The effect of sildenafil citrate on bladder outlet obstruction: a mouse model

Beamon, Charles R.; Mazar, Carla; Salkini, Mohamad; Phull, Hardeep; Comiter, Craig V.

doi:10.1111/j.1464-410x.2008.08324.x

Cited by 38 publications

(43 citation statements)

References 21 publications

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“…In addition, it has been observed that a chronic 4-week treatment with vardenafil significantly reduced the number of nonvoiding contractions in BOO rats, and may suggest a way to reduce irritative symptoms ( [34] further extended these results by showing that a 4-week treatment of BOO rats with vardenafil restored the contractile response in the bladder, implying that vardenafil had bladder protective effects. Finally, these data were confirmed by findings in mice, in which a 6-week oral treatment with sildenafil showed bladder protective effects [35]. Interestingly, in this study, sildenafil also decreased bladder muscular hypertrophy and bladder collagen levels, resulting in an increase in bladder capacity compared with placebo that had not been reported in other studies [35].…”

Section: Effects On the Bladdersupporting

confidence: 89%

“…Finally, these data were confirmed by findings in mice, in which a 6-week oral treatment with sildenafil showed bladder protective effects [35]. Interestingly, in this study, sildenafil also decreased bladder muscular hypertrophy and bladder collagen levels, resulting in an increase in bladder capacity compared with placebo that had not been reported in other studies [35]. The results in rats and mice with BOO strongly suggest that vardenafil and sildenafil reduce bladder-derived symptoms in obstructed animals.…”

Section: Effects On the Bladdersupporting

confidence: 88%

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Vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia

Porst

Sandner²,

Ulbrich³

2008

Curr prostate rep

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Section: Effects On the Bladdersupporting

confidence: 89%

Section: Effects On the Bladdersupporting

confidence: 88%

Vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia

Porst

Sandner²,

Ulbrich³

2008

Curr prostate rep

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“…PDE5-Is act mainly to relieve the dynamic and static obstruction of the prostate with a direct relaxation of the bladder [8]. Several in vitro studies have reported smooth muscle relaxation in the human bladder neck and prostate in the presence of PDE5-Is [24,25], and relaxation of the bladder neck and decreases in detrusor muscle overactivity have been detected in animal [26] and human studies [27]. Theoretically, the relaxation of the prostate and bladder neck after PDE5-I treatment could increase urinary flow; however, the concomitant relaxation of the detrusor muscle counteracts this effect, thereby preventing the observation of a final improvement in Q max [27].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Tadalafil Monotherapy for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Meta-Analysis

et al. 2013

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Objective: To evaluate the efficacy and safety of tadalafil monotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). Methods: A comprehensive search was done to identify randomized controlled trials comparing the efficacy and safety of tadalafil for LUTS/BPH with placebos. Meta-analytical techniques were applied to evaluate the differences in the study results. Results: Eight studies were identified and analyzed. Compared with placebo, tadalafil was associated with significant improvements in the International Prostate Symptom Score (IPSS) (mean difference = -2.19, p < 0.00001) and the International Index of Erectile Function (IIEF) score (mean difference = +4.66, p < 0.00001), despite the concomitant presence of erectile dysfunction. Significant differences were also observed in the IPSS irritative and obstructive subscores, IPSS quality of life index and BPH impact index. After pooling four doses (2.5, 5, 10 and 20 mg), tadalafil failed to produce a significant outcome in maximal urinary flow rate (Q_max) (mean difference = +0.26 ml/s, p = 0.14), but 5 mg of tadalafil significantly improved Q_max (mean difference = +0.63 ml/s, p = 0.04). No significant difference was detected in the incidence of serious adverse events (risk ratio = 1.00, p = 1.00) after tadalafil treatment. Conclusions: Tadalafil showed good efficacy and safety for improving LUTS and erectile dysfunction in men with BPH, and 5 mg of tadalafil significantly improved Q_max.

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“…There are several studies that have attempted to minimize histological damage caused by obstruction. In a study done by Beamon et al 27, sildenafil administered to rats with PBOO for six weeks prevented an increase in detrusor activity, voiding pressure, detrusor muscle hypertrophy and collagen deposition. Similarly, long-term and high-dose vardenafil administration to PBOO rats significantly increased bladder contraction, and thus it has been reported to have a protective effect on the bladder28.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of the effects of omega-3 & interferon alpha-2b administration on partial bladder outlet obstruction in a rat model

Fırat¹,

Uluocak

Erdemır

et al. 2016

Indian Journal of Medical Research

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Background & objectives: In bladder outlet obstruction-induced rat models, the transforming growth factor-beta (TGF-β) and collagen ratios have been shown to be increased. Increased TGF-β leads to fibrosis. In this study, the effect of omega-3 and interferon alpha-2b (IFN α-2b) was investigated on oxidative stress, inflammation and fibrosis in bladder structure in a partial bladder outlet obstruction (PBOO) rat model. Methods: A total of 35 male Wistar albino rats, weighing 300-350 g, were used in the study. The rats were randomly divided into five groups. At the end of the experimental period, bladders were harvested from all the rats, and pathological analysis of the rat bladder tissues was performed. In addition, investigations were carried out with enzymatic and non-enzymatic antioxidant systems to study the antioxidant properties of omega-3 fatty acid and IFN alpha-2b. Results: Increased bladder weight in the PBOO group, in comparison to the control group, was decreased by the administration of omega-3 and IFN α-2b (P=0.002). Significantly higher superoxide dismutase (SOD) levels were detected in group 2 in comparison to the control group. It was also detected that serum SOD, glutathione peroxidase and nitric oxide (NO) levels were significantly higher in group 2 when compared to the control group (P<0.05). In the pathologic evaluation, group 2 showed significantly increased inflammation and fibrosis compared to the control group. Omega-3 treatment significantly decreased inflammation. It was shown that IFN α-2b application partially decreased inflammation. Interpretation & conclusions: The results of the present study showed that in addition to the standard primary approaches to prevent the damage to the upper urinary tract secondary to PBOO, omega-3 fatty acid and IFN α-2b could be beneficial as adjunct treatment in clinical practice. However, this needs to be further investigated with prospective, randomized clinical trials with larger sample sizes.

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The effect of sildenafil citrate on bladder outlet obstruction: a mouse model

Cited by 38 publications

References 21 publications

Vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia

Vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia

Efficacy and Safety of Tadalafil Monotherapy for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Meta-Analysis

Evaluation of the effects of omega-3 & interferon alpha-2b administration on partial bladder outlet obstruction in a rat model

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