The effect of rehabilitation measures on the severity of endotoxicosis and its relationship with changes in hemorheology in acute poisoning

Abstract

Introduction. The use of multidimensional statistical analysis methods (factorial and cluster methods) to study the pathogenesis and sanogenesis of acute poisoning (AP) with psychopharmacological agents (pPPhA), neurotoxicants (pNT) and corrosive substances (pCS) did not allow us to judge the presence of a direct connection between the hemorhealogy system (HR). We received a positive answer to this question earlier with the help of pair correlation analysis (PCA). New data on the sanogenetic effect of the applied methods of rehabilitation treatment in terms of changes in the indicators of HR and endotoxicosis (ET) and the relationship between them are also interesting. The purpose of the work is to assess the initial state of the indicators of HR and ET and the effect on them of a combination of medicinal and non–medicinal products used as part of rehabilitation measures for AP. Material and methods. Paired correlation analysis of the block structure of the obtained correlation matrices was applied to 52 patients with severe pPPhA, pNT and pCS. This analysis established the relationship between two indicators – both before the start of rehabilitation measures (the use of ethylmethylhydroxypyridine succinate, laser hemotherapy, hyperbaric oxygenation and mesodiencephalic modulation in accordance with the type of AP), and after their completion, before the discharge of patients from the hospital. Results. Statistically significant correlations were established between the indicators of HR and ET both before the start of treatment (0.44–0.94, without sign) and after its completion (0.49–0.99, without sign), which allowed us to confirm at a higher level a direct link between the development of HR and ET disorders, as well as to draw a conclusion about the sanogenetic effect of rehabilitation treatment. Limitations. The study has no limitations for further use of this methodological approach. Conclusion. The obtained data can serve as a justification for the introduction into practice of the proposed methods of mathematical analysis of the results of treatment measures.