The effect of self-inflicted burns on ABSI score prediction power: A four-year prospective multicenter study of the German Burn Registry

Billner, Moritz; Reif, Simon; Registry, German Burn; Reichert, Bert

doi:10.1016/j.burns.2021.11.016

Cited by 3 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We confirmed that the nomogram was an independent prognostic value in multivariate logistic analysis. TBSA, ABSI, and Baux were often used to assess the severity and prognosis of burn patients ( 48 , 49 ). Some researchers have also constructed prognostic models related to age, gender, length of hospital stay, and inhalation injury.…”

Section: Discussionmentioning

confidence: 99%

Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns

Wang¹,

Zhang²,

Lin³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

IntroductionViral infection, typically disregarded, has a significant role in burns. However, there is still a lack of biomarkers and immunotherapy targets related to viral infections in burns.MethodsVirus-related genes (VRGs) that were extracted from Gene Oncology (GO) database were included as hallmarks. Through unsupervised consensus clustering, we divided patients into two VRGs molecular patterns (VRGMPs). Weighted gene co-expression network analysis (WGCNA) was performed to study the relationship between burns and VRGs. Random forest (RF), least absolute shrinkage and selection operator (LASSO) regression, and logistic regression were used to select key genes, which were utilized to construct prognostic signatures by multivariate logistic regression. The risk score of the nomogram defined high- and low-risk groups. We compared immune cells, immune checkpoint-related genes, and prognosis between the two groups. Finally, we used network analysis and molecular docking to predict drugs targeting CD69 and SATB1. Expression of CD69 and SATB1 was validated by qPCR and microarray with the blood sample from the burn patient.ResultsWe established two VRGMPs, which differed in monocytes, neutrophils, dendritic cells, and T cells. In WGCNA, genes were divided into 14 modules, and the black module was correlated with VRGMPs. A total of 65 genes were selected by WGCNA, STRING, and differential expression analysis. The results of GO enrichment analysis were enriched in Th1 and Th2 cell differentiation, B cell receptor signaling pathway, alpha-beta T cell activation, and alpha-beta T cell differentiation. Then the 2-gene signature was constructed by RF, LASSO, and LOGISTIC regression. The signature was an independent prognostic factor and performed well in ROC, calibration, and decision curves. Further, the expression of immune cells and checkpoint genes differed between high- and low-risk groups. CD69 and SATB1 were differentially expressed in burns.DiscussionThis is the first VRG-based signature (including 2 key genes validated by qPCR) for predicting survival, and it could provide vital guidance to achieve optimized immunotherapy for immunosuppression in burns.

show abstract

Section: Discussionmentioning

confidence: 99%

Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns

Wang¹,

Zhang²,

Lin³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Attempted Suicide by Burning: A Cross-sectional Analysis at a Regional Burn Center in Germany

Obed

Dastagir

Salim

et al. 2022

Journal of Burn Care &Amp; Research

View full text Add to dashboard Cite

Attempted suicide by self-immolation or burning constitutes an uncommon form of attempted suicide in high income countries, presenting substantial challenges to burn units. The aim of this study was to analyze the epidemiologic characteristics and outcomes in intensive care burn patients treated for attempted suicide by burning. For this purpose, we examined intensive care burn patients admitted to a single major burn unit between March 2007 and December 2020. Demographic, clinical, epidemiological and mortality data were collected and analyzed. Major psychiatric comorbidities were evaluated according to ICD-9 and ICD-10 classifications. A total of 1325 intensive care unit burn patients were included. Suicide by burning was attempted in 45 cases (3.4%). Attempted suicide victims presented with significantly higher burn severity, reflected by higher abbreviated burn severity index scores and larger total body surface area affected. Burned total body surface area ≥30% and inhalation injuries were observed more frequently in suicidal patients. These patients also experienced prolonged hospital and intensive care unit length of stay, required more frequent surgical interventions and mechanical ventilation more frequently and had significantly longer periods on ventilation, causing an overall higher mortality rate (24.4%). Psychiatric comorbidities were present in 75.6% of patients who attempted suicide. Despite the low prevalence, burn severity and mortality are considerably high in patients who attempted suicide by burning, presenting a significant challenge for healthcare providers. The majority of patients had a history of psychiatric disorder, highlighting the importance of identifying patients at high-risk who may profit from increased psychiatric intervention.

show abstract

In-hospital Mortality Following Suicidal Burns: A Propensity Score-Matched Analysis

Obed

Gruber

Salim

et al. 2023

Journal of Burn Care &Amp; Research

View full text Add to dashboard Cite

We carried out a retrospective single-center study and analyzed all patients who have been admitted to our intensive care burn unit following suicide attempt and accidental burns within 14 years. Clinical and demographic parameters were collected and evaluated. Propensity score matching was performed in order to minimize the confounding effect of the parameters age, sex, total body surface area (TBSA) and the presence of full-thickness burns and inhalation injury. 45 burn patients following attempted suicide by burning and 1266 patients following accidental burn injury were admitted. Patients with suicidal burn injuries were significantly younger and showed significantly higher burn severity, reflected by larger TBSA affected, higher incidence of full-thickness burns and inhalation injury. They also experienced increased hospital length of stay and longer ventilation durations. Their in-hospital mortality was significantly higher. Following propensity score matching in 42 case pairs, no differences were detected with regard to in-hospital mortality, hospital length of stay, duration of mechanical ventilation and frequency of surgical interventions. Attempted suicide by burning is associated with overall worse outcomes and higher mortality rates. Following propensity score matching, significant differences in outcomes were no longer detectable. Given the comparable survival probability compared to accidentally burned patients, life-sustaining treatment should not be withheld in burn patients following suicide attempt.

show abstract

The effect of self-inflicted burns on ABSI score prediction power: A four-year prospective multicenter study of the German Burn Registry

Cited by 3 publications

References 22 publications

Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns

Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns

Attempted Suicide by Burning: A Cross-sectional Analysis at a Regional Burn Center in Germany

In-hospital Mortality Following Suicidal Burns: A Propensity Score-Matched Analysis

Contact Info

Product

Resources

About