1970
DOI: 10.1172/jci106229
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The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow

Abstract: A B S T R A C T The influence of bile salts on the hepatic metabolism of sulfobromophthalein sodium (BSP) was studied in the perfused rat liver. During sodium taurocholate infusions, hepatic uptake of BSP from plasma was increased and appeared to be related to an enhanced transit of BSP from liver into bile. BSP-glutathione conjugation was not affected by the bile salt infusions, although bile salts inhibited the enzyme system in vitro.The major effect of bile salts was to increase the BSP transport maximum (T… Show more

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Cited by 75 publications
(23 citation statements)
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“…This group of investigators showed that rose bengal in the rabbit, like hypothermia in isolated rat liver (30), induced a decrease in bile flow by inhibiting the bile acidindependent fraction of bile flow. Hydrocortisone choleresis in the dog (33) and phenobarbital choleresis in the rat (34) are mediated by canalicular bile formation unrelated to osmotic effects or bile acid secretion.…”
Section: Methodsmentioning
confidence: 99%
“…This group of investigators showed that rose bengal in the rabbit, like hypothermia in isolated rat liver (30), induced a decrease in bile flow by inhibiting the bile acidindependent fraction of bile flow. Hydrocortisone choleresis in the dog (33) and phenobarbital choleresis in the rat (34) are mediated by canalicular bile formation unrelated to osmotic effects or bile acid secretion.…”
Section: Methodsmentioning
confidence: 99%
“…Physiological studies of bilirubin and other organic anion secretory rates in bile showed a strong correlation with bile acid secretory rates under stimulated conditions but not during fasting (3)(4)(5)(6)(7)(8). This observation led to studies that have concluded that a strong relationship exists between biliary mixed-lipid micelles and bilirubin in addition to a variety of other organic anions, although the precise nature of the putative micellar-organic anion interaction has remained unclear (9)(10)(11)(12)(13)(14)(15).…”
Section: Introductionmentioning
confidence: 99%
“…However, the regulatory mechanisms for the organic anion transport through the liver are not clearly understood. Metabolic biotrans formation in the liver cell (Shellhas et al 1965), and bile flow rate (Klaassen and Plaa 1968;Boyer et al 1970) are two factors believed to be most important in determining the biliary excretion rate.…”
mentioning
confidence: 99%
“…While some workers considered the increase in canalicular bile flow to be direct cause for the increased BSP Tm induced by bile salt infusion (Boyer et al 1970), bile salt excretion has been recently suggested as a unique determinant for BSP Tin (Erlinger and Dumont 1973;Gibson and Forker 1974).…”
mentioning
confidence: 99%