The effect of sevoflurane on the release of [3H]dopamine from rat brain cortical slices

Silva, Janice H.; Gomez, Renato Santiago; Diniz, Paulo Henrique Costa; Gomez, Marcus V.; Guatimosim, Cristina

doi:10.1016/j.brainresbull.2007.01.011

Cited by 14 publications

(7 citation statements)

References 34 publications

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“…Research on these proteins has revealed that γ‐aminobutyric acid type A (GABA A ) receptors are likely involved in the molecular actions of sevoflurane (11–17). It may also act by inhibiting excitatory ion channels such as neuronal nicotinic and glutamate receptors (12, 18–22). The action of a volatile agent on neurotransmitter receptors is dominant, while it also affects the release of neurotransmitters.…”

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confidence: 99%

Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects

Qiu

Ramani

Swetye

et al. 2008

Magnetic Resonance in Med

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Functional MR imaging was performed in sixteen healthy human subjects measuring both regional cerebral blood flow (CBF) and blood oxygen level dependent (BOLD) signal when visual and auditory stimuli were presented to subjects in the presence or absence of anesthesia. During anesthesia, 0.25 mean alveolar concentration (MAC) sevoflurane was administrated. We found that low-dose sevoflurane decreased the taskinduced changes in both BOLD and CBF. Within the visual and auditory regions of interest inspected, both baseline CBF and the task-induced changes in CBF decreased significantly during anesthesia. Low-dose sevoflurane significantly altered the task-induced CBF-BOLD coupling; for a unit change of CBF, a larger change in BOLD was observed in the anesthesia condition than in the anesthesia-free condition. Low-dose sevoflurane was also found to have significant impact on the spatial nonuniformity of the task-induced coupling.

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confidence: 99%

Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects

Qiu

Ramani

Swetye

et al. 2008

Magnetic Resonance in Med

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“…9 Regarding the presynaptic effects of these anesthetics, isoflurane and halothane increase basal dopamine release in the rat striatum. 26 In addition, although Silva and colleagues 27 have shown that sevoflurane (0.46 mM) increases significantly the release of dopamine, it was by a nonvesicular process independent of synaptic vesicle exocytosis. Moreover, Shichino et al 28 showed that volatile anesthetics such as sevoflurane and isoflurane suppressed ACh release in a dose-dependent manner in nonstimulated rat cerebral cortex.…”

Section: Discussionmentioning

confidence: 97%

Comparative presynaptic effects of the volatile anesthetics sevoflurane and isoflurane at the mouse neuromuscular junction

et al. 2015

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“…Sevoflurane also has many biochemical actions, and it has been shown to inhibit the function of the nicotinic acetylcholine receptor in the postsynaptic membrane and significantly reduce the transmission of acetylcholine between synapses ( 55 ). Nishikawa et al found that sevoflurane enhanced GABAA receptor-mediated synaptic inhibition in hippocampal interneurons ( 56 ), and Silva JH et al found that sevoflurane increased the levels of extracellular [3H] dopamine in rat brain cortical slices ( 57 ). The effects of propofol and sevoflurane on neurotransmitters in the central nervous system are related to the neural mechanism of the attention network, which can reduce the efficiency of the attention network.…”

Section: Discussionmentioning

confidence: 99%

Propofol Versus Sevoflurane General Anaesthesia for Selective Impairment of Attention Networks After Gynaecological Surgery in Middle-Aged Women: A Randomised Controlled Trial

et al. 2022

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PurposeAttention is an essential component of cognitive function that may be impaired after surgery with anaesthesia. Propofol intravenous anaesthesia and sevoflurane inhalational anaesthesia are frequently used in gynaecological surgery. However, which type of anaesthetic has fewer cognitive effects postoperatively remains unclear. We compared the differences in attention network impairment after surgery in women receiving propofol versus sevoflurane general anaesthesia.Patients and MethodsEighty-three patients with gynaecological diseases who were 40–60 years of age were involved in the study. All patients underwent elective gynaecological surgery under either total intravenous anaesthesia or sevoflurane inhalational anaesthesia, depending on randomisation. The efficiencies of the three attention networks were captured using the attention network test preoperatively and on the 1st and 5th postoperative days.ResultsBoth groups of patients showed differences in impairments on the 1st and 5th postoperative days. Pairwise comparisons indicated that the alerting and orienting networks of patients in the propofol group were impaired to a greater extent than those of patients in the sevoflurane group on the 1st postoperative day, while the executive control network was impaired to a lesser extent. On the 5th postoperative day, the alerting networks of both groups recovered to the baseline level. Patients in the propofol group still showed impairment of the orienting network, while patients in the sevoflurane group recovered to baseline. For the executive control network, patients in the sevoflurane group still exhibited more severe impairment than those in the propofol group.ConclusionIn middle-aged women, propofol impaired orienting and alerting networks more than sevoflurane, while sevoflurane showed more residual impairment of the executive control network.

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The effect of sevoflurane on the release of [3H]dopamine from rat brain cortical slices

Cited by 14 publications

References 34 publications

Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects

Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects

Comparative presynaptic effects of the volatile anesthetics sevoflurane and isoflurane at the mouse neuromuscular junction

Propofol Versus Sevoflurane General Anaesthesia for Selective Impairment of Attention Networks After Gynaecological Surgery in Middle-Aged Women: A Randomised Controlled Trial

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