The effect of small bowel bypass on diabetes mellitus

Fielding, J. W. L.; Baddeley, R. M.

doi:10.1002/bjs.1800650109

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Weight loss consequent on decreased food intake has been considered the only factor responsible for the improvement of glucose tolerance in obese diabetic patients after in testinal bypass [4,10,29]; however, in our study the DBR gained weight and at the same time maintained improved glucose metabo lism during the whole of the 3-month follow up period.…”

Section: Discussioncontrasting

confidence: 43%

“…Several reports put forward the possibility of severe complications with JIB, like diarrhea, electrolyte imbalance and he patic failure [13,27], In spite of this many surgeons after long-term experience with JIB affirm that bypass operations can give excel lent results [6,16]. Besides a severe reduction in weight, JIB has a beneficial effect upon the control of diabetes in obese diabetic patients restoring a normal glucose tolerance [1,10,29].…”

Section: Introductionmentioning

confidence: 99%

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Observations on the Metabolic Effects of Partial Jejunoileal Bypass in Streptozotocin-Treated Rats

Morsiani

Carpanelli

1985

Eur Surg Res

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A 50% small bowel bypass was performed in diabetic rats (streptozotocin-treated) and in normal rats. Normal rats and diabetic rats were used as controls. Values of fasting blood glucose and oral glucose tolerance test showed a normalization and the disappearance of glycosuria, polyuria, polydipsia and hyperphagia in diabetic rats after surgery. Mean loss of weight 3 months after surgery was 9.1 % in normal bypassed rats and 60.5% in the diabetic controls. After an initial postoperative weigth loss of 33.4%, the diabetic bypassed rats gained subsequently their previous weight plus an increase of 7.2%. Improvement in carbohydrate metabolism appears to be independent of loss of weight and decrease in food intake in lean diabetic rats. Amelioration of diabetes after jejunoileal bypass is the result of several metabolic consequences, particularly the malabsorption of carbohydrates, fats and amino acids.

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Section: Discussioncontrasting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Observations on the Metabolic Effects of Partial Jejunoileal Bypass in Streptozotocin-Treated Rats

Morsiani

Carpanelli

1985

Eur Surg Res

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“…. patients, 4 showed miscellaneous abnormalities of much less marked severity and one retained a florid diabetic type of curve (Fielding and Baddeley, 1978). None of the patients required hypoglycaemic therapy.…”

Section: Beneficial Effectsmentioning

confidence: 99%

The management of gross refractory obesity by jejuno-ileal bypass

Baddeley

1979

Journal of British Surgery

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Jejuno-ileal bypass has been performed in 226 massively obese patients, 190 of whom have been followed for a minimum of 1 year. End-to-side and end-to-end anastomoses were compared and no difference in the weight reduction achieved by either technique was seen throughout the 5-year follow-up. There was no significant difference in weight reduction achieved between groups of patients in which the jejunal length varied from 10 to 35 cm and the ileal length from 35 to 10 cm. The weight reduction achieved in the entire series averaged 36-7 +/- 9-4 per cent at 2 years, after which no further loss occurred. Good psychological benefits were recorded. Remission of diabetes occurred in 12 of 13 patients and marked long term lowering of serum lipids was seen. Side effects included fluid and electrolyte disturbances and fatty changes in the liver during the first year, improving thereafter. Early cirrhosis of the liver occurred in 8-6 per cent. Other side effects included abdominal bloating, arthralgia and renal colic. The operative mortality was 0-9 per cent and the late mortality directly attributable to the jejuno-ileal bypass, 3-1 per cent. In 19 patients the bypass was discontinued because of severe side effects.

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Surgical techniques in the treatment of obesity

Baddeley¹

1979

The Treatment of Obesity

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The effect of small bowel bypass on diabetes mellitus

Cited by 5 publications

References 4 publications

Observations on the Metabolic Effects of Partial Jejunoileal Bypass in Streptozotocin-Treated Rats

Observations on the Metabolic Effects of Partial Jejunoileal Bypass in Streptozotocin-Treated Rats

The management of gross refractory obesity by jejuno-ileal bypass

Surgical techniques in the treatment of obesity

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