The effect of single aerobic exercise on the regulation of mitochondrial biogenesis in skeletal muscles of trained men: A time-course study

Popov, D. V.; Лысенко, Е. А.; Miller, T. F.; Bachinin, A. V.; Perfilov, Dmitriy V.; Виноградова, О. Л.

doi:10.1134/s0362119715030123

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…As shown in Figure 11 , intermittent exercise induces higher phosphorylation of AMPK and CaMKII compared to continuous exercise. One of the reasons may be insufficient time for a continuous trial, as 30 min of moderate-intensity exercise did not affect AMPKα1/2 Thr172 phosphorylation or induce PGC-1α expression in trained athletes [ 93 ]. As sedentary individuals take part in [ 92 ] (VO 2peak : 44 ± 6 mL/min/kg), other factors may prevail.…”

Section: Hypothesismentioning

confidence: 99%

“…Based on the fast drop of CaMKII phosphorylation and activity after the fast initial rise during exercise at the same intensity corresponding to 67 ± 2% of VO2peak [27], we speculate that suppressed AMPK activity after a continuous trial [92] is linked to suppressed CaMKII phosphorylation and its activity and to increased PP2A activity (trig- As shown in Figure 11, intermittent exercise induces higher phosphorylation of AMPK and CaMKII compared to continuous exercise. One of the reasons may be insufficient time for a continuous trial, as 30 min of moderate-intensity exercise did not affect AMPKα1/2 Thr172 phosphorylation or induce PGC-1α expression in trained athletes [93]. As sedentary individuals take part in [92] (VO 2peak : 44 ± 6 mL/min/kg), other factors may prevail.…”

Section: Generalized Schemementioning

confidence: 99%

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Numerous Trigger-like Interactions of Kinases/Protein Phosphatases in Human Skeletal Muscles Can Underlie Transient Processes in Activation of Signaling Pathways during Exercise

Vertyshev¹,

Akberdin

Kolpakov

2023

IJMS

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Optimizing physical training regimens to increase muscle aerobic capacity requires an understanding of the internal processes that occur during exercise that initiate subsequent adaptation. During exercise, muscle cells undergo a series of metabolic events that trigger downstream signaling pathways and induce the expression of many genes in working muscle fibers. There are a number of studies that show the dependence of changes in the activity of AMP-activated protein kinase (AMPK), one of the mediators of cellular signaling pathways, on the duration and intensity of single exercises. The activity of various AMPK isoforms can change in different directions, increasing for some isoforms and decreasing for others, depending on the intensity and duration of the load. This review summarizes research data on changes in the activity of AMPK, Ca2+/calmodulin-dependent protein kinase II (CaMKII), and other components of the signaling pathways in skeletal muscles during exercise. Based on these data, we hypothesize that the observed changes in AMPK activity may be largely related to metabolic and signaling transients rather than exercise intensity per se. Probably, the main events associated with these transients occur at the beginning of the exercise in a time window of about 1–10 min. We hypothesize that these transients may be partly due to putative trigger-like kinase/protein phosphatase interactions regulated by feedback loops. In addition, numerous dynamically changing factors, such as [Ca2+], metabolite concentration, and reactive oxygen and nitrogen species (RONS), can shift the switching thresholds and change the states of these triggers, thereby affecting the activity of kinases (in particular, AMPK and CaMKII) and phosphatases. The review considers the putative molecular mechanisms underlying trigger-like interactions. The proposed hypothesis allows for a reinterpretation of the experimental data available in the literature as well as the generation of ideas to optimize future training regimens.

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Section: Hypothesismentioning

confidence: 99%

Section: Generalized Schemementioning

confidence: 99%

Numerous Trigger-like Interactions of Kinases/Protein Phosphatases in Human Skeletal Muscles Can Underlie Transient Processes in Activation of Signaling Pathways during Exercise

Vertyshev¹,

Akberdin

Kolpakov

2023

IJMS

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“…Exercise can reduce the damage of skeletal muscle due to oxidative stress. Intermittent training may be a better exercise method from the perspective of improving mitochondrial function and preventing mitochondrial diseases [2]. Intermittent exercise training is also a time-saving exercise method.…”

Section: Introductionmentioning

confidence: 99%

Effects of Intermittent Exercise on Rat Skeletal Muscle Gene Cells and Related Factors

2020

IJPHPM

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Skeletal muscle is vital for humans and animals, and it is an important source of movement system. Intermittent exercise is a training method that can cause skeletal muscles to adapt quickly. Therefore, it is necessary to actively carry out research on the effect of intermittent exercise on skeletal muscle gene cells and related factors in rats. The purpose of this article is to explore the effect of intermittent exercise on skeletal muscle gene cells of rats, and to analyze in detail the mechanism and related problems of intermittent exercise on skeletal muscle gene cells of rats by experimental methods. The effects and detailed processes of intermittent exercise on the proliferation, differentiation and apoptosis of skeletal muscle gene cells were studied in depth, and the differences in the expression of related genes and some differences in their physiological processes were investigated and studied in detail. The results show that it is feasible to use intermittent exercise to promote the recovery and improvement of skeletal muscle gene cells, which can effectively prevent skeletal muscle damage. Moreover, exercise training has a certain relief and prevention effect on skeletal muscle aging injury, regulates the early skeletal muscle susceptibility to apoptosis, reduces the skeletal muscle injury rate of rats by 45%, and increases the skeletal muscle by 28% gene cell expression.

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Coordination of mitochondrial biogenesis by PGC-1α in human skeletal muscle: A re-evaluation

2018

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The effect of single aerobic exercise on the regulation of mitochondrial biogenesis in skeletal muscles of trained men: A time-course study

Cited by 8 publications

References 28 publications

Numerous Trigger-like Interactions of Kinases/Protein Phosphatases in Human Skeletal Muscles Can Underlie Transient Processes in Activation of Signaling Pathways during Exercise

Numerous Trigger-like Interactions of Kinases/Protein Phosphatases in Human Skeletal Muscles Can Underlie Transient Processes in Activation of Signaling Pathways during Exercise

Effects of Intermittent Exercise on Rat Skeletal Muscle Gene Cells and Related Factors

Coordination of mitochondrial biogenesis by PGC-1α in human skeletal muscle: A re-evaluation

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