The effect of saccharides on equilibrium swelling of thermo-responsive gels

Drozdov, Aleksey D.; Christiansen, Jesper de Claville

doi:10.1039/d0ra05845a

Cited by 6 publications

(8 citation statements)

References 72 publications

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“…In the case of hydrogel network, increasing temperature above VPTT breaks the cage‐like structure of hydrophobic segments in polymeric chains, inducing the hydrogel to contract. This contraction of hydrogel also exemplifies hydrophobicity when heated 177 . Grunlan et al suggested a double network (DN) PNIPAAm hydrogel system to enhance thermosensitivity compared to a single network (SN) hydrogel without increasing the VPTT 66 .…”

Section: Stimuli‐responsive Deformation Of Pillar Arrays and Its Applicationsmentioning

confidence: 98%

Fabrication and applications of stimuli‐responsive micro/nanopillar arrays

Park

Won

Cho

et al. 2021

Journal of Polymer Science

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The functional surface features of living creatures are driven by the complex morphology of periodically arranged micro/nanoscale structures. Various fabrication processes have been devised mimic the performance of natural features; these methods morph hierarchical and multi-leveled pillar arrays, such as top-down, bottom-up, and a hybrid of top-down and bottom-up processes.Different methodologies are employed depending on the materials, such as polymeric composites, metal oxides, metals, and carbon nanotubes. In this review, we discuss the shape-reconfiguration of stimuli-responsive micro/ nanopillar arrays achieved by capillary force, light, magnetic field, and heat. In particular, photo-and magnetic actuation of pillar arrays revealed programmability according to the arrangement of the liquid crystal molecules or magnetic particles by remote control. Furthermore, applications of micro/nanopillar arrays, such as adhesives, omniphobicity, optics, and biomedical technologies, are also discussed.

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Section: Stimuli‐responsive Deformation Of Pillar Arrays and Its Applicationsmentioning

confidence: 98%

Fabrication and applications of stimuli‐responsive micro/nanopillar arrays

Park

Won

Cho

et al. 2021

Journal of Polymer Science

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“…The list of cited works reports also theoretical papers where PDEs numerical methods and algorithms are described. The last type (type 3) of models is actually a large set of semi-empirical relationships available to correlate experimental data [25][26][27][28][29]. This approach appears intrinsically weak since it is not general based on first principles.…”

Section: Introductionmentioning

confidence: 99%

“…As such, they can be considered helpful tools to quickly identify peculiar system behaviours minimizing complexity. Their major strengths are (i) excellent reliability for specific applications, those for which they were tailored; (ii) easy implementation and (iii) quantitative results enabling data analysis at no Usually less detailed than type 1 but still first principle methods, hence also general but at lower degree of complexity (assumptions and empirical laws typically applied while ensuring enough accuracy) Computationally demanding (PDE have to be numerically solved; CFD commercial codes as well as ad hoc numerical methods are applied) [20][21][22][23][24] 3 Semi-empirical relationships tailored for specific cases; not general but versatile, flexible and non-time demanding; especially effective when limited experimental information is available; also useful to drive the experimental design Lack of generality [25][26][27][28][29][30] computational cost. Combined with a reasonable experimental campaign, these correlative models are well established and widely accepted in the literature.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modelling of cross-linked polyacrylic-based hydrogels: physical properties and drug delivery

Bisotti

Pizzetti

Storti

et al. 2022

Drug Deliv. and Transl. Res.

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Recently, hydrogels have gained significant importance in different applications, such as tissue engineering and drug delivery. They are 3D structures of hydrophilic polymers held together through physical or chemical crosslinking. Important is their ability to swell in presence of solvents, forming elastic gels able to maintain their original shape. Furthermore, these scaffolds slowly degrade in the physiological environment, leading the growing tissue to replace the former filled site. In this work, hydrogels have been synthetized using branched polyacrylic acid (carbomer) cross-linked with an aliphatic polyetherdiamine (elastamine). In particular, we focused on the description of their equilibrium conditions in swollen state and the dynamic simulation of the swelling process. These hydrogels exhibited a peculiar swelling behaviour characterized by an overshoot of the volume increase before reaching the equilibrium. Notably, such behaviour was found at different pH values. In this manuscript, the swelling behaviour was studied by mathematical modelling. Moreover, the ability of these devices to release drugs was also examined through a literature model to understand the different operating transport mechanisms.

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“…In this context, it is worth studying the specific effect of this biologically relevant sugar on the collapse of PNIPAM-based architectures. The PNIPAM-watertrehalose ternary system is much less investigated both experimentally and numerically as compared to any other ternary system of the same polymer, including those containing saccharides [44][45][46][47][48][49]. Experimental investigations using cloud point measurements, differential scanning and isothermal titration-microcalorimetry [44,46], report a significant decrease of LCST of PNIPAM chains in aqueous solution on increasing mono-and disaccharide concentration, finding a good correlation of the saccharide hydration with the decrease of LCST, and hence with the promotion of the globular compact state of the polymer.…”

Section: Introductionmentioning

confidence: 99%

“…The effect of saccharides has also been studied on another type of PNIPAM-based system, i.e. hydrogels, by evaluating the influence on the VPTT and swelling behavior, also in this case with a focus on the water-saccharide interactions [45,47,49]. To our best knowledge, however, only very few studies refer to trehalose.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsivity of poly(N-isopropylacrylamide) microgels in water-trehalose solution and its relation to protein behavior

Rosi,

Tavagnacco,

Comez

et al. 2021

Preprint

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In this work we use a multi-technique approach to gain new insights into the effects of trehalose on the volume phase transition of poly(N-isopropylacrylamide) (PNIPAM) microgels, a model synthetic biomimetic system. By dynamic light scattering the temperature-dependent microgel hydrodynamic volume is monitored, while Raman spectroscopy and molecular dynamics simulations explore at the molecular scale changes of solvation and dynamics across the transition. At 0.72 M trehalose concentration the phase transition temperature is lowered by ≈ 10 K, with a concomitant decrease of transition enthalpy not compensated by a corresponding reduction in transition entropy. In water-trehalose solution the microgel particles are ≈ 20% more expanded than in pure water, keeping unchanged their thermal contraction, swelling capacity, and the amount of absorbed water. Strongly hydrated trehalose molecules mainly develop water-mediated interactions with PNIPAM, thus preserving the polymer hydration state both before and after the transition. However, the presence of trehalose deeply impacts on the dynamics of the system, with a drastic slowing down of PNIPAM motions and of its hydration shell. Our investigation reveals a coherent picture in which trehalose sustains hydration and favors, both thermodynamically and kinetically, the collapsed conformation of the microgel, by inhibiting local motions of polymer residues and water.

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The effect of saccharides on equilibrium swelling of thermo-responsive gels

Abstract: A model is developed for the mechanical response and equilibrium swelling of thermo-responsive gels and applied to the analysis of their volume phase transition in aqueous solutions of saccharides.

Cited by 6 publications

References 72 publications

Fabrication and applications of stimuli‐responsive micro/nanopillar arrays

Fabrication and applications of stimuli‐responsive micro/nanopillar arrays

Mathematical modelling of cross-linked polyacrylic-based hydrogels: physical properties and drug delivery

Thermoresponsivity of poly(N-isopropylacrylamide) microgels in water-trehalose solution and its relation to protein behavior

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