The effect of sex hormones on bone metabolism of the otic capsule – an overview

Horner, Kathleen C.

doi:10.1016/j.heares.2008.12.004

Cited by 55 publications

(49 citation statements)

References 84 publications

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“…A large number of candidate genes have been identified in one study or another as being associated with osteoporosis. Most genetic studies in osteoporosis to date have focused on the genes of transforming growth factor and growth factors known to be involved in bone turnover (Bertoldo et al, 2000;Ben Amor et al, 2012), bone component gene (Weichetova et al, 2000), and hormones and their receptors that are related to bone metabolism (Horner, 2009;Horwitz et al, 2010). Among these candidate genes, VDR and ESR1 have received more attention (Kung et al, 1998), which was also the case in our study when comparing the mRNA expression of blood B cells from different bone mineral density samples.…”

Section: Discussionsupporting

confidence: 59%

Screening and functional microarray analysis of differentially expressed genes related to osteoporosis

Chen¹,

Xia²

2014

Genet. Mol. Res.

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ABSTRACT. We searched for key genes that could accurately predict bone mineral density. The gene expression profile GSE7429 was downloaded from the Gene Expression Omnibus database, which includes 20 samples, 10 with high and 10 with low bone mineral density. The differentially expressed genes (DEGs) were identified with packages in R language. Further, BLASTX was used to obtain COG function classifications of all the DEGs. The GOTM software was used to find DEGs enriched modules. The functions of genes in the modules was also predicted with the software GENECODIS. Three hundred and three genes were identified as DEGs by comparing high and low bone mineral density samples; the selected genes were mapped to 14 modules collected in PPID. Genes VDR, ESR1, and NRIP1, located in the same module, were significantly enriched in intracellular receptor-mediated signaling biological processes. We conclude that the genes VDR, ESR1, NRIP1 in B cells have a close relationship with bone mineral density. The expression patterns of these genes could be used to determine osteoprotegerin function and for early diagnosis and prevention of low bone mineral density.

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Section: Discussionsupporting

confidence: 59%

Screening and functional microarray analysis of differentially expressed genes related to osteoporosis

Chen¹,

Xia²

2014

Genet. Mol. Res.

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“…We conjecture that our finding of the increasing prevalence of SSCD with age may be related to systemic bony demineralization generally observed to increase with age. However, while bone resorption in the inner ear in the setting of osteoporosis has been shown in animal models, 7 to our knowledge, it has not been confirmed in human studies. Certainly, the utility of CT bone attenuation measurement in the diagnosis of otosclerosis has been investigated, with some but not all groups showing focal diminished bone attenuation in patients with otosclerosis compared with controls.…”

Section: Figmentioning

confidence: 69%

Superior Semicircular Canal Dehiscence: Congenital or Acquired Condition?

Nadgir¹,

Ozonoff²,

Devaiah³

et al. 2011

AJNR Am J Neuroradiol

102

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“…Otosclerosis is an inXammatory bone remodeling disorder of complex etiology causing progressive conductive and/or sensorineural hearing loss [1][2][3]. Among Caucasian white adults, the prevalence of otosclerosis is 0.3-0.4% of the general population, 5-7% of those with hearing loss and 18-25% of those with conductive hearing loss [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…OPG acts as a decoy receptor; it binds to RANKL (receptor activator of nuclear factor kappa b ligand) and blocks its interaction with RANK (receptor activator of nuclear factor kappa b), thus inhibiting osteoclast development and activation [17,18]. Several hormones and proinXammatory cytokines, including vitamin-D3, parathyroid hormone, TNF-alpha and IL-1, appear to stimulate osteoclast formation through the dual action of inhibiting production of OPG and stimulating production of RANKL [1,14,15,17,18]. Normally, human otic capsule is characterized by a high OPG expression, since bone turnover is almost completely absent within the bone adjacent to the perilymphatic space [20].…”

Section: Introductionmentioning

confidence: 99%

Osteoprotegerin expression and sensitivity in otosclerosis with different histological activity

Karosi

Csomor

Szalmás

et al. 2010

Eur Arch Otorhinolaryngol

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Otosclerosis is a complex bone dystrophy of the human otic capsule leading to conductive and sensorineural hearing loss. Since otosclerosis may, at least in part, be considered as an autoimmune-inflammatory disease, disturbed balance of TNF-alpha and osteoprotegerin (OPG) expression has been implicated in the pathological bone remodeling. It has been supposed that active otosclerosis is characterized by decreased or missing local OPG production with invariable OPG sensitivity of the otosclerotic foci. Ankylotic stapes footplates (n = 41) removed by stapedectomy were processed to histological examination, OPG-specific RT-PCR, tissue culturing and alkaline-phosphatase (AP) activity assessment, respectively. OPG concentration of serum specimens (n = 41) was measured by ELISA. Cortical bone fragments harvested from the external ear canal were used as negative controls of otosclerosis. Among 41 ankylotic stapes footplates, 22 active and 19 inactive otosclerosis cases were histologically diagnosed. OPG expression was significantly lower (p < 0.001) in active otosclerosis compared to inactive cases. Osteoclast cultures originated from active otosclerotic foci showed a considerable susceptibility against external OPG dosage, which resulted in a significant decrease of AP activity (p < 0.001). In contrast, OPG serum levels were in the normal range (5-100 ng/ml) indicating a non-systemic bone resorption. In conclusion, secondary decreased local OPG production might play an important role in the pathogenesis of otosclerotic bone remodeling disorder. As to previous and current results, decreased OPG sensitivity of lesion-forming cells should be excluded. These observations may indicate the potential role of recombinant OPG treatment in early stages of otosclerosis.

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The effect of sex hormones on bone metabolism of the otic capsule – an overview

Cited by 55 publications

References 84 publications

Screening and functional microarray analysis of differentially expressed genes related to osteoporosis

Screening and functional microarray analysis of differentially expressed genes related to osteoporosis

Superior Semicircular Canal Dehiscence: Congenital or Acquired Condition?

Osteoprotegerin expression and sensitivity in otosclerosis with different histological activity

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