The effect of sex and age on caffeine pharmacokinetics in cattle

Janus, K; Antoszek, J.

doi:10.1053/rvsc.2000.0381

Cited by 13 publications

(6 citation statements)

References 38 publications

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“…The high inhibition observed in our study could be indicating that a chlorpyrifosoxon was produced since phosphorothionates like chlorpyrifos do not directly inhibit AChE, but must first be metabolized to the corresponding oxygen analog (chlorpyrifosoxon) (Timchalk et al 2002). In cattle and other domestic animals, possible gender-effects on pharmacokinetics, including P450 drug metabolism, have already been described (Capece et al 2000;Janus and Antoszek 2000). Specifically, the male piedmontese cattle showed significantly higher CYP3A-dependent drug metabolizing enzymes activities compared to the females ones (Dacasto et al 2005).…”

Section: Discussionmentioning

confidence: 60%

Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration

et al. 2008

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The aim of this work was to study the pharmacokinetic behaviour and the inhibitory effect on acetylcholinesterase and butyrylcholinesterase activities of chlorpyrifos in male and female cattle after pour-on administration. Determination of cholinesterase activity in plasma and erythrocyte was carried out according to Ellman kinetic method. The mean baseline activities were 9338.39 +/- 1331.61 and 13220.69 +/- 2274.18 to acetylcholinesterase and 624.65 +/- 39.32 and 641.68 +/- 88.08 IU/L to butyrylcholinesterase in females and males, respectively. Acetylcholinesterase was the predominant form of cholinesterase analyzed, with low levels of butyrylcholinesterase. The basal acetylcholinesterase activities of the bulls were significantly greater than those of cows. The inhibitory effect of topical chlorpyrifos administration was lower on butyrylcholinesterase than on acetylcholinesterase. Chlorpyrifos peak plasma concentration (male:10.920 +/- 4.18; female:12.12 +/- 3.88 microg/L) were reached at 11.92 +/- 9.19 and 8.17 +/- 7.67 h in male and female, respectively. The values of area under curve were 185.96 +/- 168.45 and 278.89 +/- 270.00 microg h/L and mean residence time were 13.95 +/- 8.10 and 14.90 +/- 9.80 h in male and female, respectively.

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Section: Discussionmentioning

confidence: 60%

Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration

et al. 2008

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“…Results also revealed that the pharmacokinetic properties of caffeine in alpacas and llamas were similar to disposition of the drug in other species. [7][8][9][10][11][12][13] Values for total plasma caffeine clearance, elimination half-life, and mean residence time in adult alpacas and llamas were similar to those reported for horses, 7,18 donkeys, 18 sheep, 13 cattle, 9,13 and dogs. 10 Values for volumes of distribution were similar to those reported for horses, 7,18 donkeys, 18 sheep, 13 cattle, 9,11 dogs, 10 and camels.…”

Section: Discussionmentioning

confidence: 58%

“…Caffeine clearance is a useful measure of hepatic function because caffeine has low toxicity, is simple to measure, and has an elimination half-life that is highly correlated with hepatic function. [7][8][9][10][11][12][13] The purpose of the study reported here was to determine total plasma clearance and elimination half-life of caffeine in clinically normal alpacas and llamas.…”

mentioning

confidence: 99%

Pharmacokinetics of intravenously administered caffeine in healthy alpacas (Lama pacos) and llamas (Lama glama)

Lakritz¹,

Middleton²,

Anderson³

et al. 2006

ajvr

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High-performance liquid chromatography and liquid chromatography-mass spectrometry were suitable methods for determination of plasma caffeine concentrations in alpacas and llamas. Plasma caffeine concentration-time curves were best described by a 2-compartment model. Elimination half-lives, plasma clearance, volume of distribution at steady state, and mean residence time were not significantly different between alpacas and llamas. Intravenous administration of caffeine at a dose of 3 mg/kg did not induce clinical signs of excitement.

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“…The effect of gender on the pharmacokinetics of caffeine (5 mg/kg, intravenously) was explored in 10 male and 10 female Holstein cattle during the ages 1, 2, 4, 6, 8, 12, and 18 months (Janus and Antoszek, 2000). The findings were compared to the results in other species, including humans.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Evaluation of the reproductive and developmental risks of caffeine

Brent

Christian

Diener

2011

Birth Defects Research Pt B

120

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A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction. These effects are of interest to teratologists, because animal studies are useful in their evaluation. Many of the epidemiology studies did not evaluate the impact of the “pregnancy signal,” which identifies healthy pregnancies and permits investigators to identify subjects with low pregnancy risks. The spontaneous abortion epidemiology studies were inconsistent and the majority did not consider the confounding introduced by not considering the pregnancy signal. The animal studies do not support the concept that caffeine is an abortafacient for the wide range of human caffeine exposures. Almost all the congenital malformation epidemiology studies were negative. Animal pharmacokinetic studies indicate that the teratogenic plasma level of caffeine has to reach or exceed 60 µg/ml, which is not attainable from ingesting large amounts of caffeine in foods and beverages. No epidemiological study described the “caffeine teratogenic syndrome.” Six of the 17 recent epidemiology studies dealing with the risk of caffeine and fetal weight reduction were negative. Seven of the positive studies had growth reductions that were clinically insignificant and none of the studies cited the animal literature. Analysis of caffeine's reproductive toxicity considers reproducibility and plausibility of clinical, epidemiological, and animal data. Moderate or even high amounts of beverages and foods containing caffeine do not increase the risks of congenital malformations, miscarriage or growth retardation. Pharmacokinetic studies markedly improve the ability to perform the risk analyses. Birth Defects Res (Part B) 92:152–187, 2011. © 2011 Wiley-Liss, Inc.

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The effect of sex and age on caffeine pharmacokinetics in cattle

Cited by 13 publications

References 38 publications

Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration

Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration

Pharmacokinetics of intravenously administered caffeine in healthy alpacas (Lama pacos) and llamas (Lama glama)

Evaluation of the reproductive and developmental risks of caffeine

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