The Effect of Rho Kinase Inhibitors on In Vitro Human Orbital Preadipocytes
David Yoo,
Meredith Horacek,
Min Kyung Chae
et al.
Abstract:Purpose:
To identify the effects of Rho Kinase (ROCK) inhibitor medications on human orbital adipogenesis, fibroblast proliferation, and fibrosis.
Methods:
Orbital adipose tissue was obtained from patients with Graves’ ophthalmopathy (GO) as well as controls (non-GO or normal) after informed consent was done. These tissue samples were cultured and adipogenesis was initiated. Levels of Rho Kinase as well as cellular mediators of orbital inflammation and … Show more
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