The Effect of Short-term Cold and Hot Exposure on Total Plasma Ghrelin Concentrations in Humans

Tomasik, Przemysław; Sztefko, Krystyna; Pizon, Monika

doi:10.1055/s-2005-861296

Cited by 31 publications

(42 citation statements)

References 10 publications

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“…This is concordant with the observed increase in EI, although the absence of a correlation between acylated ghrelin and the difference in EI between the two conditions weakens this link. Although total and acylated ghrelin concentrations were not affected by temperature (7, 20, and 33 °C) or exercise in a recent study [38], Tomasik et al [41] reported higher total ghrelin concentrations after exposure to 2 °C relative to 20 °C. The subsequent EI was not assessed in these studies, but ghrelin could play a role in the increase in EI following exposure to the cold.…”

Section: Effect Of Exercise Sessions Under Cool Conditionsmentioning

confidence: 99%

“…Plasma levels of total and/or acylated (its active form) ghrelin were not different after exercise in a hot environment that after the same exercises performed in a thermoneutral one [33,34,35,36,37]. Tomasik et al [41] reported that heat exposure (30 °C) only increased plasma ghrelin levels compared to the thermoneutral condition [41]. The study of Faure et al [35] consisted of two sedentary sessions in hot or neutral conditions (31 and 22 °C, respectively) that were comparable to the conditions of the study of Tomasik et al [41].…”

Section: Effect Of Exercise Sessions Under Hot Conditionsmentioning

confidence: 99%

“…Tomasik et al [41] reported that heat exposure (30 °C) only increased plasma ghrelin levels compared to the thermoneutral condition [41]. The study of Faure et al [35] consisted of two sedentary sessions in hot or neutral conditions (31 and 22 °C, respectively) that were comparable to the conditions of the study of Tomasik et al [41]. However, total ghrelin levels were unaffected.…”

Section: Effect Of Exercise Sessions Under Hot Conditionsmentioning

confidence: 99%

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Influence of Hot and Cold Environments on the Regulation of Energy Balance Following a Single Exercise Session: A Mini-Review

Charlot¹,

Faure

Antoine‐Jonville

2017

Nutrients

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Understanding the regulation of human food intake in response to an acute exercise session is of importance for interventions with athletes and soldiers, as well as overweight individuals. However, the influence of hot and cold environments on this crucial function for the regulation of body mass and motor performance has not been summarized. The purpose of this review was to exhaustively search the literature on the effect of ambient temperature during an exercise session on the subsequent subjective feeling of appetite, energy intake (EI) and its regulation. In the absence of stress due to environmental temperature, exercise-induced energy expenditure is not compensated by EI during an ad libitum meal following the session, probably due to decreased acylated ghrelin and increased peptide tyrosine tyrosine (PYY), glucagon-like peptide 1 (GLP-1), and pancreatic polypeptide (PP) levels. No systematic analysis has been yet made for major alterations of relative EI in cold and hot environments. However, observed eating behaviors are altered (proportion of solid/liquid food, carbohydrate/fat) and physiological regulation appears also to be altered. Anorexigenic signals, particularly PYY, appear to further increase in hot environments than in those that are thermoneutral. Ghrelin and leptin may be involved in the observed increase in EI after exercise in the cold, in parallel with increased energy expenditure. The potential influence of ambient thermal environment on eating behaviors after an exercise session should not be neglected.

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Section: Effect Of Exercise Sessions Under Cool Conditionsmentioning

confidence: 99%

Section: Effect Of Exercise Sessions Under Hot Conditionsmentioning

confidence: 99%

Section: Effect Of Exercise Sessions Under Hot Conditionsmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Hot and Cold Environments on the Regulation of Energy Balance Following a Single Exercise Session: A Mini-Review

Charlot¹,

Faure

Antoine‐Jonville

2017

Nutrients

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“…Likewise, in humans the Trier Social Stress Test consisting of an interview in front of three investigators and giving a speech which is videotaped, moderately increased plasma total ghrelin levels [93, 96]. In addition, a 30-min cold exposure in healthy 12-h fasted subjects induces a significant rise in plasma ghrelin levels [116]. …”

Section: Influence Of Various Stressors On Ghrelin Expressionmentioning

confidence: 99%

Stress-related alterations of acyl and desacyl ghrelin circulating levels: Mechanisms and functional implications

2011

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Ghrelin is the only known peripherally produced and centrally acting peptide hormone that stimulates food intake and digestive functions. Ghrelin circulates as acylated and desacylated forms and recently the acylating enzyme, ghrelin-O-acyltransferase (GOAT) and the de-acylating enzyme, thioesterase 1/lysophospholipase 1 have been identified adding new layers of complexity to the regulation of ghrelin. Stress is known to alter gastrointestinal motility and food intake and was recently shown to modify circulating ghrelin and GOAT levels with differential responses related to the type of stressors including a reduction induced by physical stressors (abdominal surgery and immunological/endotoxin injection, exercise) and elevation by metabolic (cold exposure, fasting and caloric restriction) and psychological stressors. However, the pathways underlying the alterations of ghrelin under these various stress conditions are still largely to be defined and may relate to stress-associated autonomic changes. There is evidence that alterations of circulating ghrelin may contribute to the neuroendocrine and behavioral responses along with sustaining the energetic requirement needed upon repeated exposure to stressors. A better understanding of these mechanisms will allow targeting components of ghrelin signaling that may improve food intake and gastric motility alterations induced by stress.

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“…36) Conflicting data are available regarding the effect of stress on ghrelin secretion. Acute psychosocial stress 37,38) or cold exposure 39) increased plasma ghrelin levels. However, there are several reports showing that plasma ghrelin levels did not change or even decreased with exposure to stresses.…”

Section: Human Studiesmentioning

confidence: 99%

Pathophysiologic Basis of Anorexia: Focus on the Interaction between Ghrelin Dynamics and the Serotonergic System

Takeda

Nakagawa

Okubo

et al. 2013

Biological & Pharmaceutical Bulletin

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Anorexia is an important issue in the management of elderly patients with cancer because it contributes to the development of malnutrition, increases morbidity and mortality, and negatively affects patients' quality of life. This review summarizes the potential mechanisms of the development of anorexia in three animal models that mimic the situations commonly seen in elderly patients receiving chemotherapy. Cisplatin-induced anorexia is attributable to a decrease in peripheral and central ghrelin secretion caused by the stimulation of serotonin (5-hydroxytryptamine; 5-HT)2B and 5-HT2C receptors via 5-HT secretion. Age-associated anorexia is caused by an increase in plasma leptin, which results from disturbed reactivity of ghrelin in the hypothalamus and regulation of ghrelin secretion. Environmental change causes the activation of central 5-HT1B and 5-HT2C receptors and the melanocortin-4 receptor system, resulting in a decrease in circulating ghrelin levels which lowers food intake. New therapeutic approaches based on these pathophysiological mechanisms are warranted for the treatment of anorexia in cancer patients, especially elderly ones.

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The Effect of Short-term Cold and Hot Exposure on Total Plasma Ghrelin Concentrations in Humans

Cited by 31 publications

References 10 publications

Influence of Hot and Cold Environments on the Regulation of Energy Balance Following a Single Exercise Session: A Mini-Review

Influence of Hot and Cold Environments on the Regulation of Energy Balance Following a Single Exercise Session: A Mini-Review

Stress-related alterations of acyl and desacyl ghrelin circulating levels: Mechanisms and functional implications

Pathophysiologic Basis of Anorexia: Focus on the Interaction between Ghrelin Dynamics and the Serotonergic System

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