The objective of this work is to establish the design principles for a proton exchange membrane fuel cell in automotive applications. In this work, the macro-scale analysis was considered to create the overall design principle. A combination of experiments and numerical simulations were carried out and the results analyzed to enhance understanding of the behavior of the large-scale 300-cm 2 proton exchange membrane fuel cell under automotive operations. A three-dimensional computational fluid dynamicsbased methodology was used to predict such as the current and temperature distributions of this design as a function of anode relative humidity. The effect of flow direction and the cooling pattern on this design was also taken into account to enhance the understanding for this selected flow-field design. The predictions show that the gas flow and cooling directions are important dependent variables that can impact the overall performance and local distributions. As the increased number of power generators utilizing fossil fuel energy increases in many applications, the necessity for alternatives to the internal-combustion engine become even more obvious. Automakers and industrial developers are investigating many ways to significantly reduce emissions for stationary and transportation applications, Proton Exchange Membrane Fuel Cells (PEMFCs) are now widely seen as a possibility. Distributions in reactant species concentration in a PEMFC cause distributions in local current density, temperature and water over the area of a PEMFC. These can lead to locally negative effects such as excessive hydration or dehydration in the PEMFC thus causing stresses in effective regions of the fuel cell. Changing operating conditions and design parameters including their properties inside PEMFC system such as flow field configurations, gas diffusion layer (GDL), and membrane electrode assembly (MEA) could vary uniformity in distribution and impact the fuel cell performance and durability. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The inherent non-linearity of the equations governing PEMFC performance on a three-dimensional level requires iterative solution techniques. Solving a full three-dimensional CFD model for the flow channel and diffusion layers of a PEMFC shows important interactions of porous media and flow-field design that affect distributions of current, temperature, and species transport as discussed in numerous literature for the past ten years. This type of model lends itself well to investigating the physics inside full-scale PEMFCs. 1,2,6,10,23,24 In this work, three-dimensional (3D) CFD simulations of PEMFC were performed for a full size single cell with 300 cm 2 active area. An ultimate purpose of this study was to establish a model-based engineering capability to design the PEMFC for targeted applications. For this time, robustness of the fuel cell performance was investigated with various operating conditions which can impact the water management problems in the PEMFC. 25,26 Especially, relative hu...