2013
DOI: 10.1016/j.biomaterials.2013.05.035
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The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes

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Cited by 121 publications
(214 citation statements)
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References 59 publications
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“…Activated microglia and macrophages release a plethora of pro-inflammatory/cytotoxic soluble factors that can damage healthy bystander cells and the surrounding tissue (53–57). Pro-inflammatory cytokines can have direct toxic effects on neurons and oligodendrocytes, while reactive oxygen species and chemokines are involved in opening the BBB and recruiting new macrophages to sites of injury and inflammation (58). Several recent studies have also provided further support for the predominant role of macrophage-released factors on the recording function and the neuroinflammatory response.…”
Section: Discussionmentioning
confidence: 99%
“…Activated microglia and macrophages release a plethora of pro-inflammatory/cytotoxic soluble factors that can damage healthy bystander cells and the surrounding tissue (53–57). Pro-inflammatory cytokines can have direct toxic effects on neurons and oligodendrocytes, while reactive oxygen species and chemokines are involved in opening the BBB and recruiting new macrophages to sites of injury and inflammation (58). Several recent studies have also provided further support for the predominant role of macrophage-released factors on the recording function and the neuroinflammatory response.…”
Section: Discussionmentioning
confidence: 99%
“…[22] In addition to favourable mechanical properties, the surface chemistry of implanted electrodes has been studied to enhance biocompatibility. Functionalization with, or simultaneous administration of, penetrating electrodes with anti-inflammatory agents, [23] antioxidants, [24] neurogenic factors, [25] zwitterionic hydrogels, [26] and bioactive conducting polymers [27] has also been proposed to attenuate the foreign body response to implanted devices. In terms of device hardware, untethered and fully wireless cortical implants have been developed to alleviate displacement-induced strain and shear forces at the electrodetissue interface.…”
Section: Introductionmentioning
confidence: 99%
“…Increasing evidence suggests a dominant role of the neuroinflammatory response in mediating mechanical-, material- and biological-mediated failure of intra-cortical microelectrodes [1517]. Specifically, several groups have suggested a dominant role of microglia and infiltrating blood-derived cells in mediating the neuroinflammatory events following microelectrode implantation [1821]. …”
Section: Introductionmentioning
confidence: 99%
“…Building off the work from Tresco’s laboratory, Potter et al also suggested the role of extravasated serum proteins in propagating self-perpetuating neuroinflammatory events at the microelectrode-tissue interface by correlating chronic blood–brain barrier dysfunction with neurodegeneration directly surrounding the implanted microelectrodes [21]. Further, the authors also showed that preventing the accumulation of reactive oxygen species using resveratrol significantly improved blood–brain barrier integrity and neuronal viability [21].…”
Section: Introductionmentioning
confidence: 99%