The effect of resveratrol on blood pressure in a rat model of preeclampsia

Moraloğlu, Özlem; Üstün, Yaprak Engin; Tonguç, Esra; Var, Turgut; Tapisiz, Omer Lutfi; Ergün, Hakan; Güvenç, Tolga; Gacar, Ayhan

doi:10.3109/14767058.2011.599081

Cited by 27 publications

(25 citation statements)

References 18 publications

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“…Due to its natural and safe origin, the use of RESV has been reported in complications during pregnancy (22), including gestational diabetes mellitus (23). Of particular interest to our current study, the anti-hypertension property of RESV has also been demonstrated in a number of studies employing both animal and clinical studies (13, 14, 15, 16, 17). Given its widely reported anti-hypertensive function, we therefore also employed RESV in the current clinical trial among pregnant women affected by PE, with the hypothesis that RESV could also exhibit benefits in relieving hypertension in pregnancy-induced PE.…”

Section: Discussionmentioning

confidence: 85%

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Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia

Ding

Kang

Fan

et al. 2017

Endocrine Connections

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ObjectivePreeclampsia (PE) is a complication affecting pregnant women worldwide, which usually manifests as severe maternal hypertension. Resveratrol (RESV), a naturally existing polyphenol, is known to exhibit beneficial effects in cardiovascular disease including hypertension. We evaluated the outcome of treatment combining oral nifedipine (NIFE) and RESV against PE.Design and methodsUsing a randomized group assignment, 400 PE patients were enrolled and received oral treatments of either NIFE + RESV or NIFE + placebo. Primary endpoints were defined as time to control blood pressure and time before a new hypertensive crisis. Secondary endpoints were defined as the number of doses needed to control blood pressure, maternal and neonatal adverse effects.ResultsCompared with the NIFE + placebo group, the time needed to control blood pressure was significantly reduced in NIFE + RESV group, while time before a new hypertensive crisis was greatly delayed in NIFE + RESV group. The number of treatment doses needed to control blood pressure was also categorically lower in NIFE + RESV group. No differences in maternal or neonatal adverse effects were observed between the two treatment groups.ConclusionOur data support the potential of RESV as a safe and effective adjuvant of oral NIFE to attenuate hypertensive symptoms among PE patients.

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Section: Discussionmentioning

confidence: 85%

“…For instance, in rat model of PE, RESV was reported to reduce blood pressure (13), as well as inhibit trophoblast apoptosis through oxidative stress (14). In a pregnant mouse model with reduced blood supply to the uterus, RESV increased uterine artery blood flow velocity and fetal weight (15).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia

Ding

Kang

Fan

et al. 2017

Endocrine Connections

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“…The following food groups and food extracts have high AMPKactivating capacity: resveratrol (red grape skin extract) [114][115][116][117][118], nootkatone (grapefruit extract) [119], ajoene (garlic extract) [120], BDIM (cruciferous vegetable extract) [19,121], and many others [122]. Medicines activate AMPK including Asa [16], Met [35], phenformin [123,124], rosiglitazone, and phenobarbital [125,126], and there may be others.…”

Section: Discussionmentioning

confidence: 99%

Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos

Bolnick

Abdulhasan

Kilburn

et al. 2016

J Assist Reprod Genet

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Purpose The purpose of the present study is to test whether metformin, aspirin, or diet supplement (DS) BioResponse-3, 3′-Diindolylmethane (BR-DIM) can induce AMP-activated protein kinase (AMPK)-dependent potency loss in cultured embryos and whether metformin (Met) + Aspirin (Asa) or BR-DIM causes an AMPK-dependent decrease in embryonic development. Methods The methods used were as follows: culture post-thaw mouse zygotes to the two-cell embryo stage and test effects after 1-h AMPK agonists' (e.g., Met, Asa, BR-DIM, control hyperosmotic stress) exposure on AMPK-dependent loss of Oct4 and/or Rex1 nuclear potency factors, confirm AMPK dependence by reversing potency loss in two-cell-stage embryos with AMPK inhibitor compound C (CC), test whether Met + Asa (i.e., co-added) or DS BR-DIM decreases development of two-cell to blastocyst stage in an AMPK-dependent (CCsensitive) manner, and evaluate the level of Rex1 and Oct4 nuclear fluorescence in two-cell-stage embryos and rate of two-cell-stage embryo development to blastocysts. Result(s) Met, Asa, BR-DIM, or hyperosmotic sorbitol stress induces rapid~50-85 % Rex1 and/or Oct4 protein loss in twocell embryos. This loss is~60-90 % reversible by co-culture with AMPK inhibitor CC. Embryo development from twocell to blastocyst stage is decreased in culture with either Met + Asa or BR-DIM, and this is either >90 or~60 % reversible with CC, respectively. Conclusion These experimental designs here showed that Met-, Asa-, BR-DIM-, or sorbitol stress-induced rapid potency loss in two-cell embryos is AMPK dependent as suggested by inhibition of Rex1 and/or Oct4 protein loss with an AMPK inhibitor. The DS BR-DIM or fertility drugs (e.g., Met + Asa)Capsule Drugs metformin and aspirin and diet supplement BR-DIM cause AMPK-dependent potency loss and decrease embryonic development from two-cell to blastocyst stage. Reprod Genet (2016) 33:1027-1039 DOI 10.1007 that are used to enhance maternal metabolism to support fertility can also chronically slow embryo growth and block development in an AMPK-dependent manner.

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“…13 Green tea supplements are also reported to reduce blood pressure in healthy humans, 14 insulin-resistant adults 15 and in subjects with pre-hypertension. 16 Resveratrol, a polyphenol found in grape skin, lowers arterial pressure in hypertensive 17,18 and obese rat models. 19 Quercetin, a flavonol found in onions and apples, can also alleviate hypertension in pressure-overloaded rats 20 and spontaneously hypertensive rats.…”

Section: Introductionmentioning

confidence: 99%

A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects

et al. 2015

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The effect of resveratrol on blood pressure in a rat model of preeclampsia

Abstract: The present study demonstrated that resveratrol did not decrease blood pressure, and did not result in a significant response in blood flows and placental pathology parameters.

Cited by 27 publications

References 18 publications

Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia

Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia

Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos

A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects

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