The effect of sertindole on behavioural sensitisation to methamphetamine in mice

Landa, Leoš; Šlais, Karel; Šulcová, Alexandra

doi:10.17221/6468-vetmed

Cited by 3 publications

(7 citation statements)

References 30 publications

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“…This is in accordance with our findings where repeated pre-treatment with the methamphetamine+memantine combination blocked the development of behavioural sensitisation to methamphetamine. On the other hand, the results obtained by Aguilar et al (2009) are in contradiction with our previous results obtained in the study with another NMDA receptor antagonist felbamate (Landa et al 2012), where pre-treatment with felbamate+methamphetamine resulted, after the methamphetamine challenge dose, in the development of sensitisation to the stimulatory effects of methamphetamine.…”

Section: Discussioncontrasting

confidence: 95%

“…This result is in accordance with the majority of similar experiments reporting the inhibitory effects of NMDA receptors antagonists on the development of sensitisation to amphetamines (Wolf 1998). The findings obtained in this experiment are also to a certain extent in compliance with our previous study where we tested the possible influence of another NMDA receptor antagonist, felbamate, on behavioural sensitisation to methamphetamine (Landa et al 2012). This substance also inhibited, even in a more pronounced manner, sensitisation in mice repeatedly pre-treated with methamphetamine that were given a methamphetamine challenge dose together with felbamate.…”

Section: Discussionsupporting

confidence: 93%

“…Landa et al 2006aLanda et al ,b, 2011Landa et al , 2012. In our experimental design we focused also on the expression of behavioural sensitisation and although there was a clear trend towards an increase in locomotion in mice after the second methamphetamine challenge dose when compared to sensitised animals, it did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 95%

“…It has been described in both laboratory animals and man (Tzschentke and Schmidt 1997;Steketee and Kalivas 2011). Behavioural sensitisation was, for example, re-ported for cocaine (Schroeder et al 2012;Ramos et al 2012), methylphenidate (Freese et al 2012), morphine (Hofford et al 2012), ethanol (Pastor et al 2012) and methamphetamine (Horio et al 2012;Landa et al 2011Landa et al , 2012.…”

mentioning

confidence: 99%

“…In our previous study we tested the effect of the activating antiepileptic drug felbamate (that acts as an NMDA receptor antagonist) on behavioural sensitisation to methamphetamine (Landa et al 2012). Another substance that also blocks NMDA glutamate receptors is memantine.…”

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confidence: 99%

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The effect of memantine on behavioural sensitisation to methamphetamine in mice

Landa¹,

Šlais²,

Šulcová³

2012

Vet. Med. - Czech

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After repeated administration the psychostimulant methamphetamine (Met) produces a substantial increase in behavioural responses, which is termed behavioural sensitisation. Many studies have reported that N-methyl-d-aspartate (NMDA) receptors play an important role in the development and expression of behavioural sensitisation. Memantine (Mem) is used particularly for the treatment of Alzheimer's disease and acts as a non-competitive NMDA glutamate receptor antagonist, possessing a variety of psychotropic effects. For example, there are studies indicating that memantine prevents the expression of withdrawal symptoms in mice and causes reversal of opioid dependence. Although not all pharmacological mechanisms of memantine have been clarified yet, it is known that memantine inhibits NMDA receptor inward currents. Thus, the present study was designed to assess whether memantine would influence behavioural sensitisation to the stimulatory effects of methamphetamine on mouse locomotion. Mice were randomly allocated into four groups. They were given vehicle on Day 1of the experiment and after five days without application they were administered seven drug daily doses (i.p.) from Day 7 to Day 13 of the study, as follows: (a) n 1, 2 : 2.5 mg/kg/day of Met; (b) n 3 : combination Met + Mem at the doses of 2.5 mg/kg/day and 5 mg/kg/day, respectively; (c) n 4 : Mem at the dose of 5 mg/kg/day. On Day 14 mice were given the first "challenge treatment" (a) n 1 : Met, (b) n 2 : Met + Mem, (c) n 3 : Met, (d) n 4 : Mem. The second "challenge treatment" was given after a six day wash-out period on Day 21: (a) n 1 : Met, (b) n 2 : Met + Mem, (c) n 3 : Met, (d) n 4 : Mem. Changes in locomotion were measured for a period of 3 min in the Open field on Days 1, 7, 14 and 21 to assess the sensitising phenomenon. Met pre-treatment significantly sensitised to the effects of the challenge doses (n 1 ). Mem given alone did not change the measured behavioural parameters after the acute dose but it significantly decreased locomotion after its repeated administration (n 4 ). Repeated pre-treatment with the Met + Mem combination (n 3 ) did not produce sensitisation after Met challenge doses and similarly, repeated pretreatment with Met did not induce sensitisation after the challenge dose of Met + Mem (n 2 ). Thus, our results suggest that the role of the NMDA receptor antagonist memantine in the development and expression of behavioural sensitisation to Met seems to be an inhibitory one.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

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confidence: 99%

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The effect of memantine on behavioural sensitisation to methamphetamine in mice

Landa¹,

Šlais²,

Šulcová³

2012

Vet. Med. - Czech

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The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Landa¹,

Šlais²,

Máchalová³

et al. 2014

Vet. Med. - Czech

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ABSTRACT:The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to produce an increased behavioural response after its repeated application (behavioural sensitisation). It has also been described that an increased response to a drug may be elicited by previous repeated administration of another drug (cross-sensitisation). We have previously shown that the CB 1 , CB 2 and TRPV (vanilloid) cannabinoid receptor agonist methanandamide, cross-sensitised to Met stimulatory effects in mice. The present study was focused on ability of the more selective and potent CB 1 receptor activator arachidonylcyclopropylamide (ACPA) to elicit cross-sensitisation to the stimulatory effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into three groups and on seven occasions (from the 7 th to 13 th day of the experiment) were administered drugs as follows:(a) n 1 : vehicle at the dose of 10 ml/kg/day; (b) n 2 : Met at the dose of 2.5 mg/kg/day; (c) n 3 : ACPA at the dose of 1.0 mg/kg/day. Locomotor behaviour in the Open field test was measured (a) after administration of vehicle on the 1 st experimental day, (b) after the 1 st dose of drugs given on the 7 th day, and (c) on the 14 th day after the "challenge doses" administered in the following manner: n 1 : saline at a dose of 10 ml/kg, n 2, 3 : Met at a dose of 2.5 mg/kg. The observed behavioural changes consisted in: (a) gradual development of habituation to the open field conditions in three consecutive tests; (b) development of behavioural sensitisation to the stimulatory effects of Met after repeated treatment; (c) insignificant effect of repeated pre-treatment with ACPA on the stimulatory effects of Met challenge dose. The results of our study give rise to the question which of the cannabinoid receptor mechanisms might be most responsible for the neuroplastic changes inducing sensitisation to the stimulatory effects of Met. Keywords

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Apple and Pear Juices as Memory Boosters: Phytochemicals Analysis and Comparative Study between Natural Fruit Juices and Memantine

Gul,

Badar,

Leghari

et al. 2023

Bangladesh J Med Sci

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Background: Our memory is a treasure, a recollection of various events from our entire life. But a number of factors like aging, stress, anxiety, depression, injury, certain disorders or use of some medications may decrease the efficacy of our brain thereby affecting our memory. Objectives: The intend of our study was to evaluate the effect of a well renowned memory enhancing drug memantine on memory with fruits like apple (Malusdomestica) which is speculated to be good for memory. Methods: This study also aimed to put forward the positive effects of pear (Pyruscommunis L.) juice on memory. While 2nd part of study included qualitative and quantitative phytochemical screenings of apple and pear with peels and without peels. For first part of study, in vivo testing has been done onto 4 groups, i.e. control group, reference group, test group A &test group B. Mice’s behavior was evaluated using two apparatus i.e. Elevated Plus Maze for 3 days & Novel Object Recognition Chamber for 2 days. While phytochemical analysis has been performed on the pericarp and mesocarp region of fresh fruits which were isolated, shade dried, blended and finely powdered. Result: Results prove that pear juice does impart positive effects on memory and can prove to be an alternative in the prevention of memory loss. Both tested fruits (apple& pear in juice/ liquid form), do pose remarkably positive effects on brain’s activity. Apple juice has shown more memory enhancing effects and was closer to that of our standard drug i.e. memantine. It can be concluded that apple and pear both contain flavonoids like quercetin and epicatechin, having antioxidant properties, which can help reverting or preventing the age-related oxidative degeneration of neurons. Conclusion: Although the memory enhancing effects of reference standard i.e. memantine is high as compare to our tested fruit juices but still it gives hope and evidenced that apple and pear juices can serve as memory enhancers to save our memory from deteriorating and active constituents from apples and pears could consider as excellent source for drug development and future pharmacological studies. Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 842-849

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The effect of sertindole on behavioural sensitisation to methamphetamine in mice

Cited by 3 publications

References 30 publications

The effect of memantine on behavioural sensitisation to methamphetamine in mice

The effect of memantine on behavioural sensitisation to methamphetamine in mice

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Apple and Pear Juices as Memory Boosters: Phytochemicals Analysis and Comparative Study between Natural Fruit Juices and Memantine

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