The effect of shear flow on microreactor clogging

Sicignano, Luca; Tomaiuolo, Giovanna; Perazzo, Antonio; Nolan, Steven P.; Maffettone, Pier Luca; Guido, Stefano

doi:10.1016/j.cej.2018.02.037

Cited by 32 publications

(20 citation statements)

References 45 publications

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“…Coating (for example by poly-l-lysine) to obtain stable nonpyrogenic MNP suspension [115] product homogeneity quality reduction by concentration gradients and hot spots in the reaction flask [25,51] enhanced quality due to homogeneous morphology, narrow size distribution [25,67,116] high within one bacteria strain but strain variation possible [52][53][54]95] reproducibility, production rate and scale-up capability significant batch to batch variations in size, morphology, and magnetic properties [25,111,[117][118][119], poor scaling up capability. A reported study from Lin et al showed a production rate of 4.73 g/h for microfluidic synthesis comparing to 1.4 g/h for conventional synthesis with the same conditions [89] continuous production, no batch-to-batch variation, high scale-up capability high at the defined environmental conditions [92], mg/(L • day) production rate [52], high scale-up capability, though challenging due to long term bacteriostatic growth conditions [38,40,46,78] clogging not applicable microchannel-wall blocking during nucleation or by agglomeration [77,104,[120][121][122] not applicable automation poor feasible/integratable [66,123,124] capability of online characterization not applicable for batch, though magnetic characterization of whole batches by magnetic particle spectroscopy is feasible parameter control and synthesis adjustment feasible during synthesis, control of magnetic parameters by magnetic particle spectroscopy [25,125] and NMR [126] cost low, common lab equipment expensive microreactor fabrication expensive specialized equipment…”

Section: Comparison Of Different Synthesesmentioning

confidence: 99%

Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

2021

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Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable of controlling and adjusting structure, size, shape and magnetic properties are mandatory. In this review, we discuss advanced methods for engineering and utilizing MNPs, such as continuous synthesis approaches using microtechnologies and the biosynthesis of magnetosomes, biotechnological synthesized iron oxide nanoparticles from bacteria. We compare the technologies and resulting MNPs with conventional synthetic routes. Prominent biomedical applications of the MNPs such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery and magnetic actuation in micro/nanorobots will be presented.

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Section: Comparison Of Different Synthesesmentioning

confidence: 99%

Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

2021

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“…The final image is produced by the consecutive magnifications of the objective lenses (placed near the specimen) and the ocular and can be viewed directly or captured via a digital camera (e.g., digital video microscopy) [ 144 ]. Especially for fouling investigations, high-speed cameras constitute an essential tool to monitor the phenomena happening at very short times, such as foulants deposition and pore clogging [ 145 , 146 ].…”

Section: Dynamic Investigation Techniquesmentioning

confidence: 99%

Membrane Fouling Phenomena in Microfluidic Systems: From Technical Challenges to Scientific Opportunities

2021

Self Cite

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The almost ubiquitous, though undesired, deposition and accumulation of suspended/dissolved matter on solid surfaces, known as fouling, represents a crucial issue strongly affecting the efficiency and sustainability of micro-scale reactors. Fouling becomes even more detrimental for all the applications that require the use of membrane separation units. As a matter of fact, membrane technology is a key route towards process intensification, having the potential to replace conventional separation procedures, with significant energy savings and reduced environmental impact, in a broad range of applications, from water purification to food and pharmaceutical industries. Despite all the research efforts so far, fouling still represents an unsolved problem. The complex interplay of physical and chemical mechanisms governing its evolution is indeed yet to be fully unraveled and the role played by foulants’ properties or operating conditions is an area of active research where microfluidics can play a fundamental role. The aim of this review is to explore fouling through microfluidic systems, assessing the fundamental interactions involved and how microfluidics enables the comprehension of the mechanisms characterizing the process. The main mathematical models describing the fouling stages will also be reviewed and their limitations discussed. Finally, the principal dynamic investigation techniques in which microfluidics represents a key tool will be discussed, analyzing their employment to study fouling.

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“…They eventually cause local clustering of particles or the formation of particle arches. The deposition of particles was found to be the start of the clogging process, and these deposited particles could act as obstacles to further capture other suspended particles from the flow 23,24,25 . Thus, both the growth of deposited particle dendrites and the agglomeration of suspended particles could augment the clogging phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Mechanism for clogging of microchannels by small particles with liquid cohesion

Shao

Ruan

2021

AIChE Journal

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We numerically investigate the effect of liquid cohesion on the clogging of microchannels induced by small wet particles. The computer simulation is performed by the discrete element method (DEM) with cohesive contact models in presence of pendular liquid bridges, which is embedded into the computational fluid dynamics (CFD). We find that liquid cohesion significantly promotes particle deposition and agglomerate growth. A clogging phase diagram, in the form of Weber number and Stokes number, is constructed to quantify the clogging‐nonclogging transition. The competition between particle–particle and particle–fluid interactions is quantitatively discussed in terms of particle velocity and slip velocity. Strong cohesion can address a greater slip velocity or drag between particles and fluid, which depresses the resuspension of deposited particles and results in clogging. Finally, we compare our results with clogging induced by van der Waals adhesion of small dry particles and find that the competence of liquid cohesion is more prominent.

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The effect of shear flow on microreactor clogging

Cited by 32 publications

References 45 publications

Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

Membrane Fouling Phenomena in Microfluidic Systems: From Technical Challenges to Scientific Opportunities

Mechanism for clogging of microchannels by small particles with liquid cohesion

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