The effect of sodium repletion on growth and protein turnover in sodium-depleted rats

Wassner, Steven J.

doi:10.1007/bf01453690

Cited by 29 publications

(10 citation statements)

References 19 publications

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“…Metabolic acidosis is known to impair growth in rats, and is probably related to a negative sodium balance [37]. In our study, a strong positive relationship was observed between blood HCO3 levels during treatment and height SDS at the last observation, indicating a major role of metabolic acidosis in the development of growth failure in FS.…”

Section: Discussionsupporting

confidence: 54%

Body growth in primary de Toni-Debré-Fanconi syndrome

Haffner

Weinfurth

Seidel

et al. 1997

Pediatric Nephrology

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Body growth in nine children with primary de Toni-Debré-Fanconi syndrome was followed from birth to adolescence or adult life. At the time of diagnosis, corresponding to the start of treatment, the median age was 2.3 (range 0.4-13.9) years and height standard deviation score (SDS) was always decreased (median -3.5, range -6.8 to -2.1). Despite continuous electrolyte and bicarbonate supplementation only four patients showed a slight improvement in growth. At the time of the last observation at the age of 17.2 (4.5-20.1) years median height was -4.7 (-5.9 to -1.8) SDS. The median difference between height at last observation and target height was -4.5 SDS. Final height (n = 5) ranged between -1.8 and -5.5 (median -4.3) SDS. The pubertal growth spurt was absent in two children. Metabolic acidosis was identified as a significant growth-retarding factor. Mean serial blood bicarbonate levels and height SDS at the last observation were correlated (r = -0.87, P < 0.01). No correlation was observed between last height SDS and the degree of hypokalemia, hypophosphatemia, or hypercalciuria. In conclusion, patients with primary de Toni-Debré-Fanconi-syndrome present severe growth failure at the time of diagnosis which persists into adult life. Supportive therapy is frequently unable to prevent further loss of relative height.

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Section: Discussionsupporting

confidence: 54%

Body growth in primary de Toni-Debré-Fanconi syndrome

Haffner

Weinfurth

Seidel

et al. 1997

Pediatric Nephrology

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“…In addition, there is a large body of experimental evidence that sodium deficiency is harmful to the growth and development of newborn animals. [13][14][15][16][17][18][19][20] We therefore decided to recall the 46 previously studied sodium supplemented and unsupplemented infants, to perform detailed assessments of their physical, neurologi-cal, psychological, and educational status at 10-13 years of age and to correlate their performance with their sodium intake in the neonatal period.…”

mentioning

confidence: 99%

Effect of salt supplementation of newborn premature infants on neurodevelopmental outcome at 10-13 years of age

Al-Dahhan

Jannoun²,

Haycock

2002

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Background: The nutritional requirements of prematurely born infants are different from those of babies born at term. Inadequate or inappropriate dietary intake in the neonatal period may have long term adverse consequences on neurodevelopmental function. The late effect of neonatal sodium deficiency or repletion in the premature human infant on neurological development and function has not been examined, despite evidence in animals of a serious adverse effect of salt deprivation on growth of the central nervous system. Methods: Thirty seven of 46 children who had been born prematurely (gestational age of 33 weeks or less) and allocated to diets containing 1-1.5 mmol sodium/day (unsupplemented) or 4-5 mmol sodium/day (supplemented) from the 4th to the 14th postnatal day were recalled at the age of 10-13 years. Detailed studies of neurodevelopmental performance were made, including motor function and assessment of intelligence (IQ), memory and learning, language and executive skills, and behaviour. Sixteen of the children were found to have been in the supplemented group and 21 in the unsupplemented group. Results: Children who had been in the supplemented group performed better in all modalities tested than those from the unsupplemented group. The differences were statistically significant (analysis of variance) for motor function, performance IQ, the general memory index, and behaviour as assessed by the children's parents. The supplemented children outperformed the unsupplemented controls by 10% in all three components of the memory and learning tests (difference not significant but p < 0.1 for each) and in language function (p < 0.05 for object naming) and educational attainment (p < 0.05 for arithmetic age). Conclusions: Infants born at or before 33 weeks gestation require a higher sodium intake in the first two weeks of postnatal life than those born at or near term, and failure to provide such an intake (4-5 mmol/day) may predispose to poor neurodevelopmental outcome in the second decade of life.

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“…A negative sodium balance is a detrimental factor for growth (1)(2)(3)(4) and in immature animals it has been shown to inhibit DNA synthesis (5). The negative effect on growth persists even if the sodium intake is adequately compensated for at a later time in development (6). This implies that sodium is a permissive factor for optimal growth early in development.…”

mentioning

confidence: 99%