The effect of silymarin (<i>Silybum marianum</i>) on human skin fibroblasts in an<i>in vitro</i>wound healing model

Sharifi, Roya; Pasalar, Parvin; Kamalinejad, Mohammad; Dehpour, Ahmad Reza; Tavangar, Seyed Mohammad; Paknejad, Maliheh; Natanzi, Mahboobeh Mehrabani; Nourbakhsh, Mitra; Ashtiani, Hamid Reza Ahmadi; Akbari, M; Rastegar, Hossein

doi:10.3109/13880209.2012.721789

Cited by 35 publications

(20 citation statements)

References 38 publications

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“…It may suggest that the protection is not due to the direct interaction of silymarin and H 2 O 2 . Silymarin is more likely to alter the cell membrane (Sharifi et al, 2013). Taking into consideration these data, the mechanism of cytotoxicity of ethanolic extracts from Oleaceae plants in UVA-irradiated fibroblasts seems to be more complex and there is a necessity for further investigation.…”

Section: Resultsmentioning

confidence: 99%

“…Human fibroblasts might be involved in the process of photoaging via biochemical and morphological changes induced by oxidative agents, such as UV-radiation. It is considered that they play an important role in the skin protection process by initiating the proliferative phase of repair, as well as secreting collagens and glycosaminoglycans (Sharifi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

Czerwińska

Duszak

Parzonko

et al. 2016

Acta Biologica Cracoviensia S. Botanica

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Plants belonging to the family Oleaceae have been traditionally used in treatment of various inflammatory skin disorders. One of the most well-known species is Olea europaea L. (olive), cultivated in the Mediterranean countries. Another species is Ligustrum vulgare L. (common privet), occurring particularly in Northern Europe and Asia. The aim of the study was a comparison of the composition of aqueous and ethanolic extracts from leaves of O. europaea and L. vulgare (HPLC-DAD-MS), and determination of the total content of phenolics and flavonoids, as well as the content of the major compound, oleuropein. Secondly, we aimed to study the protective effect of extracts on reactive oxygen species (ROS) production by human fibroblast cells (NHDF), cell viability (MTT assay), and apoptosis rate (Annexin V/propidium iodide staining) after UVA-irradiation. The phytochemical analysis allowed us to identify compounds belonging to the groups of flavonoids, phenylpropanoids and secoiridoids in the extracts. The compounds from the group of lignans (olivil) were identified as being unique to O. europaea extracts. Echinacoside, ligustroflavone and ligustaloside A were identified in L. vulgare extracts in contrast to olive preparations. It was established that the aqueous and ethanolic extracts from leaves of both species, except the privet aqueous extract at a concentration of 5 μg/ml, did not show any significant inhibition of ROS production after UVA-irradiation in the model of NHDF cell line. The aqueous extracts of both species at concentrations of 5 and 25 μg/ml had a protective effect on the viability of UVA-treated cells in contrast to the ethanolic extract. In conclusion, no significant difference in the activity of olive and privet leaf extracts has been observed, which suggests that both plant materials' extracts, particularly aqueous ones, are effective herbal medicines and photoprotectors, which -to some extent -confirms the use of their preparations in skin disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

Czerwińska

Duszak

Parzonko

et al. 2016

Acta Biologica Cracoviensia S. Botanica

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“…Cytotoxic (Barboza et al 2009), analgesic (Rondina et al 2008), antioxidant, antifungal (Alonso and Desmarchelier 2005). Antioxidant, antimicrobial (Souza et al 2004), anti-inflammatory (Pérez-García et al 1996), antinociceptive, gastroprotective (Figueredo et al 2011), analgesic (Rondina et al 2008), vulnerary (Schmidt et al 2009 Antitumor (Cheung et al 2010), antiinflammatory (Sharifi et al 2013), immunomodulatory, antioxidant (Das and Mukherjee 2012), antiviral (Wagoner et al 2010), hypoglycemic (Zhan et al 2011), galactogogue (Di Pierro et al 2008), nephroprotective (Turgut et al 2008), hepatoprotective, hypocholesterolemic (Krecman et al 1998;Shaker et al 2010 Antidiabetic, stimulant, tonic, antitumor, digestive, stomachic, antidiarrheal, anticonstipation, prebiotic, hypocholesterolemic, antioxidant, anti-atherosclerotic, slimming, diuretic, antinephritic, immunostimulant, hypotensive, improving vision, fortifying bones and teeth (Calcium assimilation), skin antiaging, vulnerary. O: Edible (roots).…”

Section: Guaco Southern South America Hp [H254]mentioning

confidence: 99%

Medicinal and aromatic species of Asteraceae commercialized in the conurbation Buenos Aires-La Plata (Argentina)

Hurrell¹,

Puentes²

2013

Ethnobio Conserv

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The present contribution includes 50 species of Asteraceae whose products are marketed with therapeutic and aromatic purposes in the conurbation Buenos Aires-La Plata, the largest metropolitan area of Argentina. For each species, the scientific and vernacular names, types of products and samples are given. The plant products comprise fresh plants or parts thereof, herbal products, tinctures, and dietary supplements, among others. The uses assigned and the effects scientifically studied are indicated. Also, the ethnobotanical value of the diverse plant products and their commercial circulation are discussed. Circulating products and their uses were studied, both in the restricted context of immigrant segments (Bolivian and Chinese), and in the broader context of general commercial circuit (health food stores, named locally 'dietéticas'). Botanical knowledge of immigrants segments is considered linked to their traditions, and botanical knowledge of general commercial circuit is regarded nontraditional. Research conducted is framed within the urban ethnobotany context. Specially, it addresses some relevant theoretical and methodological topics within discipline: composition of botanical knowledge in urban pluricultural scenarios (linked to traditions, nontraditional), the embodiment of this knowledge in actions (such as selection of products to consume), and the dynamic of changes in urban botanical knowledge (dispersion of products and uses in the commercial circuit and media).

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“…This mechanism is used in an animal model of hepatic injury in order to test a compound's inhibitory effects on functional hepatic injury (4). In addition, silymarin, which has strong antioxidative function, can protect hepatic cells from free radicals and contribute to protein synthesis so as to speed up production of new hepatic cells and promote injured hepatic cell repair (5). Therefore, silymarin maintains the function of protecting hepatic cells from invasion of toxic substances, especially those from alcohol and environmental pollutants like pesticides and heavy metals; moreover, silymarin can inhibit lipoxygenase and peroxidase.…”

Section: Introductionmentioning

confidence: 97%

Insect tea extract attenuates CCl4-induced hepatic damage through its antioxidant capacities in ICR mice

Liao¹,

Zou

Wang

2016

Food Sci Biotechnol

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The Insect tea extract (ITE) contained many polyphenols, the aim of the present study was to determine the preventive effects of ITE on CCl-induced hepatic damage in mice. ITE treated mice could reduce hepatic injury compared to the control mice. The 200 mg/kg ITE increased TC, ALB, SOD, CAT, GSH-Px serum levels, and decreased ALT, AST, ALP, TG, BUN, NO, MDA levels compared to the control group. By histological observation, ITE reduced injury to hepatic cells, and these effects were close to that seen with the drug silymarin. The antioxidant related mRNA and protein expressions of Mn SOD, Gu/Zn SOD, CAT, and GSH-Px increased with ITE treatment in hepatic damage mice. ITE treated mice also showed higher IκB-α mRNA and protein expression, and lower NF-κB-p65, iNOS, COX-2 expressions than those of control mice. These results proved ITE has a prophylactic effect in protecting against hepatic injury through the antioxidant capacities.

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The effect of silymarin (Silybum marianum) on human skin fibroblasts in anin vitrowound healing model

Cited by 35 publications

References 38 publications

Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

Medicinal and aromatic species of Asteraceae commercialized in the conurbation Buenos Aires-La Plata (Argentina)

Insect tea extract attenuates CCl4-induced hepatic damage through its antioxidant capacities in ICR mice

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