The effect of respiratory muscle endurance training in patients with myasthenia gravis

Raßler, Beate; Hallebach, G; Kalischewski, Petra; Baumann, I.; Schauer, J.; Spengler, Christina M.

doi:10.1016/j.nmd.2007.01.001

Cited by 48 publications

(44 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Characteristics of these patients are given in Table 1. Five of them had already participated in our first RMET study several years ago [26]. All participants had experienced respiratory symptoms or problems in the past due to their myasthenia and, for this reason, were motivated to perform the respiratory endurance training.…”

Section: Methodsmentioning

confidence: 99%

“…Phase 1 included a four-week training period; during phase 2, the training was continued for another three months. The protocol of phase 1 was the same as applied in the first study [26] but without a detraining period. In brief, all patients including those who had already participated in the previous study received a detailed explanation and demonstration of all testing and training details and then practiced the use of the training device at home for one week 10 min per day.…”

Section: Methodsmentioning

confidence: 99%

“…This type of respiratory muscle endurance training (RMET) has also been applied in MG patients in a previous study [26]. Four weeks of this normocapnic hyperpnea training in MG patients resulted in a more than twofold enhancement of respiratory muscle endurance as reflected by time to exhaustion ( T Lim ) and total ventilated volume ( V Lim ) in a respiratory endurance (RE) test.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-Term Respiratory Muscle Endurance Training in Patients with Myasthenia Gravis: First Results after Four Months of Training

Raßler

Marx

Hallebach

et al. 2011

Autoimmune Diseases

Self Cite

View full text Add to dashboard Cite

Myasthenia gravis (MG) is characterized by reduced muscle endurance and is often accompanied by respiratory complications. Improvement of respiratory function is therefore an important objective in MG therapy. A previous study demonstrated that respiratory muscle endurance training (RMET) over four weeks increased respiratory muscle endurance of MG patients to about 200% of baseline. The purpose of the present study was to establish an appropriate maintenance training and to test its effects over four months. Ten patients with mild to moderate MG participated in this study. During the first month, they performed five training sessions per week. For the following 3 months, training frequency was reduced to five sessions per two weeks. Myasthenia score, lung function, and respiratory endurance were determined prior to training, after the first month, and after 4 months. Myasthenia score improved from 0.71 ± 0.1 to 0.56 ± 0.1 (P = 0.007). Respiratory endurance time increased from 6.1 ± 0.8 to 20.3 ± 3.0 min (P < 0.001). In conclusion, this RMET maintenance program is feasible and is significantly beneficial for MG patients.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long-Term Respiratory Muscle Endurance Training in Patients with Myasthenia Gravis: First Results after Four Months of Training

Raßler

Marx

Hallebach

et al. 2011

Autoimmune Diseases

Self Cite

View full text Add to dashboard Cite

show abstract

“…This result indicates that RMET is feasible and can improve respiratory muscle endurance in obese patients as previously reported in healthy subjects and in other diseases. 19,23,26,31,32 Although obese patients are known to breath at a lower lung volume (that is, with reduced functional residual volume), increasing by RMET their respiratory muscle capacity and thus their ability to deal with the reduced respiratory system compliance might modify their distance and change in the respiratory muscle endurance test duration from before to after the hospitalization period (CON group: white symbols; RMET group: black symbols).…”

Section: Effect Of Rmet On Lung Function and Respiratory Muscle Perfomentioning

confidence: 99%

Respiratory muscle endurance training in obese patients

Villiot-Danger

Borel

et al. 2010

Int J Obes

View full text Add to dashboard Cite

Objective: Increased respiratory muscle work is associated with dyspnea and poor exercise tolerance in obese patients. We evaluated the effect of respiratory muscle endurance training (RMET) on respiratory muscle capacities, symptoms and exercise capacity in obese patients. Design: A total of 20 obese patients hospitalized for 26 ± 6 days to follow a low-calorie diet and a physical activity program were included in this case-control study. Of them, 10 patients performed RMET (30-min isocapnic hyperpnea at 60-80% maximum voluntary ventilation, 3-4 times per week during the whole hospitalization period: RMET group), while the other 10 patients performed no respiratory training (control (CON) group). RMET and CON groups were matched for body mass index (BMI) (45 ± 7 kg m À2 ) and age (42 ± 12 years). Lung function, respiratory muscle strength and endurance, 6-min walking distance, dyspnea (Medical Research Council scale) and quality of life (short-form health survey 36 questionnaire) were assessed before and after intervention. Results: Similar BMI reduction was observed after hospitalization in the RMET and CON groups (À2±1 kg m À2 , Po0.001). No significant change in lung function and respiratory muscle strength was observed except for vital capacity, which increased in the RMET group ( þ 0.20±0.26 l, P ¼ 0.039). Respiratory muscle endurance increased in the RMET group only ( þ 52±27%, Po0.001). Compared with the CON group, the RMET group had greater improvement in 6MWT ( þ 54 ± 35 versus þ 1 ± 7 m, P ¼ 0.007), dyspnea score (À2±1 versus À1±1 points, P ¼ 0.047) and quality of life (total score: þ 251±132 versus þ 84±152 points, P ¼ 0.018) after hospitalization. A significant correlation between the increase in respiratory muscle endurance and improvement in 6MWT distance was observed (r 2 ¼ 0.36, P ¼ 0.005). Conclusions: The present study indicates that RMET is feasible in obese patients and can induce significant improvement in dyspnea and exercise capacity. RMET may be a promising tool to improve functional capacity and adherence to physical activities in this population, but further studies are needed to confirm these results.

show abstract

“…RMST is not recommended for patients with perforated tympanic membranes, oro-facial weakness, established daytime hypercapnia or thoracic instability. Endurance training as part of RMT has not been investigated in patients with Pompe disease, but preliminary data on other NMD suggest beneficial effects [60,61]. …”

Section: Managementmentioning

confidence: 99%

Practical Recommendations for Diagnosis and Management of Respiratory Muscle Weakness in Late-Onset Pompe Disease

Boentert

Prigent

Várdi³

et al. 2016

IJMS

View full text Add to dashboard Cite

Pompe disease is an autosomal-recessive lysosomal storage disorder characterized by progressive myopathy with proximal muscle weakness, respiratory muscle dysfunction, and cardiomyopathy (in infants only). In patients with juvenile or adult disease onset, respiratory muscle weakness may decline more rapidly than overall neurological disability. Sleep-disordered breathing, daytime hypercapnia, and the need for nocturnal ventilation eventually evolve in most patients. Additionally, respiratory muscle weakness leads to decreased cough and impaired airway clearance, increasing the risk of acute respiratory illness. Progressive respiratory muscle weakness is a major cause of morbidity and mortality in late-onset Pompe disease even if enzyme replacement therapy has been established. Practical knowledge of how to detect, monitor and manage respiratory muscle involvement is crucial for optimal patient care. A multidisciplinary approach combining the expertise of neurologists, pulmonologists, and intensive care specialists is needed. Based on the authors’ own experience in over 200 patients, this article conveys expert recommendations for the diagnosis and management of respiratory muscle weakness and its sequelae in late-onset Pompe disease.

show abstract

The effect of respiratory muscle endurance training in patients with myasthenia gravis

Cited by 48 publications

References 28 publications

Long-Term Respiratory Muscle Endurance Training in Patients with Myasthenia Gravis: First Results after Four Months of Training

Long-Term Respiratory Muscle Endurance Training in Patients with Myasthenia Gravis: First Results after Four Months of Training

Respiratory muscle endurance training in obese patients

Practical Recommendations for Diagnosis and Management of Respiratory Muscle Weakness in Late-Onset Pompe Disease

Contact Info

Product

Resources

About