Background and Hypotheses: The contemporary research literature indicates that there is no significant clinical difference in terms of improvement of pain and functional disability between surgical repair and rehabilitation treatment for degenerative rotator cuff tears. It could be hypothesized that rehabilitation, which is cheaper and causes few complications, is preferable for smaller lesions, whereas surgical repair might be needed for the larger lesions. The purpose of our review was to assess whether the size of the tear, particularly the large or massive, plays a major role in terms of long-term clinical results for rehabilitation compared to surgical repair.Method: We searched the literature on PubMed, Embase, PEDro, and Cochrane Library database up to March 2020 for randomized controlled clinical trials that compared long term results for surgical vs. rehabilitation concerning large or massive degenerative rotator cuff tears. A systematic, critical review process was planned using a slightly modified SIGN checklist. The review methodology followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines and was submitted to PROSPERO and registered under the number CRD42020146161.Results: We found no randomized clinical trials that had dealt with this subject.Conclusion: There is no evidence that would help to choose between surgical repair or rehabilitation in case of large or massive rotator cuff degenerative tears. The reason for this is probably that large tears may be relatively painless since they often occur after retirement and therefore are relatively rarely seen in clinical practice. To obtain enough study subjects, it would therefore be necessary to study this question in multicenter randomized clinical trials.