The Effect of Reperfusion on Cerebral Activity in Donors after Circulatory Death Following Normothermic Regional Perfusion

Dalsgaard, Frederik F; Moeslund, Niels; Pedersen, Mona Kyndi; Montvilas, E.Q.; Eiskjær, Hans

doi:10.1016/j.healun.2021.01.1808

Cited by 1 publication

(1 citation statement)

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“…Many authors advocate that the AAV should be vented to air to ensure no collateral flow [28,29]. In Current Opinions, we previously reviewed porcine studies that demonstrated no meaningful resumption of brain blood flow or function after clamping of AAV in porcine models [7,[30][31][32]. Recently in humans, 2 deceased donors undergoing taNRP had transcranial Doppler ultrasonography performed.…”

Section: Science Addressing Ethical Concernsmentioning

confidence: 99%

Thoraco-abdominal normothermic regional perfusion for thoracic transplantation in the United States: current state and future directions

Bommareddi,

Lima,

Shah

et al. 2024

Current Opinion in Organ Transplantation

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Purpose of review To provide an update regarding the state of thoracoabdominal normothermic regional perfusion (taNRP) when used for thoracic organ recovery Recent findings taNRP is growing in its utilization for thoracic organ recovery from donation after circulatory death donors, partly because of its cost effectiveness. taNRP has been shown to yield cardiac allograft recipient outcomes similar to those of brain-dead donors. Regarding the use of taNRP to recover donor lungs, United Network for Organ Sharing (UNOS) analysis shows that taNRP recovered lungs are noninferior, and taNRP has been used to consistently recover excellent lungs at high volume centers. Despite its growth, ethical debate regarding taNRP continues, though clinical data now supports the notion that there is no meaningful brain perfusion after clamping the aortic arch vessels. Summary taNRP is an excellent method for recovering both heart and lungs from donation after circulatory death donors and yields satisfactory recipient outcomes in a cost-effective manner. taNRP is now endorsed by the American Society of Transplant Surgeons, though ethical debate continues.

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