The Effect of Selenium on Endometrial Repair in Goats with Endometritis at High Cortisol Levels

The effect and mechanism of selenium supplementation on the proliferation capacity of bovine endometrial epithelial cells exposed to lipopolysaccharide in vitro under high cortisol background

“…Combined with the results of the cell cycle, cell scratch, and EdU assay, Se contributed to the uterine repair by decreasing LPS-induced cell apoptosis and promoting cell proliferation through the PI3K/AKT and Wnt/β-catenin signaling pathways at high COR levels. Similarly, some studies have shown that the PI3K/AKT and Wnt/β-catenin signaling pathways are also involved in the regulation of Se on the liver health and metabolism of the broiler, and the uterine repair of goats ( Li et al, 2023a , 2023b ).…”

“…Goats and cows are both ruminants and share some similarities. A recent study revealed Se supplementation reduced the inflammatory response and promoted endometrial tissue repair by activating the PI3K/AKT and Wnt/β-catenin signaling pathways in goats ( Li et al, 2023a ). Given the ability of Se to regulate inflammation and cell proliferation, researchers have been developing selenium-containing drugs to prevent and treat disease.…”

“…Se supplementation has been shown to reduce the time of bovine uterine involution ( Harrison et al, 1986 ). In goats, Se supplementation can increase the proliferation and decrease the apoptosis of endometrial cells to promote endometrial tissue repair ( Li et al, 2023a ). In cows, Se supplementation reduces the oxidative stress-induced apoptosis of bovine mammary epithelial cells and increases cell proliferation ( Miranda et al, 2011 ).…”

Development potential of selenium in the prevention and treatment of bovine endometritis

“…In vitro, there are differences in antioxidant capacity and the level and range of effects on inflammatory pathways according to the Se concentration (Hoffmann & Berry, 2008;Zhang et al, 2022). A recent study found that organic Se supplementation reduced the %PMN of uterine secretions and the inflammatory response in a goat model of endometritis (Li et al, 2023). Yet, the exact tation inhibits these effects (Zhang et al, 2015).…”

“…These results indicated that Se supplementation may promote uterine repair in cows with endometritis. Similarly, organic Se supplementation increases the proliferation and decreases the apoptosis of endometrial cells to promote endometrial tissue repair in goats with endometritis at high cortisol levels (Li et al, 2023). Yet, long-term changes in the endometrium are not studied in this paper.…”