The Effect of Sagunja Decoction on Functional Dyspepsia - A Systematic Review and Meta-Analysis

Abstract

Objectives: This study examines the effect of Sagunja-tang on functional dyspepsia (FD) through a systematic review and meta-analysis of a randomized controlled trial (RCT). Methods: A search for RCTs that tested the effect of Sagunja-tang on functional dyspepsia was conducted in Medline, Embase, PubMed, CENTRAL, CiNii, CNKI, NDSL, RISS, OASIS, and KISS databases on November 8, 2020, with no limit on the year of publication. A meta-analysis was performed by synthesizing the findings, including total efficiency, clinical symptom score, myosin light-chain kinase (MLCK) level (pg/mL, and gastric half-emptying time (min). RevMan 5.4.1 software was used for data analysis. The quality of the literature was evaluated using Cochrane’s risk of bias (RoB) tool. Results: A total of 14 RCTs met the selection criteria. As a result of the meta-analysis, the treatment group had higher total efficacy and MLCK levels (gastric antrum, jejunum) than the control group, and the clinical symptom score and gastric half-emptying time were lower. However, due to the low quality of the included RCT and the small sample size, the results may be slightly biased.

A Case Report on Functional Dyspepsia Treated with Korean Medicine in a Patient with Panic Disorder and Lower Back Pain

“…脘痛 등의 병증에 해당하며, 한의학적 발생 기전은 脾胃氣虛를 바탕으로 氣滯, 食積, 痰飮, 濕熱 등이 서로 뒤섞이며 나타나거나 虛實寒熱이 동시에 보 이기도 한다 3 . 기능성 소화불량에 대한 약물 치료 로는 四君子湯 4 , 六君子湯 5 등을 사용한 연구들이 발표되었으며, 김 등 6 의 연구에서 기능성 소화불량 증에 사용된 침구 치료 방법에 대한 체계적 문헌 고찰이 이루어지는 등 한의학적 치료의 효과를 증 명하는 연구가 꾸준히 이루어지고 있다.…”