The Effect of Smoke Inhalation on Pulmonary Surfactant

Nieman, Gary F.; Clark, William R.; Wax, Stennis D.; Webb, Stanley

doi:10.1097/00000658-198002000-00008

Cited by 84 publications

(33 citation statements)

References 33 publications

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“…Lower surfactant levels were also reported in dogs who were exposed to smoke from burning wood or kerosene. (351).…”

Section: Other Factors Which Influence Surfactant Production In the Fmentioning

confidence: 99%

Lung surfactant.

Rooney¹

1984

Environ Health Perspect

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Aspects of pulmonary surfactant are reviewed from a biochemical perspective. The major emphasis is on the lipid components of surfactant. Topics reviewed include surfactant composition, cellular and subcellular sites as well as pathways of biosynthesis of phosphatidylcholine, disaturated phosphatidylcholine and phosphatidylglycerol. The surfactant system in the developing fetus and neonate is considered in terms of phospholipid content and composition, rates of precursor incorporation, activities of individual enzymes of phospholipid synthesis and glycogen content and metabolism. The influence of the following hormones and other factors on lung maturation and surfactant production is discussed: glucocorticoids, thyroid hormone, estrogen, prolactin, cyclic AMP, p-adrenergic and cholinergic agonists, prostaglandins and growth factors. The influence of maternal diabetes, fetal sex, stress and labor are also considered. Nonphysiologic and toxic agents which influence surfactant in the fetus, newborn and adult are reviewed.

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“…Lower surfactant levels were also reported in dogs who were exposed to smoke from burning wood or kerosene. (351).…”

Section: Other Factors Which Influence Surfactant Production In the Fmentioning

confidence: 99%

Lung surfactant.

Rooney¹

1984

Environ Health Perspect

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“…In addition to damage to the airways and pulmonary parenchyma, inhalation of toxic substances such as carbon monoxide or cyanide can produce detrimental systemic effects. [7,8] In recent decades, there has been a dramatic decline in the mortality of large burns. In contrast, despite considerable advances in our knowledge of the pathophysiology of inhalation injury, there are few specific therapeutic options, and patient care is mainly supportive.…”

Section: Methodsmentioning

confidence: 99%

Management of Inhalation Injury and Respiratory Complications in Burns Intensive Care Unit

Kabalak

Yastı²

2012

Ulus Travma Acil Cerrahi Derg

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AMAÇİnhalasyon yaralanması yüksek mortalite oranlarına sahiptir ve belirgin kalıcı pulmoner fonksiyon bozukluğu riski taşımaktadır. İnhalasyon yaralanması ve sonuçları, klinik yönetiminde ana rol oynayan solunum terapistlerine, hemşirelere ve doktorlara ciddi zorluklar oluşturur. Çalış-mamızda inhalasyon yaralanmalı hasta serimizdeki klinik tecrübelerimizi ve noninvazif mekanik ventilatör (NIMV) desteğinin rolünü bildirmeyi amaçladık. GEREÇ VE YÖNTEMAnkara Numune Eğitim ve Araştırma Hastanesi Yanık Yoğun Bakım Ünitesi'nde Mart 2009 -Mart 2011 yılları arasında yatarak tedavi alan hastalardan inhalasyon hasarı nedeniyle solunum desteğine ihtiyaç duyanlar çalışma-ya alındı. BULGULARBu hastaların 37'sinde inhalasyon yaralanması vardı, mortalite oranı %13,5 olarak bulundu, hastaların 16'sında zorunlu entübasyon uygulanırken (altı hastada ilk 6 saatte ve 10 hastada klinik seyir sürecinde) diğer hastalara sadece (%67,8) NIMV desteği uygulandı. SONUÇNIMV desteğinin uygun modlarda uygulanması, inhalasyon yaralanmalı olgularda invaziv yöntemlerin gerekliliği-ni azaltmaktadır. NIMV desteğinin inhalasyon yaralanmalı yanık hastalarında uygulanmasını önermekteyiz.Anahtar Sözcükler: İnhalasyon yaralanması; medikal tedavi; solunum yönetimi; ventilatör desteği. BACKGROUNDInhalation injury has high mortality and carries a significant risk of permanent pulmonary dysfunction. Inhalation injury and its consequences impose difficulties for the respiratory therapists, nurses and doctors who play a central role in its clinical management. In this study, we aimed to report our clinical experience and the role of non-invasive mechanic ventilatory (NIMV) support in a series of inhalation-injured patients. METHODSPatients hospitalized at Ankara Numune Training and Research Hospital's Burns Intensive Care Unit between March 2009 and March 2011 was reviewed, and patients with required respiratory support due to inhalation injury were included in the study. RESULTSAmong the patients, 37 had inhalation injury, and their mortality was 13.5%. Of the 37 patients, 16 had mandatory intubation (6 in the first 6 hours and 10 in the clinical course); however, others (67.8%) had only NIMV support. CONCLUSIONApplication of NIMV support with proper modes decreases the need for invasive procedures in inhalation-injured patients. Based on our results, we propose the application of NIMV support in inhalation-injured burn patients.

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“…Surfactant production is also reduced secondary to damage to the airway epithelium [17,18]. Prevention of pneumonia is difficult, but using HFPV and inhaled therapies, as previously discussed, may decrease the incidence of pneumonia.…”

Section: Inhalation Injurymentioning

confidence: 99%

Practical management of burns and inhalation injury

2016

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Burn injuries are often associated with profound physiologic derangements due to the nature of the underlying injuries and the overwhelming inflammatory response that ensues. In recent decades, a number of advancements have been made in the management of thermal burns. Inhalation injury frequently occurs in patients with thermal burns and can be a significant source of morbidity and mortality. Due to the intense inflammatory response that occurs after a burn injury, early aggressive volume resuscitation is necessary to minimize the risk of developing multiorgan dysfunction. Adequate sedation and analgesia, early enteral nutrition, physical rehabilitation, excision and grafting, and other supportive measures are also critically important to promoting healing and improving long-term outcomes. This review outlines a general approach to the management of patients with burn and inhalation injuries and highlights some of the recent advances in the care of these patients.

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The Effect of Smoke Inhalation on Pulmonary Surfactant

Cited by 84 publications

References 33 publications

Lung surfactant.

Lung surfactant.

Management of Inhalation Injury and Respiratory Complications in Burns Intensive Care Unit

Practical management of burns and inhalation injury

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