The effect of smoking on intestinal inflammation: What can be learned from animal models?

Verschuere, Stéphanie; Smet, Rita De; Allais, Liesbeth; Cuvelier, Claude

doi:10.1016/j.crohns.2011.09.006

Cited by 43 publications

(40 citation statements)

References 55 publications

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“…It also seems that smoking might determine disease location, with a higher prevalence of ileal disease and a lower prevalence of colonic involvement in smokers (16). This detrimental effect of smoking on CD might result from its strong immuno-modulatory capabilities (17)(18)(19). Higher prevalence of females in CD has been also recognized by some authors (20)(21)(22).…”

Section: Introductionmentioning

confidence: 93%

Different effect of smoking on genders in Crohn’s disease

Karczewski

Poniedziałek²,

Rzymski³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Smoking is a well-established environmental risk factor in Crohn's disease (CD). The study was aimed to investigate possible gender differences in the effect of smoking on the course of CD, with a special focus on selected immune parameters such as Th1/Th2/Th17 cytokines and regulatory T cells (Tregs). Materials and Methods: A group of 55 adults with CD was enrolled to the study. The analysis of clinical, demographic and immunological characteristics of patients was performed according to their smoking status and gender. Values were considered significant when p≤0.05. Results: Patients who smoked, particularly females, more frequently suffered from a moderate-to-severe form of the disease, requiring glucocorticoid and immunosuppressive therapies. Smokers, particularly females, were also hospitalized and underwent surgeries more frequently than non-smokers. Cytometric analysis showed higher levels of serum proinflammatory cytokines and lower levels of peripheral Tregs in female smokers and former smokers, comparing to males from these subgroups.Conclusion: Presented results demonstrate that in all investigated subgroups, particularly however among current smokers and former smokers, female patients seemed to be more affected by CD. Females developed more severe form of the disease and experienced the onset earlier than men. The imbalance between pro-and anti-inflammatory factors observed in CD patients was also more distinct in female smokers and former smokers, comparing to males, and could substantially contribute to the severity of the disease. Exposure to smoking seems to be one of the environmental factors contributing to the gender differences in CD.

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Section: Introductionmentioning

confidence: 93%

Different effect of smoking on genders in Crohn’s disease

Karczewski

Poniedziałek²,

Rzymski³

et al. 2015

Turk J Gastroenterol

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“…The route of administration was relevant on the final effect also when single CS components, such as nicotine, were administered to IBD mouse models or patients [47]. Thus, in a TNBS mouse model of CD, the detrimental effects of subcutaneous nicotine administration [77] contrasted with the dose-dependent bivalent effect of nicotine administered in the drinking water, that is, positive at low and negative at high concentrations [78,79].…”

Section: Inhalation Studies Investigating the Effect Of Cs In Rodent mentioning

confidence: 99%

“…Active human smoking is difficult to mimic under laboratory conditions, while classical in vitro approaches have translational limitations. Thus, several animal models have been used to assess the impact of CS, nicotine or non-nicotine CS constituents on intestinal pathophysiology [47]. Both genetic-and chemically induced IBD models have been used and effects of various treatment regimens on gut inflammation in these systems are summarised in Table 2.…”

Section: Inhalation Studies Investigating the Effect Of Cs In Rodent mentioning

confidence: 99%

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

Sasso¹,

Schlage²,

Phillips³

et al. 2018

Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy

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Inflammatory bowel diseases (IBDs) comprise primarily two disease manifestations, ulcerative colitis (UC) and Crohn's disease (CD), each with distinctive clinical and pathological features. Environmental and clinical factors strongly affect the development and clinical outcomes of IBDs. Among environmental factors, cigarette smoke (CS) is considered the most important risk factor for CD, while it attenuates the disease course of UC. Various animal models have been used to assess the impact of CS on intestinal pathophysiology. This chapter examines the suitability of animal inhalation/smoke exposure models for assessing the contrary effects of CS on UC and CD. It presents an updated literature review of IBD mouse models and a description of possible mechanisms relevant to relationships between IBD and smoking. In addition, it summarises various technical inhalation approaches, in the context of mouse disease models of IBD.

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“…Overall, the effect of smoke and its constituents on the small bowel seems deleterious, increasing susceptibility for inflammatory stimuli. Instead, in the colon, both pro-and anti-inflammatory effects are seen, possibly depending on genetic and environmental factors and cytokine environment [47]. Importantly, smoking also seems to have an effect on gut microbiome composition.…”

Section: Relations Between Smoking and Gut Microbiota And Their Relevmentioning

confidence: 99%

“…The best documented gastrointestinal effect of smoking, after carcinogenesis, is immunomodulation by nicotine and carbon monoxide [46,47]. Smoking increases the risk for and severity of Crohn's disease, but the opposite is seen with respect to ulcerative colitis [48].…”

Section: Relations Between Smoking and Gut Microbiota And Their Relevmentioning

confidence: 99%

Linking Smoking, Coffee, Urate, and Parkinson’s Disease – A Role for Gut Microbiota?

Scheperjans

Pekkonen

Kaakkola

et al. 2015

Journal of Parkinson’s Disease

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Abstract. While the etiology and pathogenesis of Parkinson's disease (PD) is still obscure, there is evidence for lifestyle factors influencing disease risk. Best established are the inverse associations with smoking and coffee consumption. In other contexts there is evidence that health effects of lifestyle factors may depend on gut microbiome composition. Considering the gastrointestinal involvement in PD, it was recently speculated, that the associations between smoking, coffee, and PD risk could be mediated by gut microbiota. Here we review such a possible mediatory role of gut microbiota taking into account recent findings on microbiome composition in PD and extending the scope also to urate.

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The effect of smoking on intestinal inflammation: What can be learned from animal models?

Cited by 43 publications

References 55 publications

Different effect of smoking on genders in Crohn’s disease

Different effect of smoking on genders in Crohn’s disease

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

Linking Smoking, Coffee, Urate, and Parkinson’s Disease – A Role for Gut Microbiota?

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