The effect of selenium on infertility in ewes grazing improved pastures

Godwin, K. O.; Kuchel, RE; Buckley, RA

doi:10.1071/ea9700672

Cited by 27 publications

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“…1) was rapid compared with that observed in mature ewes transferred from normal pastures to selenium-low pastures in the same area from which feed used in these experiments was harvested (Godwin et al 1970). The level of 0·02 f-tg/ml reached in animals not slaughtered until 18 weeks confirms the observations of the New Zealand workers (Hartley 1967) that sheep suffering from selenium-responsive disease have blood levels of selenium as low as 0·02 fLg/ml.…”

Section: Discussionsupporting

confidence: 74%

Some Biochemical Features of White Muscle Disease in Lambs, and the Influence of Selenium

Godwin¹,

Kuchel²,

Fuss³

1974

Aust. Jnl. Of Bio. Sci.

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Typical white muscle disease has been induced in lambs that were normal at weaning but thereafter fed natural dystrophogenic fodder for 2-4 months. Protection from the disease was given by selenium when it was administered regularly as an oral drench, or incorporated into an intraruminal heavy pellet placed in the rumen at weaning.Calcium and magnesium levels in serum were unaffected by the dystrophic condition, although urinary excretion of both ions was decreased. This lowered urinary excretion was associated with high levels of calcium in both heart and skeletal muscle, and to some extent associated with raised levels of calcium and magnesium in washed mitochondria isolated from the same tissues.The respiratory properties of the mitochondria were examined polarographically. No differences were found between heart muscle mitochondria isolated from normal and dystrophic hearts. Skeletal muscle mitochondria from dystrophic animals showed lowered respiratory rates with palmitoyl-DL-carnitine and acetyl-DL-carnitine as substrates. The smaller differences with pyruvate and succinate were not significant. Respiratory control ratios for the dystrophic skeletal muscle organelles were always 1 . 0, but for selenium-supplemented animals were always > 1 ·0.To some extent at least the abnormalities appear to be associated with the high levels of calcium in the tissues and mitochondria of dystrophic lambs.

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Section: Discussionsupporting

confidence: 74%

Some Biochemical Features of White Muscle Disease in Lambs, and the Influence of Selenium

Godwin¹,

Kuchel²,

Fuss³

1974

Aust. Jnl. Of Bio. Sci.

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“…In agreement with the present study, specific degrees of Se-deficiency in beef cattle generally has not affected reproduction (Hidiroglou, 1982). However, Se supplementation of Se-defi-cient diets has improved reproductive efficiency of sheep in some studies (Hartley, 1963;Godwin et al, 1970;Segerson and Ganapathy, 1980;Wilkins and Kilgour, 1982) but not in others (Hidiroglou, 1982).…”

Section: Resultsmentioning

confidence: 99%

Effects of Marginal Selenium Deficiency and Winter Protein Supplementation on Growth, Reproduction and Selenium Status of Beef Cattle

Spears

Harvey

Segerson

1986

Journal of Animal Science

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Seventy-two Hereford X Simmental cows, averaging 498 kg in body weight and 5.2 yr of age, were used in a 2-yr study to ascertain if selenium (Se)-vitamin E (E) injections and winter protein supplementation would affect growth, reproduction and health of beef cattle maintained year-round on feedstuffs marginally deficient in Se (.03 to .05 mg/kg). Cows received either no injection or a mixture of 30 mg Se (as sodium selenite) and 408 IU E injected subcutaneously beginning 3 to 4 mo prepartum and at 60-d intervals throughout the 2-yr period. Calves born to Se-E treated cows were injected with 5.5 mg Se and 75 IU E/100 kg body weight at 60-d intervals beginning at 1 mo of age. Calves were born between December 30 and February 20 and cows were bred between March 20 and May 20. Cattle grazed pasture (.05 mg Se/kg) that consisted of orchardgrass, bluegrass and white clover during the fall, spring and summer. During winter (December 15 to May 2), cattle were fed corn silage (.03 mg Se/kg) supplemented with either: no protein supplement (control), soybean meal or a urea-corn mixture. Cows and calves receiving Se-E had higher (P less than .01) whole blood glutathione peroxidase (GSH-Px) activity and plasma Se concentrations than controls. Selenium-E injections reduced (P less than .05) calf death losses from 15.3% to 4.2% and slightly increased (P less than .10) adjusted calf weaning weights. Hemoglobin concentrations were higher (P less than .05) in Se-E-injected supplemented calves at 1 mo of age but not at 5 or 7 mo of age.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Se deficiency has been found in some regions in the world. Se supplementation is required for people in those areas to prevent various types of diseases, such as man reproduction, cancer, and neurodegenerative diseases [ 1 – 6 ]. The biological effect of selenium in human health is mainly executed via selenoproteins in which Se presents in the form of selenocysteine (Sec), the 21st essential amino acid.…”

Section: Introductionmentioning

confidence: 99%

Galectin-1 Is an Interactive Protein of Selenoprotein M in the Brain

Qiao

Tian

Chen

et al. 2013

IJMS

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Selenium, an essential trace element for human health, mainly exerts its biological function through selenoproteins. Selenoprotein M (SelM) is one of the highly expressed selenoproteins in the brain, but its biological effect and molecular mechanism remain unclear. Thus, the interactive protein of SelM was investigated in this paper to guide further study. In order to avoid protein translational stop, the selenocysteine-encoding UGA inside the open reading frame of SelM was site-directly changed to the cysteine-encoding UGC to generate the SelM′ mutant. Meanwhile, its N terminal transmembrane signal peptide was also cut off. This truncated SelM′ was used to screen a human fetal brain cDNA library by the yeast two-hybrid system. A new interactive protein of SelM′ was found to be galectin-1 (Gal-1). This protein-protein interaction was further verified by the results of fluorescence resonance energy transfer techniques, glutathione S-transferase pull-down and co-immunoprecipitation assays. As Gal-1 plays important roles in preventing neurodegeneration and promoting neuroprotection in the brain, the interaction between SelM′ and Gal-1 displays a new direction for studying the biological function of SelM in the human brain.

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The effect of selenium on infertility in ewes grazing improved pastures

Cited by 27 publications

References 0 publications

Some Biochemical Features of White Muscle Disease in Lambs, and the Influence of Selenium

Some Biochemical Features of White Muscle Disease in Lambs, and the Influence of Selenium

Effects of Marginal Selenium Deficiency and Winter Protein Supplementation on Growth, Reproduction and Selenium Status of Beef Cattle

Galectin-1 Is an Interactive Protein of Selenoprotein M in the Brain

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