The Effect of Respiratory Viral Infections on Patients With Cystic Fibrosis

Viral Respiratory Tract Infections in Cystic Fibrosis

“…They achieved the highest detection rate of 46% amongst all existing literature concerning respiratory viruses in the CF population during reported episodes of respiratory illness. The results compare favourably with previous studies and this may be that earlier studies relied heavily on repeated serological testing, either alone (Petersen, Hoiby et al 1981) or in combination with viral isolation (Wang, Prober et al 1984;Ramsey, Gore et al 1989;Pribble, Black et al 1990;Armstrong, Grimwood et al 1998;Hiatt, Grace et al 1999). They also achieved a viral detection rate of 18.3% from routine nasal samples and this is comparable to the seroconversion rate of 12.3% as reported by Wang et al (Wang, Prober et al 1984).…”

“…Early studies looking at respiratory viruses in CF relied on repeated serological testing, either alone (Petersen, Hoiby et al 1981) or in combination with viral cultures for viral detection (Wang, Prober et al 1984;Ramsey, Gore et al 1989;Pribble, Black et al 1990;Armstrong, Grimwood et al 1998;Hiatt, Grace et al 1999). These methods are relatively insensitive and more recent studies have utilised PCR based methodologies (Smyth, Smyth et al 1995;Collinson, Nicholson et al 1996;Punch, Syrmis et al 2004;Olesen, Nielsen et al 2006;).…”

“…The viruses implicated in causing respiratory symptoms in CF include RSV, adenovirus, PIV (Types 1 to 4) , influenza A&B, rhinovirus (Ramsey, Gore et al 1989;Smyth, Smyth et al 1995;Collinson, Nicholson et al 1996;) and more recently metapneumovirus (Garcia, Hiatt et al 2007). RSV represents 9-58% of all reported viral infection in CF, with the highest incidence in young children (Armstrong, Grimwood et al 1998).…”

“…More recent studies suggest no difference in the frequency of either upper respiratory tract illness (URTI) episodes (Hiatt, Grace et al 1999) or proven respiratory viral infections (Ramsey, Gore et al 1989) between children with CF and healthy controls, but children with CF have significantly more episodes of lower airway symptoms than controls (Ramsey, Gore et al 1989;Hiatt, Grace et al 1999). Ramsey et al (Ramsey, Gore et al 1989) prospectively compared the incidence and effect of viral infections on pulmonary function and clinical scores in 15 schoolage patients with CF aged between 5 to 21 years and their healthy siblings.…”

“…Ramsey et al (Ramsey, Gore et al 1989) prospectively compared the incidence and effect of viral infections on pulmonary function and clinical scores in 15 schoolage patients with CF aged between 5 to 21 years and their healthy siblings. Over a two-year period, samples were taken at regular two monthly intervals and during acute respiratory illnesses (ARI) for pharyngeal culture and serology for respiratory viruses.…”