The Effect of Short-chain Fatty Acid Supplementation on Acute Colonic Inflammation in Rats Fed With Western Diet: Role of the Peroxisome Proliferator-activated Receptor-gamma
Abstract:Increased incidence of inflammatory bowel disease (IBD) is associated with the consumption of westernized diet (WD). In male Wistar albino rats induced with colitis by oral intake of dextran-sulfate sodium (DSS) for 10 days, we investigated how colitis-induced oxidative damage is affected by WD consumption started 3 weeks before DSS intake. Secondly, the putative protective effects of short-chain fatty acids (SCFAs) were evaluated in both WD-fed and normal diet (ND)-fed rats. WD consumption prior to colitis in… Show more
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