≥35 IU/L. Participants received either twice daily treatment with bioavailable RC extract (RCE), providing 34 mg/d isoflavones and probiotics, or masked placebo formulation for 12 weeks. The primary outcome was change in daily hot flush frequency (HFF) from baseline to 12 weeks using 24hr SC. Secondary outcomes were change in SC determined hot flush intensity (HFI), self-reported HFF (rHFF) and hot flush severity (rHFS), blood pressure and plasma lipids. A significant decrease in 24hr HFF (P < 0.01) and HFI (P<0.05) was found when comparing change from baseline to 12 months of the RCE (-4.3 HF/24hr, CI -6.8 to -2.3; -12956 μS s-1, CI -20175 to -5737) with placebo (0.79 HF/24hr, CI -1.56 to 3.15; 515 μS s-1, CI -5465 to 6496). rHFF was also significantly reduced (P <0.05)in the RCE (-2.97 HFs/d, CI -4.77 to -1.17) group compared to placebo (0.036 HFs/d, CI -2.42 to 2.49). Other parameters were non-significant. RCE was well tolerated.ConclusionResults suggest that moderate doses of RCE were more effective and superior to placebo in reducing physiological and self-reported VMS. Findings support that objective physiological symptom assessment methods should be used together with self-report measures in future studies on menopausal VMS.Trial registrationClinicalTrials.gov NCT02028702

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Section: Methodsmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms

et al. 2017

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“…Although some efficacy of red clover extracts in the preventing of vasomotor symptoms was demonstrated in a meta-analysis of 5 clinical trials [5], more recently both lack of effects [6, 7] and favorable effects [8] were reported. The data on the long-term effects on the cardiovascular, breast, endometrial, and urogenital health, as well as bone health, are much scarcer [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Extracts fromTrifolium mediumL. andTrifolium pratenseL. on Development of Estrogen Deficiency-Induced Osteoporosis in Rats

Cegieła

Folwarczna

Pytlik

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Some plant species belonging to Trifolium L. genus are a source of isoflavones considered to exert phytoestrogenic activities. The aim of the present study was to examine the effects of standardized extract obtained from aerial parts of Trifolium medium L., in comparison with the extract of Trifolium pratense L., on the development of estrogen deficiency-induced osteoporosis in rats. Both Trifolium extracts, at doses corresponding to 10 and 20 mg/kg of isoflavone aglycones daily, or estradiol (0.2 mg/kg daily), were administered orally to ovariectomized (OVX) rats for 4 weeks. Serum bone turnover markers, bone mass, mineralization, and mechanical properties were studied. In OVX control rats, mechanical properties of the tibial metaphysis and femoral neck were strongly worsened in comparison with sham-operated control rats, and those of femoral diaphysis were unaffected. Estradiol counteracted the worsening of the tibial strength and increases in bone turnover markers. Both extracts significantly increased the strength of the femoral diaphysis and calcium and phosphorus content in the bone mineral, but only T. pratense extract increased the strength of the tibial metaphysis. In conclusion, effects of both Trifolium extracts differed from those of estradiol. It is possible that other than isoflavone extract constituents contributed to their skeletal effects.

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“…This effect was equivalent to a 76.9 % reduction in the total Hospital Anxiety and Depression Scale (HADS) score (76 % for anxiety and 78.3 % for depression) and an 80.6 % reduction in the total Zung Self-Rating Depression Scale (SDS) score. They also found that red clover isofl avone supplementation was more effective than placebo in reducing daily vasomotor frequency and overall menopausal intensity in postmenopausal women (Lipovac et al 2012 ). Studies by del Giorno et al ( 2010 ) found that a 12-month treatment of women aged 45-65 years with menopausal symptoms, with a daily dose of 40 mg Trifolium pratense , did not yield a signifi cant improvement in menopausal symptoms and sexual satisfaction.…”

Section: Clinical Studiesmentioning

confidence: 99%

Trifolium pratense

Lim¹

2013

Edible Medicinal and Non-Medicinal Plants

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SynonymsTrifolium borysthenicum Gruner, Trifolium bracteatum Schousb., Trifolium lenkoranicum (Grossh.) Roskov, Trifolium pratense var. lenkoranicum Grossh., Trifolium ukrainicum Opperman FamilyFabaceae, also placed in Papilionaceae Common/English Names Beebread, Broad-Leaved Clover, Chilean Clover, Cow Clover, Cowgrass Clover, Early Blooming Clover, June Clover, King's Crown, Mammoth Clover, Mammoth Red Clover, Meadow Clover, Meadow Honeysuckle, Meadow Trefoil, Medium Red Clover, Multi-Cut Clover, Peavine Clover, Purple Clover, Red Clover, Sweet Clover, Sweet Kitty Clover, Wild Clover

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The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women

Abstract: Red clover isoflavone supplementation was more effective than placebo in reducing daily vasomotor frequency and overall menopausal intensity in postmenopausal women.

Cited by 43 publications

References 34 publications

Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms

Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms

Effects of Extracts fromTrifolium mediumL. andTrifolium pratenseL. on Development of Estrogen Deficiency-Induced Osteoporosis in Rats

Trifolium pratense

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