The Effect of Sildenafil on Respiratory Weaning of Patients with Chronic Obstructive Pulmonary Diseases Admitted to Intensive Care Unit

Rafiei, M R; Aghadavoudi, Omid; Hojjat, Mehrab

doi:10.5455/medarh.2012.66.104-106

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…Our results showed significant improvements in both FEV1 and FEV1/FVC values. One indirect contribution to our results has come from the study by Rafiei et al, 39 The authors found that Sildenafil facilitated the weaning of COPD patients from the ventilator through improvements in ventilator parameters. 39 Natriuretic peptides are biological hormones that are released from the heart in response to increased wall stress.…”

Section: Discussionmentioning

confidence: 97%

“…One indirect contribution to our results has come from the study by Rafiei et al, 39 The authors found that Sildenafil facilitated the weaning of COPD patients from the ventilator through improvements in ventilator parameters. 39 Natriuretic peptides are biological hormones that are released from the heart in response to increased wall stress. BNP and its derivative NT-proBNP are well-established markers of myocardial function and their measurements are recommended in the diagnosis and management of heart failure.…”

Section: Discussionmentioning

confidence: 97%

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Effects of Sildenafil on spirometric pulmonary function parameters, pulmonary artery systolic pressure and BNP levels in patients with chronic obstructive pulmonary disease and erectile dysfunction

Hakan

Demirtunç²

2021

IJIRM

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We aimed to investigate the effects of Sildenafil on pulmonary artery systolic pressure (PASP) as well as forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) and serum brain-type natriuretic peptide (BNP) levels in stable chronic obstructive pulmonary disease (COPD) patients with erectile dysfunction (ED). This was a prospective non-controlled interventional study that recruited COPD patients with ED between the ages of 49 and 79. International Index of Erectile Dysfunction Form (IIEF-5) was used for the evaluation of ED. Patients who had pulmonary artery systolic pressure >50 mmHg were included in the study. Single-dose Sildenafil 100 mg was administered orally to the patients. Before and after the drug ingestion, spirometry and echocardiographic measurements were performed, and serum BNP levels were measured as well. Forty-five male COPD patients with ED were included. Both percent predicted, and absolute FEV1 values increased significantly after the Sildenafil administration compared with baseline values (p<0.01). Similarly, the FEV1/FVC ratio also increased significantly with the Sildenafil administration compared to baseline values (p<0.01). Pulmonary artery systolic pressure significantly decreased from its baseline value with Sildenafil administration (p<0.01). Serum BNP values significantly reduced with Sildenafil administration compared to the pre-treatment values (p<0.01). This is the first study conducted in COPD patients with erectile dysfunction who had also pulmonary hypertension. The single-dose Sildenafil administration reduced PASP and serum BNP levels significantly. For the first time in the literature, we showed that the spirometric pulmonary function tests, namely FEV1 and FEV1/FVC ratio, improved significantly with the Sildenafil administration.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Effects of Sildenafil on spirometric pulmonary function parameters, pulmonary artery systolic pressure and BNP levels in patients with chronic obstructive pulmonary disease and erectile dysfunction

Hakan

Demirtunç²

2021

IJIRM

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“…Some clinical reports pointed out beneficial effects of sildenafil therapy on severe COPD with PH patients (Chapman et al 2009;Blanco et al 2010Blanco et al , 2013Lederer et al 2012;Rafiei et al 2012;Sharif-Kashani et al 2014;Chen et al 2015;Shrestha et al 2017;Vitulo et al 2017). For further exploration of the mechanism leading to the above results, a severe COPD with PH animal model is essential.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats

Ren

Shen

et al. 2020

Pharmaceutical Biology

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Context: Clinical reports showed sildenafil beneficial therapy on severe chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) patients. Objective: The study investigated therapeutic effects of silenafil on pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats. Materials and methods: Female Sprague-Dawley rats (200-250 g) were divided into control group (no exposure, n ¼ 10) and exposure group (n ¼ 50) suffered from cigarette smoke exposure and Klebsiella pneumonia inhalation for 8 weeks. Then rats were orally given normal saline (control group or model group), 2.0, 3.0, or 4.5 mg/kg sildenafil for 4 weeks, respectively. Pulmonary pressure, RVHI and morphological analysis of pulmonary vascular remodeling, respiratory functions assay, morphological analysis of pulmonary alveoli, and expression of PCNA and caspase-3 of epithelial cells in bronchioles wall were examined. Results: Compared to model rats, 2.0, 3.0, and 4.5 mg/kg sildenafil increased VT by -0.6 to 9.58%, PEF by 3.12 to 6.49%, EF50 by 0.81 to 6.50%, decreased mPAP by 4.43 to 25.58%, RVHI by 6.54 to 26.41%, showing a dose-dependent improvement. Furthermore, 4.5 mg/kg sildenafil significantly increased MAN by 39.70%, LA/CSA by 37.07%, decreased muscular pulmonary arteries by 48.00%, WT by 12.83%, MT by 22.89%, caspase-3 expression by 17.71%, and showed improvement on abnormality in lung interstitial and bronchioles by microscopy. Discussion and conclusion: Our results demonstrated that sildenafil decreased pathological changes in alveoli, bronchioles, interstitial tissue, and arterioles of rats with COPD and PH.

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Non-Sexual Implications of Phosphodiesterase Type 5 Inhibitors

Mostafa

2017

Sexual Medicine Reviews

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The Effect of Sildenafil on Respiratory Weaning of Patients with Chronic Obstructive Pulmonary Diseases Admitted to Intensive Care Unit

Cited by 4 publications

References 21 publications

Effects of Sildenafil on spirometric pulmonary function parameters, pulmonary artery systolic pressure and BNP levels in patients with chronic obstructive pulmonary disease and erectile dysfunction

Effects of Sildenafil on spirometric pulmonary function parameters, pulmonary artery systolic pressure and BNP levels in patients with chronic obstructive pulmonary disease and erectile dysfunction

Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats

Non-Sexual Implications of Phosphodiesterase Type 5 Inhibitors

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