The Effect of Small Doses of Botulinum Toxin A on Neck-Shoulder Myofascial Pain Syndrome: A Double-Blind, Randomized, and Controlled Crossover Trial

Ojala, Tuula; Arokoski, Jari; Partanen, Juhani

doi:10.1097/01.ajp.0000151871.51406.c3

Cited by 102 publications

(77 citation statements)

References 27 publications

(35 reference statements)

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“…There are 12 studies in this category (Ferrante et al 2005;Guarda-Nardini et al 2008;Lew et al 2008;Kurtoglu et al 2008;Nixdorf et al 2002;Ojala et al 2006;Qerama et al 2006;Wheeler et al 2001b;Cheshire et al 1994 Table 1) 21 studies included in review 15 studies included in meta-anal ysis Gobel et al 2006;Wheeler et al 1998). A broad spectrum of patients were therefore represented in those trials with differences in affected anatomical sites, trigger points, previous exposure to conservative therapies, and presenting pain.…”

Section: Myofascial Pain Syndromementioning

confidence: 99%

The efficacy of botulinum toxin type A in managing chronic musculoskeletal pain: a systematic review and meta analysis

et al. 2010

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In our meta-analysis, BoNTA had a small to moderate analgesic effect in chronic musculoskeletal pain conditions. It was particularly effective in plantar fasciitis, tennis elbow, and back pain, but not in whiplash or shoulder pain patients. However, more evidence is required before definitive conclusions can be drawn. On the other hand, there is convincing evidence that BoNTA lacks strong analgesic effects in patients with myofascial pain syndrome. A general dose-dependent and temporal response with BoNTA injections was also observed.

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Section: Myofascial Pain Syndromementioning

confidence: 99%

The efficacy of botulinum toxin type A in managing chronic musculoskeletal pain: a systematic review and meta analysis

et al. 2010

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“…Botulinum toxin A injection (BTA) has been utilized in treatment for MTrPs [35][36][37][38]. However, it is rare clinically indicated, as it may be associated with possible local and systemic side effects such as muscle weakness and serious respiratory compromise [38,39].…”

Section: Botulinum Toxin a Injectionmentioning

confidence: 99%

The Use of Photomedicine in Musculoskeletal Pain

Al-Shenqiti¹

2017

Photomedicine - Advances in Clinical Practice

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Musculoskeletal pain is a major cause of disability. Myofascial trigger points (MTrPs) in particular are a common source of pain in a substantial number of patients presenting at a pain clinic. Many different invasive and non-invasive forms have been advocated to the treatment of MTrPs. However, favourable outcome rates are inconsistent and some of these treatment forms described are often painful and have potentially dangerous side effects. Photomedicine including the coherent light sources (lasers) and more recently, non-coherent light sources have been reported to be beneficial in soft tissue lesions including MTrPs. Their beneficial therapeutic effects can be obtained without undesired effects. The main intentions of this chapter are to bring the attention of the doctors and physical therapists to the scientific approach of photomedicine, in particular laser therapy for the relief of pain arising from MTrPs, and to demonstrate how this type of therapy can be utilized in a rational manner for the relief of musculoskeletal pain. In addition, it has been found necessary to include or to start with an overview of the recently recognized diagnostic and therapeutic importance of MTrPs. Attention will therefore first be drawn mainly to incidence, types, aetiology, clinical diagnostic criteria and conventional forms of MTrPs.

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“…In another study (double-blind, crossover), Ojala et al ( 2006 ) assessed the efficacy of onaA in 31 patients with MFPS. Patients had two injections, 4 weeks apart.…”

Section: Double-blind Placebo-controlled Studiesmentioning

confidence: 99%

“…The study of Ojala et al ( 2006 ) used two injections, 4 weeks apart. Since the effect of BoNTs often lasts 3 months, assessment of response to the second injection would be invalid.…”

Section: Commentmentioning

confidence: 99%

Botulinum Toxin Treatment of Myofascial Pain Syndrome and Fibromyalgia

Jabbari

2015

Botulinum Toxin Treatment of Pain Disorders

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Myofascial pain is one of the most common forms of human pain characterized by spontaneous and pressure-induced pain in muscle trigger points. Treatment of myofascial pain syndrome is partially successful with conventional analgesics, but a large number of patients remain unsatisfi ed.Botulinum neurotoxins (BoNTs) can relieve myofascial pain by blocking the release of acetylcholine and pain mediators (substance P, glutamate, calcitonin gene-related peptide) from presynaptic vesicles. Ten double-blind, placebocontrolled studies have been published in this area; some of these strongly support the palliative role of BoNTs in myofascial pain syndrome. Using onaA and abobotulinumtoxinA, the successful studies emphasize the importance of a fl exible rather than a fi xed pattern of injection and injection of more than fi ve trigger points in moderate or severe cases. Although the literature remains controversial, there is hope that future studies taking advantage of our current knowledge derived from positive studies can provide further support for the role of BoNT in management of myofascial pain syndrome.Fibromyalgia is a systemic disease characterized by diffuse muscle pain, fatigue, headaches, mood disorders, sleep disturbance, bowel disorders, and endocrine dysfunction. Lack of controlled data prohibits the use botulinum toxins for treatment of fi bromyalgia. Keywords

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The Effect of Small Doses of Botulinum Toxin A on Neck-Shoulder Myofascial Pain Syndrome: A Double-Blind, Randomized, and Controlled Crossover Trial

Abstract: Our study shows that there was no difference between the effect of small doses of botulinum toxin A and those of physiological saline in the treatment of myofascial pain syndrome.

Cited by 102 publications

References 27 publications

The efficacy of botulinum toxin type A in managing chronic musculoskeletal pain: a systematic review and meta analysis

The efficacy of botulinum toxin type A in managing chronic musculoskeletal pain: a systematic review and meta analysis

The Use of Photomedicine in Musculoskeletal Pain

Botulinum Toxin Treatment of Myofascial Pain Syndrome and Fibromyalgia

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