The Effect of Short-Term Immobilization on the Rabbit Knee Joint Cartilage

Troyer, Henry

doi:10.1097/00003086-197503000-00029

Cited by 57 publications

(18 citation statements)

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“…IK cartilage was also consistently thinner than that from CK (Table 1) although, not unexpectedly, the thickness of CK cartilage varied widely from animal to animal. In other studies decreases in metachromasia (20) and hexosamine content (2 I ), also indicating GAG depletion, were among the earliest changes noted after immobilization. In the present study the diminution in Safranin-0 staining was accompanied by a decrease in tissue content of ' 3 PGs, which indicated a decrease in PG synthesis since the rate of PG degradation was unaffected.…”

Section: Discussionmentioning

confidence: 62%

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

Palmoski

Perricone

Brandt

1979

Arthritis & Rheumatism

283

131

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Healthy adult dogs were studied for a defect in proteoglycan aggregation by immobilizing one limb for varying periods of time. Immobilization for 6 days resulted in a 41% reduction in proteoglycan synthesis by articular cartilage from the restrained knee compared with the contralateral control knee. After 3 weeks of immobilization, proteoglycan aggregation was no longer demonstrable in cartilage from the constrained limb. The aggregation defect was rapidly reversible and aggregates were again normal size 2 weeks after removal of a cast that had been worn for 6 weeks.In normal articular cartilage most of the proteoglycans (PG) exist in large aggregates that are noncovalently linked to hyaluronic acid (HA) (1). In osteoarthritis (OA) an aggregation defect exists within the tissue, since a greater than normal proportion of the PGs is not aggregated and aggregates which are present tend to be smaller than normal (2-5).Aggregation defects similar to those of OA in

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Section: Discussionmentioning

confidence: 62%

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

Palmoski

Perricone

Brandt

1979

Arthritis & Rheumatism

283

131

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“…Entretanto, nos grupos 3 e 4, houve perda abrupta de metacromasia em áreas onde a cartilagem estava lesada. Esses resultados estão de acordo com Finsterbush e Friedman (1973) e Troyer (1975), que evidenciaram, em articulações imobilizadas, mudanças metabólicas com perda da coloração metacromática da matriz cartilaginosa previamente a qualquer mudança morfológica evidente à microscopia óptica. Figura 1.…”

Section: Resultsunclassified

Imobilização prolongada e remobilização da articulação fêmoro-tíbio-patelar de ratos: estudo clínico e microscópico

Carlo¹,

Galvão²,

Vilória³

et al. 2007

Arq. Bras. Med. Vet. Zootec.

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RESUMOTrinta e quatro ratos foram alocados em quatro grupos experimentais: sem imobilização (G1), com imobilização do joelho direito por 45 dias (G2), com imobilização e remobilização com atividade livre por cinco semanas (G3), imobilização e remobilização com atividade livre e natação por cinco semanas (G4). A imobilização interferiu negativamente na marcha e amplitude articular e o G4 apresentou melhor evolução na marcha nos cinco primeiros dias, em relação ao G3. Após esse período, a evolução foi similar. Os componentes do G2 apresentaram rigidez articular, não observada em G3 e G4. Histologicamente, a imobilização promoveu aumento da espessura da cápsula articular, evidenciada pela presença do tecido conjuntivo fibroso que substituiu o tecido adiposo no G2, mas em menor proporção em G3 e G4. A imobilização determinou perda de proteoglicanos da matriz cartilaginosa, aumento do número de condrócitos, dispostos de forma irregular, aumento da espessura da cartilagem calcificada, irregularidade da superfície articular, proliferação de tecido conjuntivo no espaço intra-articular e aumento da espessura do osso subcondral. O G3 apresentou maior número de alterações na cartilagem e osso subcondral, quando comparado com G4. A imobilização degenerou as células sinoviais, indicando diminuição da produção de fluido sinovial e do suprimento nutricional à cartilagem. Tanto a atividade livre quanto sua associação com a natação favoreceram o retorno das condições biomecânicas e da cápsula articular, anteriores à imobilização.Palavras-chave: rato, imobilização articular, remobilização articular, artrose ABSTRACT Thirty-four rats were randomly allocated into one of four experimental groups: without immobilization (G1), immobilization of the right knee joint for 45 days (G2), immobilization and remobilization with free activity for 5 weeks (G3), and immobilization and remobilization with free activity and swimming program for 5 weeks (G4). The immobilization was prejudicial to march and flexibility articular. Animals from G4 showed a better march evolution on the first five days as compared to those from G3. After that

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“…Not only immobilization, but also decreased weightbearing of a moving joint, has been shown to cause thinning of articular cartilage in guinea pigs (7) and to diminish the proteoglycan (PG) content of cartilage in dogs (89). The loss of metachromatic staining in the cartilage matrix of rabbit limbs after 2 days of immobilization indicates a rapid reduction in PGs (10). The smoothness of the articular surfaces is severely disturbed after 1 week in immobilized knee joints of rabbits (1 1).…”

mentioning

confidence: 99%

Weight bearing controls glycosaminoglycan concentration and articualr cartilage thickness in the knee joints of young beagle dogs

Kiviranta

Jurvelin

Tammi

et al. 1987

Arthritis & Rheumatism

204

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Casting of the right knee (stifle) joints of young beagle dogs for 11 weeks caused up to 48% reduction in the glycosaminoglycan (GAG) concentration of the uncalcified articular cartilage, as assessed by a new microspectrophotometric method. The GAGS were depleted mainly in the superficial zone of the cartilage. Although the thickness of the uncalcified cartilage was not decreased, the calcified cartilage under the tidemark was thinned by 6 2 5 % at the femoral condyles. The increased weight-bearing in the limb opposite the one in the splint caused uncalcified cartilage thickness to be augmented by 19% and GAG concentration by 25-35 % in the intermediate, deep, and calcified zones of the summits of the femoral condyles; the changes were smaller in other, less loaded parts of the joint. It is concluded that in young dogs, increased weight-bearing augments local proteoglycan content of the articular cartilage matrix, while unloading reduces it.

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The Effect of Short-Term Immobilization on the Rabbit Knee Joint Cartilage

Cited by 57 publications

References 0 publications

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

Imobilização prolongada e remobilização da articulação fêmoro-tíbio-patelar de ratos: estudo clínico e microscópico

Weight bearing controls glycosaminoglycan concentration and articualr cartilage thickness in the knee joints of young beagle dogs

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