The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction

Keskin, Muhammed; Kaya, Adnan; Tatlısu, Mustafa Adem; Hayıroğlu, Mert İlker; Uzman, Osman; Börklü, Edibe Betül; Çinier, Göksel; Çakıllı, Yasin; Yaylak, Barış; Eren, Mehmet

doi:10.1016/j.ijcard.2016.07.024

Cited by 22 publications

(37 citation statements)

References 14 publications

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“…9,15,16 In the study by Choi et al 10 and Ma et al 19 patients with a SPC of 3.5 to less than 4.0 mEq/L and patients with a SPC of 4.0 to less than 4.5 mEq/L had a similar risk of dying. In contrast, Keskin et al 28 found a slightly higher inhospital mortality (3.7%) in patients with a SPC of 3.5 to less than 4.0 mEq/L than in patients with a SPC of 4.0 to less than 4.5 mEq/L (3.1%). Six studies were included in the meta-analysis.…”

Section: Short-term Mortalitymentioning

confidence: 80%

“…In two studies, adjusted odds ratios (ORs) were used as effect sizes, 9,16 whereas Ma et al 19 and Patel et al 15 provided hazard ratios (HRs). Choi et al 10 reported an unadjusted number of events and Keskin et al 28 used a different reference category than required. In order to include all studies in the meta-analysis, the unadjusted number of deaths from the studies of Keskin et al, 28 Ma et al 19 and Patel et al 15 was used in the analysis.…”

Section: Short-term Mortalitymentioning

confidence: 99%

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Association of serum potassium concentration with mortality and ventricular arrhythmias in patients with acute myocardial infarction: A systematic review and meta-analysis

Colombo

Kirchberger

Amann

et al. 2018

Eur J Prev Cardiolog

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Background Challenging clinical practice guidelines that recommend serum potassium concentration between 4.0-5.0 mEq/L or ≥4.5 mEq/L in patients with acute myocardial infarction, recent studies found increased mortality risks in patients with a serum potassium concentration of ≥4.5 mEq/L. Studies investigating consequences of hypokalemia after acute myocardial infarction revealed conflicting results. Therefore, the aim of this systematic review and meta-analysis was to combine evidence from previous studies on the association of serum potassium concentration with both short and long-term mortality as well as the occurrence of ventricular arrhythmias. Design Systematic review and meta-analysis. Methods A structured search of MEDLINE and EMBASE databases yielded 23 articles published between 1990 and January 2017 that met the inclusion criteria. Study selection, data extraction and quality assessment were carried out by three reviewers. Random effects models were used to pool estimates across the included studies and sensitivity analyses were performed when possible. Results Twelve studies were included in the meta-analysis. Both pooled results from six studies investigating short-term mortality and from five studies examining long-term mortality revealed significantly increased risks in patients with serum potassium concentrations of <3.5 mEq/L, 4.5-<5.0 mEq/L and ≥5.0 mEq/L after acute myocardial infarction. In addition, a serum potassium concentration of <3.5 mEq/L was significantly associated with the occurrence of ventricular arrhythmias. Conclusions Mortality, both short and long term, and the occurrence of ventricular arrhythmias in patients with acute myocardial infarction seem to be negatively associated with hypokalemic serum potassium concentration. There is evidence for adverse consequences of serum potassium concentrations of ≥4.5 mEq/L. Due to the heterogeneity among existing studies, further research is necessary to confirm the need to change clinical practice guidelines.

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Section: Short-term Mortalitymentioning

confidence: 80%

Section: Short-term Mortalitymentioning

confidence: 99%

Association of serum potassium concentration with mortality and ventricular arrhythmias in patients with acute myocardial infarction: A systematic review and meta-analysis

Colombo

Kirchberger

Amann

et al. 2018

Eur J Prev Cardiolog

View full text Add to dashboard Cite

show abstract

“…Even though electrolytes have a significant role in maintaining the integrity of the cardiovascular system, their role in the diagnosis and prognosis of ACS has not been given considerable significance, albeit a few researches on this topic show the relationship of serum levels of sodium (Na) and potassium (K) with long term mortality risk in ACS patients 8, 9, 10, 11. Magnesium (Mg) serves as a beta-adrenoreceptor blocker and also has an anti-platelet action 11 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of serum blood urea nitrogen, creatinine and electrolytes in the diagnosis and mortality risk assessment of patients with acute coronary syndrome

Adam

Nasir

Merchant

et al. 2018

Indian Heart Journal

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“…3 Similarly, Keskin et al showed the association of mean serum K levels with in-hospital mortality, ventricular arrhythmias, and long-term mortality after STEMI. 4 The former study shows the importance of early intervention to restore serum K levels to normal limits and to perform more frequent serum K measurements according to admission serum K levels. The latter study draws attention to mean serum K levels derived from all K measurements during hospitalization.…”

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confidence: 97%

More About the Effect of Dynamic Potassium Change in STEMI

Kaya

Keskin²,

Tatlısu

et al. 2018

Angiology

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The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction

Cited by 22 publications

References 14 publications

Association of serum potassium concentration with mortality and ventricular arrhythmias in patients with acute myocardial infarction: A systematic review and meta-analysis

Association of serum potassium concentration with mortality and ventricular arrhythmias in patients with acute myocardial infarction: A systematic review and meta-analysis

Efficacy of serum blood urea nitrogen, creatinine and electrolytes in the diagnosis and mortality risk assessment of patients with acute coronary syndrome

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