The effect of repeated rotarod training on motor skills and spatial learning ability in Lurcher mutant mice

Cendelín, Jan; Korelusová, I; Vožeh, F

doi:10.1016/j.bbr.2007.12.013

Cited by 47 publications

(29 citation statements)

References 34 publications

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“…Amelioration of motor skills in Lurcher mice reared in an enriched environment stimulating voluntary activity was earlier found by Caston et al [40]. Present findings also confirm our preliminary study which described positive effect of the training on motor functions in adult Lurcher mice [20]. In the present study, we evaluated relative change of latencies during repeated sessions of motor tests.…”

Section: Motor Functionssupporting

confidence: 93%

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The Effect of Cerebellar Transplantation and Enforced Physical Activity on Motor Skills and Spatial Learning in Adult Lurcher Mutant Mice

2008

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Lurcher mutant mice represent a model of olivocerebellar degeneration. They are used to investigate cerebellar functions, consequences of cerebellar degeneration and methods of therapy influencing them. The aim of the work was to assess the effect of foetal cerebellar graft transplantation, repeated enforced physical activity and the combination of both these types of treatment on motor skills, spontaneous motor activity and spatial learning ability in adult B6CBA Lurcher mice. Foetal cerebellar grafts were applied into the cerebellum of Lurchers in the form of solid tissue pieces. Enforced motor activity was realised through rotarod training. Motor functions were examined using bar, ladder and rotarod tests. Spatial learning was tested in the Morris water maze. Spontaneous motor activity in the open field was observed. The presence of the graft was examined histologically. Enforced physical activity led to moderate improvement of some motor skills and to a significant amelioration of spatial learning ability in Lurchers. The transplantation of cerebellar tissue did not influence motor functions significantly but led to an improvement of spatial learning ability. Mutual advancement of the effects of both types of treatment was not observed. Spontaneous motor activity was influenced neither by physical activity nor by the transplantation. Physical activity did not influence the graft survival and development. Because nerve sprouting and cell migration from the graft to the host cerebellum was poor, the functional effects of the graft should be explained with regard to its trophic influence rather than with any involvement of the grafted cells into neural circuitries.

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Section: Motor Functionssupporting

confidence: 93%

“…Our preliminary experiments showed slight improvement of spatial learning ability and motor skills after enforced motor activity in adult Lurcher mutant mice [20].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Cerebellar Transplantation and Enforced Physical Activity on Motor Skills and Spatial Learning in Adult Lurcher Mutant Mice

2008

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“…Our studies showed that insulin and curcumin treatment normalized the increased blood glucose level of diabetic rats to near control. Rotarod test was performed to examine the motor incoordination (Cendelin et al 2008). The Rotarod experiment demonstrated the impairment of the motor function and coordination in the diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats

et al. 2009

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“…Lurcher mutants carry a spontaneous mutation in a gene coding for the GluR␦2 receptor, constituting a good model of cerebellar decortication, because adult individuals have no Purkinje cells (Caddy and Biscoe 1979;Cendelín et al 2008Cendelín et al , 2009Porras-García et al 2005;Vogel et al 2007;Yuzaki 2004;Zuo et al 1997). In the present study, we carried out the classical conditioning of eyelid responses with a delay paradigm in interpositus-lesioned and -nonlesioned wild-type and Lurcher mice.…”

Section: Introductionmentioning

confidence: 99%

Behavioral Characteristics, Associative Learning Capabilities, and Dynamic Association Mapping in an Animal Model of Cerebellar Degeneration

Porras-García

Sánchez-Campusano

Martı́nez-Vargas

et al. 2010

Journal of Neurophysiology

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Porras-García E, Sánchez-Campusano R, Martínez-Vargas D, Domínguez-del-Toro E, Cendelín J, Vožeh F, Delgado-García JM. Behavioral characteristics, associative learning capabilities, and dynamic association mapping in an animal model of cerebellar degeneration. J Neurophysiol 104: 346 -365, 2010. First published April 21, 2010 doi:10.1152/jn.00180.2010. Young adult heterozygous Lurcher mice constitute an excellent model for studying the role of the cerebellar cortex in motor performance-including the acquisition of new motor abilities-because of the early postnatal degeneration of almost all of their Purkinje and granular cells. Wild-type and Lurcher mice were classically conditioned for eyelid responses using a delay paradigm with or without an electrolytic lesion in the interpositus nucleus. Although the late component of electrically evoked blink reflexes was smaller in amplitude and had a longer latency in Lurcher mice than that in controls, the two groups of animals presented similar acquisition curves for eyeblink conditioning. The lesion of the interpositus nucleus affected both groups of animals equally for the generation of reflex and conditioned eyelid responses. Furthermore, we recorded the multiunitary activity at the red and interpositus nuclei during the same type of associative learning. In both nuclei, the neural firing activity lagged the beginning of the conditioned response (determined by orbicularis oculi muscle response). Although red nucleus neurons and muscle activities presented a clear functional coupling (strong correlation and low asymmetry) across conditioning, the coupling between interpositus neurons and either red nucleus neurons or muscle activities was slightly significant (weak correlation and high asymmetry). Lurcher mice presented a nonlinear coupling (high asymmetry) between red nucleus neurons and muscle activities, with an evident compensatory adjustment in the correlation of firing between interpositus and red nuclei neurons (a coupling with low asymmetry), aimed probably at compensating the absence of cerebellar cortical neurons.

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The effect of repeated rotarod training on motor skills and spatial learning ability in Lurcher mutant mice

Cited by 47 publications

References 34 publications

The Effect of Cerebellar Transplantation and Enforced Physical Activity on Motor Skills and Spatial Learning in Adult Lurcher Mutant Mice

The Effect of Cerebellar Transplantation and Enforced Physical Activity on Motor Skills and Spatial Learning in Adult Lurcher Mutant Mice

Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats

Behavioral Characteristics, Associative Learning Capabilities, and Dynamic Association Mapping in an Animal Model of Cerebellar Degeneration

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