The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Avnioğlu, Seda; Güngör, Meltem; Kurutaş, Ergül Belge; Öztürk, Ünal; Demirhan, Ilter; Bakarış, Sevgi; Çankaya, Şeyda; Yuluğ, Burak

doi:10.2478/rrlm-2021-0036

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…In addition, the most decrease in 8-iso-PGF2α value was observed in the combined treatment (RSV+B17) group (p<0.05). The antioxidant role of RSV is to compete with coenzyme Q, capture O2-(Superoxide radical) and inhibit lipid peroxidation (Avnioglu et al, 2022). In our study, the low levels of 8-iso-PGF2α in the treatment group may suggest that RSV inhibits lipid peroxidation as a strong antioxidant in vivo.…”

Section: Histopathological Resultsmentioning

confidence: 56%

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Protective Effect of Resveratrol and Vitamin B17 on 8-iso-Prostaglandin F2α and Raftlin-1 Levels in an Experimental Acute Urinary Retention in Rat

Demirhan

Kurutas

2022

IJAR

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Background: The incidence and complications of bladder disorders due to ischemia-reperfusion (I/R) injury constitute an important public health problem. The harmful effects of the disease could be reduced or completely eliminated by using natural antioxidant agents. In this study, the effects of preconditioning with Resveratrol and B17 vitamin, on bladder I/R damage was evaluated by the levels of 8-iso-prostaglandin F2α (8-iso-PGF2α) and raftlin-1 (RFTN-1) biomarkers. Methods: A total of 42 Wistar Albino male rats were used in the study which were divided in 6 groups (Group 1: Control, Group 2: Sham, Group 3: I/R, Group 4: Treatment 1 (RSV), Group 5: Treatment 2 (B17), Group 6: Combined treatment (RSV+B17). The effect of RSV and B17 valuated as the therapeutic group. Clamping the penile urethra of the rats, diuresis was forced and overdistension was achieved. After being kept in overdistension for 30 minutes, the rat bladder was emptied with a 3F catheter. The reperfused bladder was kept in this way for 30 minutes and the rats were sacrificed. 8-iso-PGF2α and RFTN-1 levels were measured in bladder tissue by ELISA. Result: In the I/R rat bladder tissue, we detected severe tissue injuries (p less than 0.05). As compared to the control group; It was observed that 8-iso-PGF2α and RFTN-1 values increased statistically significantly in sham, I/R and treatment 2 groups (p less than 0.05). 8-iso-PGF2α and RFTN-1 values were statistically significantly decreased in the therapeutic groups (Treatment 1, Treatment 2, Combined treatment compared to the I/R and sham group (p less than 0.05). A statistically significant decrease was observed in the treatment 1 group compared to the treatment 2 group in terms of 8-iso-PGF2α and RFTN-1 values (p less than 0.05).

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Section: Histopathological Resultsmentioning

confidence: 56%

“…Antioxidant substances containing phenolic compounds have positive effects on preventing ischemia-reperfusion or minimizing I/R damage (Avnioglu et al, 2022). Grape seed (RSV) contains high amounts of proanthocyanidins in terms of both quantity and quality.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Resveratrol and Vitamin B17 on 8-iso-Prostaglandin F2α and Raftlin-1 Levels in an Experimental Acute Urinary Retention in Rat

Demirhan

Kurutas

2022

IJAR

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“…With the re-initiation of blood flow in the ischemic tissue, ROS released into the environment by PMNL, which migrates and settles in the tissue, has an increased destructive effect on the tissue. Various studies have revealed that ROS performs an essential role in I/R injury by initiating lipid peroxidation (Avnioglu et al, 2021). At the same time, ROS increases tissue damage in the body by reacting with biomolecules.…”

Section: Histopathological Resultsmentioning

confidence: 99%

Effect of Curcuma longa on GPER-1 and Oxidative/Nitrosative Stress Biomarkers in Cardiac Ischemia-reperfusion Injury

IKIKARDES,

DEMIRHAN,

KURUTAS

2024

IJAR

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Background: The death rate caused by cardiovascular diseases is increasing all over the world. To investigate the cardioprotective effects of Curcuma longa on cardiac ischemia-reperfusion (I/R) injury, which was further examined through G protein-coupled estrogen receptor 1 (GPER-1) and oxidative/nitrosative stress biomarkers. Methods: Twenty-four male Wistar-albino rats were divided into three groups (I/R group; n=8, sham group; n=8, treatment (Curcuma longa) group; n=8). 1 ml Curcuma longa 50 mg/kg was administered intraperitoneally in the treatment group. While catalase, superoxide dismutase and malondialdehyde values were measured by spectrophotometric method, the measurement of GPER-1 was performed by ELISA method. In the histopathological examination, the groups were evaluated in terms of hemorrhage, myocardial edema, myocytolysis and polymorphonuclear leukocyte (PMNL) infiltration. Result: Statistically significant differences were observed between the treatment and I/R groups in terms of oxidative stress (malondialdehyde) level and antioxidant enzyme activities (catalase, superoxide dismutase) (p less than 0.05). The GPER-1 level was higher in the treatment group compared to the I/R group (p less than 0.05). Histopathologically, PMNL infiltration, hemorrhage, edema and myocytolysis were observed in the I/R and sham groups, whereas only hemorrhage was detected in the treatment group. This study showed that treatment with Curcuma longa inhibited lipid peroxidation by restoring existing antioxidant enzymes against cardiac ischemia-reperfusion injuries.

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“…By looking at the receptor and ligand structure, it is seen whether the compound carries a functional drug group [16]. Compounds containing the azomethine group (-HC=N-), which were first introduced by Hugo Schiff in 1864 and formed as a result of the reaction of a primary amine with an active carbonyl compound, and which are generally carried out by acid, base catalysis or heat, are called schiff bases [17,18]. Schiff bases are useful chelates because of their ease of preparation, structural variety, and steric and electronic control mechanisms [1].…”

Section: Introductionmentioning

confidence: 99%

“…Reactive oxygen species (ROS) are free radicals produced during oxidative metabolism. ROS can attack nucleic acid, lipids, proteins, polyunsaturated fatty acids and carbohydrates and induce their oxidation, which can lead to oxidative damage such as protein alteration, membrane dysfunction, enzymatic inactivation, and rupture of DNA strains [17]. Therefore, ROS must be cleared by cellular voters.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial Properties and In Silico Study of a N,N'-(ethane-1,2-diyl)bis(1-(9H-fluoren-2-yl)methanimine)

Demirhan

Öner

Necip

et al. 2022

International Journal of Life Sciences and Biotechnology

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ABSTRACT This study aimed to determine the antibacterial and antioxidant activities of the newly synthesized Schiff base and to support the laboratory results with molecular modeling studies. Antibacterial activity of schiff bases was demonstrated using Gram (-) Pseudomonas aeruginosa and Acinetobacter baumannii bacterial strains. Minimum Inhibition Concentration (MIC) values were determined to evaluate their antimicrobial activity against Gram-negative P. aeruginosa and A.baumanni bacterial strains. In antioxidant experiments, the responses to DPPH and ABTS radicals were calculated at certain concentration ranges and graphs were drawn. For the molecular modeling study, Autodock Vina and Discovery Studio 2020 package programs were used. The observed bacterial inhibition activity was variable depending on the clinical isolate and the concentration of the tested samples. The highest inhibition activity was achieved at concentration of 75 μl -100 μl. N,N'-(ethane-1,2-diyl)bis(1-(9H-fluoren-2-yl)methanimine) samples. Molecular docking results show that N,N'-(ethane-1,2-diyl)bis(1(9H-fluoren-2-yl) methanimine) binds strongly to the 4ZIY and 4ZHU structures. It has been proven by molecular docking study that the synthesized Schiff base ligand has antibiotic resistance properties. N, N'-(ethane-1,2-diyl)bis(1-(9Hfluoren-2-yl) methanimine) synthesis compound showed moderate activity against A. baumannii and P. aeruginosa strains. It is known that schiff bases have strong biological activities and show antibacterial activity. In this study, it can be said that the synthesis schiff base showed antibacterial and antioxidant activity. In addition, our results were supported by molecular modeling. Our findings can be taken to a higher level with in vivo and in vitro studies.

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The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Cited by 5 publications

References 34 publications

Protective Effect of Resveratrol and Vitamin B17 on 8-iso-Prostaglandin F2α and Raftlin-1 Levels in an Experimental Acute Urinary Retention in Rat

Protective Effect of Resveratrol and Vitamin B17 on 8-iso-Prostaglandin F2α and Raftlin-1 Levels in an Experimental Acute Urinary Retention in Rat

Effect of Curcuma longa on GPER-1 and Oxidative/Nitrosative Stress Biomarkers in Cardiac Ischemia-reperfusion Injury

Antioxidant, Antimicrobial Properties and In Silico Study of a N,N'-(ethane-1,2-diyl)bis(1-(9H-fluoren-2-yl)methanimine)

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