The effect of Sertraline, Paroxetine, Fluoxetine and Escitalopram on testicular tissue and oxidative stress parameters in rats

Abstract

These data suggest that SSRIs have a negative effect on testicular tissues. This negative impact is markedly greater in the paroxetine group. To determine the exact mechanism of action of these drugs on testicular tissue, well-designed randomized controlled clinical studies are needed on a larger population.

Warfarin‐induced vitamin K deficiency affects spermatogenesis in Sprague‐Dawley rats

“…The seminiferous tubules were scored using a modified method described by Erdemir et al (2014). The seminiferous tubules were scored using a modified method described by Erdemir et al (2014).…”

“…The average score of 50 tubules was used to determine the spermatogenic activities (Erdemir et al, 2014). The variations in the germ cell types at different stages of the seminiferous tubules were considered.…”

“…histomorphometric and histomorphological features that was evaluated includes: the diameter of the seminiferous tubules and its lumen, the seminiferous luminal content , the arrangement of germ cells within the seminiferous epithelium, the presence of Leydig cells and its features, presence of other abnormalities associated with disturbed spermatogenesis while the histomorphology of the epididymal epithelium, the density of the epididymal luminal content were also observed. The seminiferous tubules were scored using a modified method described by Erdemir et al (2014).…”

Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia

“…Oxidative stress is associated with an increased rate of cellular damage induced by oxygen and oxygen-derived oxidants, commonly known as reactive oxygen species [35, 36]. The major targets of reactive oxygen species are membrane lipids, in a process known as lipid peroxidation.…”

“…It is also admitted that testicular tissues and spermatozoa are very sensitive to reactive oxygen species attack and lipid peroxidation. The susceptibility of testicular tissues to oxidation is attributed to the high polyunsaturated fatty acid content of sperm membranes [36, 37]. Many tissues contain powerful endogenous scavengers that provide protection against free radical damage, including SOD, CAT, glutathione peroxidase, ascorbic acid, and α -tocopherol [38].…”