The Effect of Sodium Valproate on Sleep, Reaction Times, and Visual Evoked Potential in Normal Subjects

We analysed somatosensory evoked potentials (SEPs) in the patients with juvenile myoclonic epilepsy (JME) in order to find out if sodium valproate (VPA) affects SEP latencies and amplitudes.SEPs were studied in 23 patients with JME receiving VPA monotherapy, eight patients with JME not receiving VPA, and a control group consisting of 20 healthy subjects.The N20, P24, and N34 latencies bilaterally were significantly prolonged in the JME group receiving VPA as compared with the control group. In the untreated patients the P24, and N34 latencies bilaterally and the N20-P24 interpeak latency on the right, were significantly prolonged as compared with the control group. In addition, in the patient group without treatment, the N20-P24 amplitudes bilaterally and the P24-N34 amplitudes from left sided median nerve stimulation, were greater as compared with the control group.In the SEP latencies, no significant differences were observed between the patients treated and untreated with VPA. Regarding SEP amplitudes, in the untreated group, while the N20-P24 amplitudes from right sided median nerve stimulation were significantly enhanced, all the other amplitudes also showed increase, even insignificant, as compared with the patients treated by VPA.These findings suggest that the SEPs latencies are prolonged, and the amplitudes are enhanced in JME. The changes of the SEPs latency in JME could be due to abnormal synaptic transmission and not influenced by VPA. On the other hand, the increase of the amplitude tends to be lowered by VPA.

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“…Evoked potentials have been used in the assessment of the effects of AEDs on central neural conduction [4,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Sodium Valproate on Somatosensory Evoked Potentials in Juvenile Myoclonic Epilepsy

Erdem¹,

Yiğit²,

Çulcuoğlu³

et al. 2001

Upsala Journal of Medical Sciences

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“…Harding et al [13] found no effects of VPA on visual EPs. The only study on the effects of VPA on BAEP, by Mervaala et al [10], demonstrated only minor effects on BAEP, consisting of a prolongation of wave V. In our study the modifications induced by VPA were similar to the modifications induced by CBZ.…”

Section: Discussionmentioning

confidence: 99%

Effects of Long-Lasting Antiepileptic Therapy on Brainstem Auditory Evoked Potentials

Medaglini¹,

Filippi²,

Smirne³

et al. 1988

Neuropsychobiology

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The brainstem auditory evoked potentials of 84 epileptic patients in chronic monotherapy with carbamazepine (n = 36), phenobarbital (n = 19), Na-valproate (n = 20) or progabide (n = 9) were studied. The mean values of I–III and I–V interpeak latencies (IPLs) were respectively 2.16 ± 0.11 and 4.03 ± 0.17 in the control group, 2.31 ± 0.09 and 4.17 ± 0.16 in the valproic group, 2.30 ± 0.17 and 4.19 ± 0.20 in the carbamazepine group, 2.17 ±0.16 and 4.10 ± 0.18 in the phenobarbital group and 2.16 ± 0.11 and 4.12 ± 0.17 in the progabide group. The prolongation of I–III and I–V IPLs was statistically significant only for the valproic acid and carbamazepine groups. Neither duration of the epilepsy and treatment and frequency of seizures nor the serum drug levels were correlated with I–V IPL values.

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“…In general these agents tend to increase total sleep time, decrease number of awakenings, increase NREM stages 1 and 2, and decrease NREM stages 3 and 4 and REM (15). Furthermore, sleep architectural data on these agents' use in patients with epilepsy are scarce.…”

Section: Benzodiazepines (Bdzs)mentioning

confidence: 97%

Effects of Anticonvulsant Medication on EEG Sleep Architecture

Geurkink

Gidal

Hermann

2000

Epilepsy & Behavior

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The Effect of Sodium Valproate on Sleep, Reaction Times, and Visual Evoked Potential in Normal Subjects

Cited by 67 publications

References 5 publications

Effect of Sodium Valproate on Somatosensory Evoked Potentials in Juvenile Myoclonic Epilepsy

Effect of Sodium Valproate on Somatosensory Evoked Potentials in Juvenile Myoclonic Epilepsy

Effects of Long-Lasting Antiepileptic Therapy on Brainstem Auditory Evoked Potentials

Effects of Anticonvulsant Medication on EEG Sleep Architecture

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