The effect of shear and extensional viscosity on atomization in medical inhaler

Broniarz-Press, L.; Ochowiak, Marek; Matuszak, Magdalena; Włodarczak, Sylwia

doi:10.1016/j.ijpharm.2014.04.032

Cited by 15 publications

(3 citation statements)

References 25 publications

(29 reference statements)

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“…Viscosity effects are clearer, with jet nebulization being more efficient in terms of respirable output with liquids of low viscosity (1–6 cP). Thereafter and up to ceasing nebulization, increased viscosity increases MMAD as well as aerosol output, also in a device‐specific manner …”

Section: Established Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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Objectives In this review paper, we explore the interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations for several types of devices, namely jet, ultrasonic and vibrating-mesh nebulizers; colliding and extruded jets; electrohydrodynamic mechanism; surface acoustic wave microfluidic atomization; and capillary aerosol generation. Key findings Nebulization is the transformation of bulk liquids into droplets. For inhalation therapy, nebulizers are widely used to aerosolize aqueous systems, such as solutions and suspensions. The interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations plays a significant role in the performance of aerosol generation appropriate for pulmonary delivery. Certain types of nebulizers have consistently presented temperature increase during the nebulization event. Therefore, careful consideration should be given when evaluating thermo-labile drugs, such as protein therapeutics. We also present the general approaches for characterization of nebulizer formulations. Summary In conclusion, the interplay between the dosage form (i.e. aqueous systems) and the specific type of device for aerosol generation determines the effectiveness of drug delivery in nebulization therapies, thus requiring extensive understanding and characterization.

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Section: Established Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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“…Then the plate was placed under a Nikon Eclipse 50i microscope equipped with an OptaTech camera and a series of photos were taken using the MultiScanBase program from Computer Scanning Systems II. The methodology is described in detail in [19]. Figure 8 shows sample photos from the analysis obtained while spraying the liquid at a distance of 1 m from the measuring point for the F1 and F2 filters.…”

Section: Resultsmentioning

confidence: 99%

Analysis of the Possibility of Disinfecting Surfaces Using Portable Foggers in the Era of the SARS-CoV-2 Epidemic

et al. 2021

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The SARS-CoV-2 pandemic has resulted in the need for increased surface disinfection. For this purpose, biocides, UV-C radiation, or ozonation can be used. The most commonly used are biocides that can be deposited on the surface with the use of various devices, including foggers. The disinfection efficiency is related to the size of the aerosol droplets formed and their distribution. This paper specifies the distribution of droplet diameters and mean droplet diameters obtained during the use of a commercial fogger. It was shown that the droplet diameters formed were mainly in the range of up to 30–40 μm. A ceramic filter allowed for a larger number of smaller droplets and a limitation in the number of droplets with larger diameters. The results are important in the context of fighting the virus in hard-to-reach places where battery devices can be used.

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“…Viscosity also has a major impact in atomization. A study presented in [60] showed that the increase in shear and extensional viscosity increases droplet size. Especially, extension viscosity has a key role in the process.…”

Section: Continuity Equationmentioning

confidence: 99%

Nebulization Criteria and Quantification

Hailu

Postema

Krejcar

et al. 2020

Fluids

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The application of atomization technology is common in fields such as agriculture, cosmetics, environmental sciences, and medicine. Aerosolized drugs are administered using nebulizers to treat both pulmonary and nonpulmonary diseases. The characterization and measurement of nebulizers are of great significance in analyzing the performance and accuracy of the nebulizing system and the advancement of the technology. Nevertheless, the characterization of aerosols has been a long-standing challenge in scientific disciplines ranging from atmospheric physics to health sciences. The study of factors that influence nebulization has not been undertaken systematically using experimental techniques. Numerical modeling (NM) and computational fluid dynamics (CFD) can address such issues. This article provides a concise overview of the literature on the application of computational fluid dynamics to medical nebulizers and aerosol measurements.

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The effect of shear and extensional viscosity on atomization in medical inhaler

Cited by 15 publications

References 25 publications

The function and performance of aqueous aerosol devices for inhalation therapy

The function and performance of aqueous aerosol devices for inhalation therapy

Analysis of the Possibility of Disinfecting Surfaces Using Portable Foggers in the Era of the SARS-CoV-2 Epidemic

Nebulization Criteria and Quantification

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