The Effect of Saffron (<i>Crocus sativus L. Iridaceae</i>) Orally Administration on Blood Level of Sex Hormones in Rats

Abstract

Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied in folk medicine in a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) is of particular importance. This paper presents the results of study of the effects of Azerbaijan-grown saffron on blood level of follicle-stimulating hormone (FSH) in female rats, as well as on blood level of testosterone in male rats. In the blood serums of animals, using hormonal test systems for enzyme immunoassay, FSH and testosterone levels were determined. The findings revealed a decrease in blood levels of FSH in 12-month-old female rats as compared to the control group (comprising animals of the same age which did not receive the saffron extract), as they approximated the registered levels of 6-month-old female rats. Saffron increased the blood level of testosterone as compared to untreated controls, which did not receive saffron. Saffron's unique medicinal properties largely owe to the diversity of biologically active substances it contains The effects of saffron treatment observed in the course of this study could be explained by the direct impact of saffron and its components on the sex glands and the central nervous system. Findings of diverse pharmacological effects of the saffron extract open new horizons for the development of scientifically corroborated recommendations for application in practical medicine.