2014
DOI: 10.1111/1755-5922.12057
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The Effect of Simvastatin–Ezetimibe Combination Therapy on Adipose Tissue Hormones and Systemic Inflammation in Patients with Isolated Hypercholesterolemia

Abstract: SUMMARYBackground: Pleiotropic effects of ezetimibe have only been investigated in a few studies. The aim of this article was to compare the effects of simvastatin and the combined treatment with simvastatin and ezetimibe on low-grade systemic inflammation and plasma levels of selected adipokines in patients with isolated hypercholesterolemia. Methods: The study included 69 patients with elevated cholesterol levels, who were allocated to one of the three groups treated for 12 weeks, respectively, with simvasta… Show more

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Cited by 41 publications
(53 citation statements)
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“…In the whole population of patients, the effect of ezetimibe and simvastatin/ezetimibe combination therapy on plasma adipokines and hsCRP correlated with its impact on HOMA-IR, while the effect of ezetimibe was stronger in insulin-resistant than in insulin-sensitive subjects [21,22,24]. Correlations between adipokines or hsCRP and insulin sensitivity in ezetimibe-treated patients were also observed in both younger and older patients, analysed in the present study, but they were weak.…”
Section: Discussionsupporting
confidence: 42%
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“…In the whole population of patients, the effect of ezetimibe and simvastatin/ezetimibe combination therapy on plasma adipokines and hsCRP correlated with its impact on HOMA-IR, while the effect of ezetimibe was stronger in insulin-resistant than in insulin-sensitive subjects [21,22,24]. Correlations between adipokines or hsCRP and insulin sensitivity in ezetimibe-treated patients were also observed in both younger and older patients, analysed in the present study, but they were weak.…”
Section: Discussionsupporting
confidence: 42%
“…The study was a retrospective analysis of the previous studies of our research team [20,22,24]. The study protocol was approved by the local ethical committee, and all patients participating in the original studies gave their written informed consent before the beginning of the study.…”
Section: Methodsmentioning
confidence: 99%
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“…The aim of our study was to compare the effects of 30-day treatment with two hypolipidaemic agents, atorvastatin and ezetimibe, administered alone or in combination, on plasma adipokine levels in men and women with isolated hypercholesterolaemia, participating in our previous studies [7][8][9]. The results of one study were not taken into consideration because of a longer period of treatment [10]. Leptin, adiponectin, visfatin, and TNF-a were chosen among different adipokines because they are major products of adipose tissue, playing a variety of roles in atherosclerotic plaque development and its clinical sequelae.…”
Section: Introductionmentioning
confidence: 99%