The effect of Rhazya stricta on glucose homeostasis in normal and streptozoticin diabetic rats

Wasfi, I.A.; Bashir, A. K.; Amiri, M. H.; Abdalla, A. A.

doi:10.1016/0378-8741(94)90011-6

Cited by 20 publications

(6 citation statements)

References 14 publications

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“…Animal studies showed controversial results. Wasfi et al reported no significant results [ 46 ]. However, Ali reported a significant decrease in the blood glucose level and an increase of insulin when using harmel and glibenclamide [ 47 ].…”

Section: The Most Used Tandcm Therapies In Saudi Arabiamentioning

confidence: 99%

A Descriptive Review of the Prevalence and Usage of Traditional and Complementary Medicine among Saudi Diabetic Patients

et al. 2018

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Diabetes mellitus represents a major burden in Saudi Arabia where seven million (20% of population) are living with diabetes. This article reviews the literature on usage of traditional and complementary medicine (T&CM) therapies among Saudi diabetic patients, focusing in particular on identifying the prevalence as well as discussing their safety and efficacy. Three databases (PubMed, Cochrane, and ScienceDirect) were searched prior to December 10, 2017, for articles published in peer-reviewed journals that reported primary data on the use of traditional and complementary medicine therapies among diabetic patients in Saudi Arabia. Six studies were selected according to the inclusion/exclusion criteria. In conclusion, the prevalence of use of T&CM therapies among diabetics in Saudi Arabia was 32.18%. This review identified that the most used T&CM therapy among diabetics was herbal treatment. The most used herbs were fenugreek, black seeds, neem, myrrh, helteet, harmel, and aloes. There is insufficient or little evidence to support the efficacy of the most identified herbs and therapies. This review is raising the safety concerns about the used herbs and complementary therapies which were commonly used without any medical consultation.

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Section: The Most Used Tandcm Therapies In Saudi Arabiamentioning

confidence: 99%

A Descriptive Review of the Prevalence and Usage of Traditional and Complementary Medicine among Saudi Diabetic Patients

et al. 2018

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“…Rhazya stricta Decne (family Apocynaceae) is a shrub with a smooth central stem and dense semi-erect branches (Western 1989) which grows commonly in the Al-Ain region. The plant is used in the United Arab Emirates as folk medicine in the treatment of diabetes mellitus, inflammatory conditions and helminthiasis.…”

Section: Introductionmentioning

confidence: 99%

“…The plant is used in the United Arab Emirates as folk medicine in the treatment of diabetes mellitus, inflammatory conditions and helminthiasis. Despite extensive phytochemical research on R. stricta (Baherji et al 1970;Rahman et al 1988;Bashir et al 1994), little work seems to have been published on the pharmacological properties of this plant (Wasfi et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Central Nervous System Activity of Rhazya Stricta (Decne) in Mice

Ali¹,

Bashir²,

Banna

et al. 1995

Clin Exp Pharma Physio

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1. The effects of orally administered aqueous lyophilized extract of the leaves of Rhazya stricta (2, 4 & 8 g/kg) on aspects of nervous system function were investigated in mice. 2. In three antinociceptive tests (hot plate, abdominal constriction, and warm water tail flick tests), the extract exhibited dose-dependent and significant antinociceptive activity. Naloxone was ineffective in antagonizing the analgesic effect of Rhazya stricta on tail-flick and abdominal constriction tests, possibly indicating that this effect occurs via non-opiate pathways. 3.Pretreatment of mice with the xenobiotic metabolizing enzymes inhibitor cimetidine (50 mg/kg) did not significantly alter the antinociceptive action of the extract, indicating that the effect is probably due to the parent compound(s) present in the extract and not to metabolites thereof. 4. Rhazya stricta produce dose-dependent sedation, decreased motor activity, and impaired motor control. Time spent on a rotarod treadmill was significantly decreased after treatment with the extract. 5. Rhazya stricta extract (8 g/kg) produced a degree of sedation comparable to that produced by diazepam (5-10 mg/kg), and also significantly increased the reaction time of the tail-flick test, an action which was not produced by diazepam. 6. Administration of R. stricta extract potentiated pentobarbitone sleeping time in a dose dependent manner. The extract did not significantly antagonize picrotoxin induced convulsions. The extract (4 and 8 g/kg) significantly decreased the rectal temperature of normothermic and hyperthermic mice. 7. Pretreatment with R. stricta extract (8 g/kg) completely prevented the occurrence of aggressive behaviour in male mice. 8. It is concluded that the crude extract of R. stricta has central nervous system depressant properties.

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“…Flavones, flavonoids, phenolics, terpenoids, isoflavones, plant steroids, indole acetic acid, isoprenoids, ethylene, jasmonic acids, ellagic acid and polyamines are well known natural products. The phytohormones constitute a group of compounds for plant growth, development, flowering, fruiting, pathogen resistance, and senescence (Muthuraman and Srikumar 2009;Wasfi et al 1992). The abundance of active endocrine substances has been reported in food as natural compounds (Hughes et al 1991).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells

Liu

Huang

et al. 2017

Cytotechnology

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The present study was aimed to investigate the effect of 28-homobrassinolide on leukotriene synthesis in the 2H3 cells. Cell viability was determined by using sulforhodamine B (SRB) assay. Leukotriene C (LTC4) and Leukotriene B4 (LTB4) were determined in the cell and cell lysates. Intracellular Ca was determined in the intact cells. Phospholipases A2 (PLA2) expression was determined in the cells using immunofluorescence. LTC4 and LTB4 were tremendously increased in IgE-loaded 2H3 cells. However, these levels were significantly reduced following treatment with 28-homobrassinolide. The intracellular Ca level was not altered by treatment. Expression of PLA2 was significantly reduced following treatment with 28-homobrassinolide. Taking all these data together, it is suggested that the 28-homobrassinolide may be a potential therapeutic agent to inhibit leukotriene synthesis in 2H3 cells.

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The effect of Rhazya stricta on glucose homeostasis in normal and streptozoticin diabetic rats

Cited by 20 publications

References 14 publications

A Descriptive Review of the Prevalence and Usage of Traditional and Complementary Medicine among Saudi Diabetic Patients

A Descriptive Review of the Prevalence and Usage of Traditional and Complementary Medicine among Saudi Diabetic Patients

Central Nervous System Activity of Rhazya Stricta (Decne) in Mice

Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells

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