The Effect of Saffron (Crocus Sativus) Extract for Healing of Second-degree Burn Wounds in Rats

Khorasani, Ghasemali; Hosseinimehr, Seyed Jalal; Zamani, P.; Ghasemi, Maryam; Ahmadi, Amirhossein

doi:10.2302/kjm.57.190

Cited by 77 publications

(61 citation statements)

References 12 publications

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“…[64] Saffron extract as topical cream was applied 24 h after thermal induced burn wounds, in comparison with sil¬ver sulfadiazine (SSD). Animals were divided into four groups: control, base, saffron (20%) or SSD (1%).…”

Section: Other Actionsmentioning

confidence: 99%

Saffron: a natural product with potential pharmaceutical applications

Christodoulou

Kadoglou

Kostomitsopoulos

et al. 2015

Journal of Pharmacy and Pharmacology

177

101

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Objectives Recently, a great deal of interest has been developed to isolate and investigate novel bioactive components from natural resources with health beneficial effects. Saffron is the dried stigma of Crocus sativus L. and has been used for centuries in traditional medicine mainly for its healing properties, as well as for the treatment of various pathological conditions. Objectives of the present review are to unravel its therapeutic properties and investigate the potential applications of saffron in contemporary therapy of a wide spectrum of diseases and summarize previous and current evidence regarding the biological/pharmacological activities of saffron and its active ingredients and their possible therapeutic uses. Key findings Recent phytochemistry and pharmacological experiments have indicated that crocin and safranal, the major active ingredients of saffron, exert important actions, such as antioxidant, anti-tumor, anti-diabetic, anti-inflammatory and anti-atherosclerotic. Unfortunately, the vast majority of those data derive from in vitro studies, whereas a limited number of in vivo experiments support the aforementioned effects. In addition to studies with mechanistic implications, very few clinical trials provide preliminary evidence of saffron potentiality to alleviate depression and increase cognitive function in patients with Alzheimer's disease. Summary The history and structural features of saffron constituents are given in the first part of the review, followed by a comprehensive and critical presentation of the published preclinical and clinical studies and review papers on the pharmacology and possible therapeutic uses of saffron and its main active components crocin and safranal.

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Section: Other Actionsmentioning

confidence: 99%

Saffron: a natural product with potential pharmaceutical applications

Christodoulou

Kadoglou

Kostomitsopoulos

et al. 2015

Journal of Pharmacy and Pharmacology

177

101

View full text Add to dashboard Cite

show abstract

“…[3][4][5] Exposure to hot water is one of the most frequent causes of burns. 6 All wounds will have some bacterial colonization. Staphylococcus aureus bacteria are early colonizers, and account for the majority of burn-wound infections; moreover, they are responsible for many other skin and soft-tissue infections in humans, including impetigo, folliculitis, cellulitis, and submit your manuscript | www.dovepress.com…”

Section: Introductionmentioning

confidence: 99%

Photodynamic antimicrobial chemotherapy for <em>Staphylococcus aureus</em> and multidrug-resistant bacterial burn infection in vitro and in vivo

Mai¹,

Gao²,

Li³

et al. 2017

IJN

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Background and objectives Antibiotic resistance has emerged as one of the most important determinants of outcome in patients with serious infections, along with the virulence of the underlying pathogen. Photodynamic antimicrobial chemotherapy (PACT) has been proposed as an alternative approach for the inactivation of bacteria. This study aims to evaluate the antibacterial effect of sinoporphyrin sodium (DVDMS)-mediated PACT on Staphylococcus aureus and multidrug resistant S. aureus in vitro and in vivo. Materials and methods Bacteria were incubated with DVDMS and exposed to treatment with light. After PACT treatment, colony-forming units were counted to estimate the bactericidal effect. Intracellular reactive oxygen-species production was detected by flow cytometry. Flow cytometry and fluorescence-microscopy detection of bacterial cell-membrane permeability. Enzyme-linked immunosorbent assays were used to determine expression of VEGF, TGFβ 1 , TNFα, IL6, and bFGF factors in burn infection. Results DVDMS-PACT effectively killed bacterial proliferation. Intracellular ROS levels were enhanced obviously in the PACT-treatment group. SYTO 9 and propidium iodide staining showed a decrease in the ratio of green:red fluorescence intensity in the PACT-treatment group in comparison to the control group. Enzyme-linked immunosorbent-assay results revealed that in the healing process, the expression of bFGF, TGFβ 1 , and VEGF in the treatment group were higher than in the control group, which inhibited inflammation-factor secretion. In addition, skin-tissue bacteria were reduced after treatment. Conclusion These results indicate that DVDMS-PACT presents significant bactericidal activity and promotes wound healing after burn infections.

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“…The important function of oxidative stress in the pathophysiological process of liver injury and fibrosis induced by biliary occlusion is one of the most studied aspects of cholestatic liver injury treatment (Khorasani et al, 2008;Hayat et al, 2011). Previous studies (LaLonde et al, 1997;Konishi et al, 2006;Nagi et al, 2010) show that model rats with bile duct ligation have pathological features similar to those of human cholestatic liver injury.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of thymoquinone on cholestatic rats with liver injury

Kong

Yang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the protective effects of thymoquinone treatment on cholestatic rats with liver injury. Thirty-two Sprague-Dawley rats were divided randomly into four groups: normal control, bile duct ligation model control, low-dose thymoquinone (25 mg/kg), and high-dose thymoquinone (50 mg/kg). Thymoquinone gavage was administered continuously 3 days before bile duct ligation, and saline, at the same volume, was administered to the control group. The rats were sacrificed after 2 weeks of treatment, and the liver tissues were obtained and frozen. The contents of hydroxyproline (HP), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the homogenate of the liver tissues were determined to evaluate the changes in hepatic tissue pathology by fibrosis scoring. The HP and MDA levels were significantly lower and the SOD and GPx levels were significantly higher in the thymoquinonetreatment group than the corresponding levels in the model control (2015) group, and the differences were statistically significant (P < 0.05) and dose-dependent. The hepatic necrosis areas and hepatic fibrosis scores of the thymoquinone-treatment groups were significantly lower than those of the model group (P < 0.05). Thymoquinone increased the antioxidative capacity of liver and reduced the oxidative stress damage to the liver. Thymoquinone can be used as a liver protectant in patients with cholestasis.

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The Effect of Saffron (Crocus Sativus) Extract for Healing of Second-degree Burn Wounds in Rats

Cited by 77 publications

References 12 publications

Saffron: a natural product with potential pharmaceutical applications

Saffron: a natural product with potential pharmaceutical applications

Photodynamic antimicrobial chemotherapy for <em>Staphylococcus aureus</em> and multidrug-resistant bacterial burn infection in vitro and in vivo

Protective effect of thymoquinone on cholestatic rats with liver injury

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