The effect of size and aspect ratio of Fe-MIL-88B-NH2 metal-organic frameworks on their relaxivity and contrast enhancement properties in MRI: in vitro and in vivo studies

Dehghani, Sadegh; Alam, Nader Riahi; Shahriarian, Shahriar; Mortezazadeh, Tohid; Haghgoo, Soheila; Golmohamadpour, Azadeh; Majidi, Behnam

doi:10.1007/s11051-018-4376-2

Cited by 24 publications

(11 citation statements)

References 51 publications

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“…17 With development of nanotechnology, NPs especially noble metal NPs, have also been developed as a hopeful approach to improve RT technique efficacy due to their unique physical and chemical properties. Radio-sensitizers have provided novel and great tools for imaging, 18 , 19 diagnosing, 20 and treating cancer. 21 - 24 To date, several different NPs such as gold, iron, bismuth, titanium and carbon have been applied as probable tumor-selective radio-sensitizers.…”

Section: Introductionmentioning

confidence: 99%

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

et al. 2020

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In recent years, high atomic number nanoparticles (NPs) have emerged as promising radio-enhancer agents for cancer radiation therapy due to their unique properties. Multi-disciplinary studies have demonstrated the potential of NPs-based radio-sensitizers to improve cancer therapy and tumor control at cellular and molecular levels. However, studies have shown that the dose enhancement effect of the NPs depends on the beam energy, NPs type, NPs size, NPs concentration, cell lines, and NPs delivery system. It has been believed that radiation dose enhancement of NPs is due to the three main mechanisms, but the results of some simulation studies failed to comply well with the experimental findings. Thus, this study aimed to quantitatively evaluate the physical, chemical, and biological factors of the NPs. An organized search of PubMed/Medline, Embase, ProQuest, Scopus, Cochrane and Google Scholar was performed. In total, 77 articles were thoroughly reviewed and analyzed. The studies investigated 44 different cell lines through 70 in-vitro and 4 in-vivo studies. A total of 32 different types of single or core-shell NPs in different sizes and concentrations have been used in the studies.

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Section: Introductionmentioning

confidence: 99%

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

et al. 2020

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“…However, as a result of MRI low sensitivity, acquired images could suffer from insufficient contrast, hence limitation of clinical applications. To enhance contrast as well as diagnostic accuracy, several exogenous contrast agents (CAs) have been developed and applied in MRI [12]. Compared to conventional contrast agents, nanoparticles offer several merits that one of them is loadability, in which the concentration of the imaging agent can be adjusted to suit the particular nanoparticle in the synthesis process.…”

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confidence: 99%

Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

et al. 2020

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Background: Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas. Objective: In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd2O3) coated polycyclodextrin (PCD) and modified with glucose (Gd2O3@PCD-Glu) for the targeting of overexpressed glucose receptors. Material and Methods: In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd2O3@PCD-Glu NPs. Furthermore, the capacity of transporting Gd2O3@PCD-Glu NPs to tumor cells was evaluated. Results: It was found that the acquired MRI T1 signal intensity of MDA-MB-231 cells that were treated with the Gd2O3@PCD-Glu NPs increased significantly. Based on the results obtained, Gd2O3@PCD-Glu NPs can be applied in targeting Glut1-overexpressing tumor cells in vivo, as well as an MRI-targeted tumor agent to enhance tumor diagnosis. Conclusion: Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity.

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“…The infrared (IR) spectra of GO/NH 2 ‐MIL‐88B show some characteristic bands appearing around 3400 and 3300 cm −1 , which signify the presence of symmetric and asymmetric stretching absorptions of primary amine groups (NH 2 ): around 1580 cm −1 for carboxylate group (COO − ) and around 500 cm −1 for O–Fe–O vibrations. [ 20,38 ] The GO material in the GO/NH 2 ‐MIL‐88B remains undetectable through FTIR spectroscopy. The above limitations on the detection of GO material may be attributed to the low quantity of GO in the GO/NH 2 ‐MIL‐88B composite.…”

Section: Resultsmentioning

confidence: 99%

Graphene oxide incorporated amino‐functionalized iron terephthalate composite as a heterogeneous Fenton‐like catalyst

Liew

Nguang

Minggu

et al. 2021

J Chinese Chemical Soc

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Amino-functionalized iron terephthalate metal-organic framework (NH 2 -MIL-88B) has been studied for its adsorption and catalytic properties due to its high surface area and unique topological architecture. Functionality of the material can be improved through surface modification to increase active sites for the targeted applications. In this study, graphene oxide (GO) was incorporated to the NH 2 -MIL-88B material to obtain composite with improved adsorption and catalytic properties. The results showed that GO/NH 2 -MIL-88B in dark (as GO/NH 2 -MIL-88B/Dark system) was capable to adsorb 28.1% of methylene blue (MB) in water, which is about twice the adsorption of MB by the NH 2 -MIL-88B material in dark (as NH 2 -MIL-88B/Dark system). Furthermore, with the presence of hydrogen peroxide (H 2 O 2 ), the GO/NH 2 -MIL-88B composite in dark condition (as GO/NH 2 -MIL-88B/H 2 O 2 /Dark) and the GO/NH 2 -MIL-88B composite under ultraviolet-A (UV-A) irradiation (as GO/NH 2 -MIL-88B/

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The effect of size and aspect ratio of Fe-MIL-88B-NH2 metal-organic frameworks on their relaxivity and contrast enhancement properties in MRI: in vitro and in vivo studies

Cited by 24 publications

References 51 publications

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

Graphene oxide incorporated amino‐functionalized iron terephthalate composite as a heterogeneous Fenton‐like catalyst

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